Navigation Links
Brain regions do not communicate efficiently in adults with autism

A novel look at the brains of adults with autism has provided new evidence that various brain regions of people with the developmental disorder may not communicate with each other as efficiently as they do in other people.

Researchers from the University of Washington's Autism Center will report today at the annual meeting of the Society for Neuroscience on the first study that measures neural activity by using high-resolution electroencephalography (EEG) to examine connections in the cerebral cortex, the part of the brain that deals with higher cognitive processes.

Compared to normally developing individuals, the scientists found patterns of abnormal connectivity between brain regions in people with autism. These abnormalities showed both over and under connectivity between neurons in different parts of the cortex, according to Michael Murias, a postdoctoral researcher who headed the study.

"Our findings indicate adults with autism show differences in coordinated neural activity," said Murias, "which implies poor internal communication between the parts of the brain."

The UW researchers analyzed EEGs from 36 adults, ranging in age from 19 to 38. Half the adults had autism and all had IQs of at least 80. The EEGs, which measure the activity of hundreds of millions of brain cells, were collected with an array of 124 electrodes while the people were seated and relaxed with their eyes closed for two minutes.

The researchers found patterns of higher than normal neural connectivity in the left hemisphere, particularly in the temporal lobe of the persons with autism within two different frequencies of brain waves, the delta and theta bands. This part of the brain is associated with language, which is impaired in many people with autism.

A global pattern of decreased neural connectivity between the frontal lobes and the rest of autistic brain showed up on the alpha wave band. These findings support s everal other studies using functional magnetic resonance imaging and positron emission tomography, both of which gauge brain activity by measuring blood flow. Post-mortem studies also suggest impairments in communication at the level of individual brain cells.

This over and under abundance of neural connections suggests inefficient and inconsistent communication inside the brains of people with autism and may explain some of the deficits shown by people who have the disorder.

The research has practical applications. Murias believes the abnormal patterns of brain activity are a potential biological marker of autism and may help to define the phenotype, or major characteristics, of autism. UW colleagues think EEG techniques can be used on young children to help in the early detection of autism, which is critical in providing interventions for the disorder. Other members of the research team are from the UW's Autism Center and include Geraldine Dawson, center director and a professor of psychology; Sara Webb, assistant professor of psychiatry and behavioral sciences; Jessica Greenson, research scientist; and Kristen Merkle, research study assistant. The National Institute of Mental Health's Studies to Advance Autism Research and Treatment and the Perry Research Fellowship Endowment funded the research.

Autism, a spectrum of developmental disorders, is the most common developmental disorder in the United States. It is estimated to affect one in every 166 children. Autism is characterized by an inability to communicate and interact with other people, and those afflicted typically have a restricted range of activities and interests


'"/>

Source:University of Washington


Related biology news :

1. Drug That Tags Decision-making Areas Of The Brain May Aid
2. NYU Study Reveals How Brains Immune System Fights Viral Encephalitis
3. Transport System Smuggles Medicines Into Brain
4. Bird Brains Show How Trial and Error May Contribute to Learning
5. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
6. Wiley announces publication of Databasing the Brain
7. Scientists Propose Sweeping Changes to Naming of Bird Neurosystems to Acknowledge Their True Brainpower
8. Brain-mapping technique aids understanding of sleep, wakefulness
9. Some Brain Cells Change Channels To Fine-tune The Message
10. Brain Scans Reveal How Gene May Boost Schizophrenia Risk
11. Brain-injury rehabilitation depends on acetylcholine circuitry
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/1/2017)... IDTechEx Research, a leading provider of independent market research, ... a new report, Sensors for Robotics: Technologies, Markets and Forecasts ... ... Revenues ... "Sensors for Robotics: Technologies, Markets and Forecasts 2017-2027: Machine vision, force ...
(Date:1/30/2017)... FRANCISCO , Jan. 30, 2017   Invitae ... the fastest growing genetic information companies, today announced that ... financial results and provide 2017 guidance on Monday, February ... conference call that day at 4:45 p.m. Eastern / ... Invitae,s management team will briefly review financial results, guidance, ...
(Date:1/26/2017)... -- Acuity Market Intelligence today released the 2017 "Ten ... characterizes 2017 as a "breakout" year for biometrics ... new understanding of the potential benefits these technologies ... are often perceived as threats to privacy and ... Acuity Market intelligence. "However, taken together these technologies ...
Breaking Biology News(10 mins):
(Date:2/24/2017)... Feb. 24, 2017  VWR Corporation (NASDAQ: VWR), the leading ... and production customers, today reported its financial results for the ... Highlights: 4Q16 record quarterly net ... on an organic basis. 4Q16 ... organic basis, while the Americas net sales increased 2.5%, or ...
(Date:2/23/2017)... and NEW YORK , Feb. ... Lumeon , a leading digital health company, and ... provider of telemedicine and remote patient monitoring, announce ... telemedicine reimbursements.  DN Telehealth maximizes ... in real-time, extending consultations beyond a physical clinical ...
(Date:2/23/2017)... Madison, Wisconsin (PRWEB) , ... February 23, 2017 ... ... their Drug Discovery Services portfolio to include an array of biochemical ... clients with reliable data to drive their hit-to-lead and SAR programs, including inhibitor ...
(Date:2/23/2017)... SAN JOSE, Calif. , Feb. 23, 2017 ... an exclusive license for two key immunotherapy technologies ... The first technology provides a method to monitor ... therapy such as PD-L1 and CTLA-4.  The second ... detect if a patient is likely to have ...
Breaking Biology Technology: