Navigation Links
Brain protein improves stroke symptoms in rats, even when injected after 3 days

A protein naturally occurring in the brain improves recovery from stroke when injected up to three days after the onset of the stroke, and could be used as an effective stroke drug. A study in rats published today in the open access journal BMC Biology shows that an injection of Granulocyte-Colony Stimulating Factor (G-CSF), whose function in the brain is to control the formation of neurons and counteract neurone death, reduces the size of the area affected by a stroke by a third when injected four hours after the onset of the stroke. The study also shows that regular, delayed injections of G-CSF, starting up to three days after experimental stroke, are effective in restoring motor functions in rats.

G-CSF is known to improve recovery after a stroke, and it is currently being tested for use in humans. The BMC Biology study is the first to show that G-CSF can be effective when injected this late after a stroke event.

Armin Schneider from Sygnis Bioscience AG (formerly known as Axaron Bioscience AG) in Heidelberg, Germany, and Wolf-Rüdiger Schäbitz from the Neurology department in Münster, Germany, together with colleagues from the universities of Heidelberg and Erlangen, used rat models of two different types of stroke to assess the effect of an injection of G-CSF on recovery.

The first model was used to assess the impact of G-CSF on the size of the brain area affected by the stroke, which is identified by the presence of dead neurons. In this model, the animals were injected with a single dose of G-CSF at 60µg/kg body weight four hours after the stroke. The researchers demonstrate that the size of the affected area is reduced by 34.5% in the rats that received G-CSF four hours after the stroke.

The second model was used to assess the effect of G-CSF on the functional performance of the animals. In this model, the rats were injected 10 µg/kg body weight of G-CSF, starting 24 or 72 hours after the stroke, for a period of ten day s. Rats treated with G-CSF for ten days after the stroke performed significantly better in an exercise designed to test their physical abilities and coordination than rats that had been treated with placebo.
'"/>

Source:BioMed Central


Related biology news :

1. Drug That Tags Decision-making Areas Of The Brain May Aid
2. NYU Study Reveals How Brains Immune System Fights Viral Encephalitis
3. Transport System Smuggles Medicines Into Brain
4. Bird Brains Show How Trial and Error May Contribute to Learning
5. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
6. Wiley announces publication of Databasing the Brain
7. Scientists Propose Sweeping Changes to Naming of Bird Neurosystems to Acknowledge Their True Brainpower
8. Brain-mapping technique aids understanding of sleep, wakefulness
9. Some Brain Cells Change Channels To Fine-tune The Message
10. Brain Scans Reveal How Gene May Boost Schizophrenia Risk
11. Brain-injury rehabilitation depends on acetylcholine circuitry

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/9/2016)... TURKU, Finland , June 9, 2016 ... French National Police deploy Teleste,s video security solution to ensure ... France during the major tournament ... and data communications systems and services, announced today that its ... Police Prefecture to back up public safety across ...
(Date:6/2/2016)... --  The Weather Company , an IBM Business (NYSE: ... in which consumers will be able to interact with IBM ... voice or text and receive relevant information about the product ... have long sought an advertising solution that can create a ... and valuable; and can scale across millions of interactions and ...
(Date:5/20/2016)... , May 20, 2016  VoiceIt is excited ... with VoicePass. By working together, VoiceIt ...  Because VoiceIt and VoicePass take slightly different approaches ... increases both security and usability. ... about this new partnership. "This marketing ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... 24, 2016  Regular discussions on a range of subjects ... the two entities said Poloz. Speaking at a ... , he pointed to the country,s inflation target, which ... "In certain areas ... have common economic goals, why not sit down and address ...
(Date:6/24/2016)... ... 24, 2016 , ... While the majority of commercial spectrophotometers and fluorometers use ... 6000i models are higher end machines that use the more unconventional z-dimension of 20mm. ... from the bottom of the cuvette holder. , FireflySci has developed several Agilent ...
(Date:6/23/2016)... ... June 23, 2016 , ... Mosio, a ... eBook, “Clinical Trials Patient Recruitment and Retention Tips.” Partnering with experienced clinical research ... by providing practical tips, tools, and strategies for clinical researchers. , “The landscape ...
(Date:6/23/2016)...   Boston Biomedical , an industry leader ... target cancer stemness pathways, announced that its lead ... Designation from the U.S. Food and Drug Administration ... gastroesophageal junction (GEJ) cancer. Napabucasin is an orally ... stemness pathways by targeting STAT3, and is currently ...
Breaking Biology Technology: