Navigation Links
Brain size may depend upon how neural cells are cleaved

Howard Hughes Medical Institute researchers have discovered a novel way in which the brain size of developing mammals may be regulated. They have identified a signaling pathway that controls the orientation in which dividing neural progenitor cells are cleaved during development.

The way these cells are sliced during development is critical because at later stages of neurogenesis, vertical cleavage gives rise to two mature neurons that are incapable of further division, while horizontal cleavage yields one neuron and one progenitor cell that can continue to support brain growth.

The researchers speculate that this type of regulatory decision point may play a powerful role in determining the ultimate size of the mammalian brain. Inherited disorders that cause the brain to develop too small or too large may also influence this developmental pathway.

Howard Hughes Medical Institute investigator Li-Huei Tsai and postdoctoral fellow Kamon Sanada, both at Harvard Medical School, published their findings in the July 15, 2005, issue of the journal Cell.

The researchers drew on studies by other researchers that showed that the orientation of cleavage planes in dividing neural progenitor cells in the neocortex determines the fate of the resulting daughter cells. However, nothing was known about the molecular signaling mechanism that regulates the decision to cleave one way or another, said Tsai.

Studies in fruit flies and roundworms had hinted that major regulatory molecules called heterotrimeric G proteins play a role in orienting the mitotic spindles that govern the orientation of cell cleavage during cell division, or mitosis.

"Based on that knowledge, we knew that heterotrimeric G proteins were very good candidates as regulators of the plane of cell division in neural precursors," said Tsai.

"And this is a very important question, because how these cells divide ultimately determines the final number of cells that will
'"/>

Source:Howard Hughes Medical Institute


Page: 1 2 3

Related biology news :

1. Drug That Tags Decision-making Areas Of The Brain May Aid
2. NYU Study Reveals How Brains Immune System Fights Viral Encephalitis
3. Transport System Smuggles Medicines Into Brain
4. Bird Brains Show How Trial and Error May Contribute to Learning
5. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
6. Wiley announces publication of Databasing the Brain
7. Scientists Propose Sweeping Changes to Naming of Bird Neurosystems to Acknowledge Their True Brainpower
8. Brain-mapping technique aids understanding of sleep, wakefulness
9. Some Brain Cells Change Channels To Fine-tune The Message
10. Brain Scans Reveal How Gene May Boost Schizophrenia Risk
11. Brain-injury rehabilitation depends on acetylcholine circuitry
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Brain size may depend upon how neural cells are cleaved

(Date:4/14/2015)... NEW YORK , April 14, 2015 /PRNewswire/ ... Fast IDentity Online (FIDO ® ) Alliance tm ... standards-based specifications. FIDO members commit to share technology ... authentication methods that are interoperable, more secure and ... specifications enable biometric identity verification that protects sensitive ...
(Date:4/13/2015)... , April 13, 2015  higi, a leading ... ways to more fully engage with their communities around ... industry-leading, privacy protected and secure API.  ... enables the most accessible, affordable, and convenient vehicle to ... The API will allow ...
(Date:4/8/2015)... 2015  Infinisource, a leading provider of SaaS-based Human ... a leading supplier of biometric identification and security ... most advanced biometrically-enabled time clock, the companies announced ... is setting a bold, new standard for the ... small and mid-size employer. When connected to the ...
Breaking Biology News(10 mins):HYPR Corp. Joins the FIDO Alliance 2HYPR Corp. Joins the FIDO Alliance 3higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 2higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 3iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 3
... marine food chain, albatrosses accumulate toxic contaminants such as ... study has found dramatic differences in contaminant levels between ... areas of the North Pacific. Researchers also found that ... species over the past ten years. , The differences ...
... State University professor Dr. Patrick D. Lorch, have revealed ... Mormon crickets in western North America. , ... a fear of cannibalism, drives the mass migration of ... their seasonal migration, millions of Mormon crickets (relatives of ...
... of years ago, humans began scrubbing off and discarding ... white kernel beneath. Now, for the first time, scientists ... rice processing, called rice bran, significantly lowers blood pressure ... The team reports their findings in the March 8 ...
Cached Biology News:Vegetables inhibit growth of prostate cancer in mice with human tumors 2Vegetables inhibit growth of prostate cancer in mice with human tumors 3How nice, brown rice: Study shows rice bran lowers blood pressure in rats 2
(Date:5/20/2015)... 20, 2015  Select Medical Corporation ("Select") (NYSE: ... Commission granted early termination of the waiting period ... 1976, as amended, applicable to the acquisition of ... joint venture that Select has created with Welsh, ... previously announced, MJ Acquisition Corporation has signed a ...
(Date:5/20/2015)... (PRWEB) May 20, 2015 Agricultural firm ... anniversary of its acquisition of Tiger-Sul. Since the ... (Calgary Alberta, Canada) in May 2005, H.J. Baker has ... build it into a comprehensive portfolio of product offerings ... of H.J. Baker and the innovation of Tiger-Sul, transforming ...
(Date:5/20/2015)... DIEGO , May 20, 2015  Cypher ... announced a collaboration with Celgene Corporation to apply ... genomic biomarkers that associate with patient response to ... is intended to help accelerate patient access to ... efficiencies in clinical research and development and potentially ...
(Date:5/20/2015)... PARK, North Carolina , 20. ... führende Unternehmen für klinische Logistik (Clinical ... für das Geschäftsjahr 2014, das am ... eingereicht. Das Unternehmen hat die Marktentwicklung ... Logo - http://photos.prnewswire.com/prnh/20110930/NY78064LOGO ...
Breaking Biology Technology:Select Medical Corporation's Proposed Acquisition of Concentra Inc. through Joint Venture with Welsh Carson Receives Antitrust Clearance 2Agricultural Firm H.J. Baker & Bro., Inc., Celebrates 10 Years Since Acquisition Of Tiger-Sul 2Agricultural Firm H.J. Baker & Bro., Inc., Celebrates 10 Years Since Acquisition Of Tiger-Sul 3Cypher Genomics Collaborates with Celgene Corporation to Identify Novel Genomic Biomarkers 2Marken schließt Ergebnisse für das Geschäftsjahr 2014 ab 2
... LOUIS, June 5 /PRNewswire-FirstCall/ -- Express Scripts, ... at the William Blair Growth Stock Conference on Thursday, June 11, ... Chicago. , , This presentation will also be broadcast ... section of Express Scripts web site at http://www.express-scripts.com ...
... , For the second time in three years, ... recognized American Biotech Labs(R) as Utah,s top, company ... UT, June 4 /PRNewswire/ - American Biotech Labs, LLC (ABL), developer ... nano-catalytic SilverSol Technology(R), today announced that the company has won the ...
... (Nasdaq: ARNA ) announced today that the ... Sciences Conference on June 11, 2009 at 11:00 a.m. Eastern Time ... Hotel in New York City. Robert E. Hoffman, Arena,s Vice President, ... of the company, including its clinical development and research programs. , ...
Cached Biology Technology:Express Scripts to Present at William Blair Growth Stock Conference 2American Biotech Labs(R) Garners 2009 Utah Best of State Award 2American Biotech Labs(R) Garners 2009 Utah Best of State Award 3Arena Pharmaceuticals to Present at the 8th Annual Needham Life Sciences Conference 2Arena Pharmaceuticals to Present at the 8th Annual Needham Life Sciences Conference 3
... acid gel stain has bright fluorescence when bound ... it ideal for detecting dsDNA in gels using ... Green I nucleic acid stain has also ... assays and bandshift assays. A 500 µL unit ...
... techniques are defined by the author of ... This valuable hardcover guide includes hundreds of ... references. More than 300 pages detail the ... preparation from selection and design of ...
... proteomic service includes protein separation by ... the PDQuest software package from Bio-Rad ... spectrometry. In order to meet customers ... data analysis and format of the ...
... PerkinElmer kit provides reagents for immune complex ... and plasma samples using a combination of ... then neutralized and transferred to microplate wells ... mouse monoclonal antibody to HIV-1 p24. The ...
Biology Products: