Navigation Links
Brain-mapping technique aids understanding of sleep, wakefulness

The power of a new technique to map connections among nerve cells in the brain has a UT Southwestern Medical Center scientist dreaming of solving the mysteries of sleep.

By tracking which nerve cells in the mouse brain stimulate others, researchers in Japan and at UT Southwestern found that a type of neuron responsible for keeping animals awake receives inhibitory signals from neurons active only during sleep, as well as reinforcing, positive signals from nerve cells that are very active during wakefulness.

The findings, available online and appearing in the April 21 issue of the journal Neuron, shed light on the complex mechanisms involved in sleep regulation and may help to explain why once a person wakes up and moves around, he tends to stay awake.

"We all know subjectively and objectively that there is a very strong force regulating sleep, but there is very little knowledge about the actual biological mechanism controlling sleep," said Dr. Masashi Yanagisawa, professor of molecular genetics at UT Southwestern and senior author of the study. "Eventually my dream is to elucidate all the pathways regulating sleep."

Dr. Yanagisawa and his colleagues focused on neurons in the brain that produce the protein orexin, which helps keep animals awake. In humans, a lack of, or deficiency in, orexin causes narcolepsy, a rare disease in which people uncontrollably fall asleep, have excessive daytime sleepiness and experience sudden muscle weakness called cataplexy.

Because orexin-producing neurons play such a key role in regulating sleep, determining how they are connected to other neurons in the brain is an important step toward understanding how and why we sleep.

Mapping the neurons to which orexin neurons send signals has been relatively easy, Dr. Yanagisawa said, but determining which neurons send signals to orexin neurons has been a challenge. A brain-mapping technique developed recently by French scientists provided Dr. Yan
'"/>

Source:University of Texas Southwestern Medical Center at Dallas


Page: 1 2 3

Related biology news :

1. New lab technique identifies high levels of pathogens in therapy pool
2. Study reveals new technique for fingerprinting environmental samples
3. Researchers pioneer new gene therapy technique using natural repair process
4. Newer imaging techniques may lead to over-treatment
5. Gene silencing technique offers new strategy for treating, curing disease
6. Mosaic mouse technique offers a powerful new tool to study diseases and genetics
7. Researchers devise new technique for creating human stem cells
8. New technique rapidly detects illness-causing bacteria
9. New bioinformatics technique for systematically analyzing key regions in DNA that help control gene activity
10. New technique may speed DNA analysis
11. New technique helps identify multiple DNA regulatory sites
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Brain mapping technique aids understanding sleep wakefulness

(Date:9/21/2014)... working at the University of California, San Diego, have ... marks that control the activity of genes based on ... results from its application to human embryonic cells in ... September 21. , "All of our cells have the ... functions," said John Whitaker, lead author of the report. ...
(Date:9/19/2014)... Call it the Jimmy Durante of dinosaurs ... nasal profile. The new dinosaur, named Rhinorex ... University and Brigham Young University, lived in what ... during the Late Cretaceous period. , Rhinorex, which ... and a close relative of other Cretaceous hadrosaurs ...
(Date:9/19/2014)... species which over thousands of years has adapted to the ... that makes the cold dangerous for you. , This is ... and the cold provoking substance, called nonylphenol, comes from the ... suspected of being a endocrine disruptor, but when entering the ... ability to protect the cells in its body from cold ...
Breaking Biology News(10 mins):Program predicts placement of chemical tags that control gene activity 2New hadrosaur noses into spotlight 2Environmental pollutants make worms susceptible to cold 2Environmental pollutants make worms susceptible to cold 3
... Researchers have been unable to build an ideal photonic ... ultrafast optical computers. But now, University of Utah chemists ... with the ideal, diamond-like structure: They are found in ... Brazil. It appears that a simple creature like ...
... of the greatest zoological mysteries for over a century. ... puzzling crustaceans, despite the plethora of these larvae in ... what y- larvae grow up to be. A study ... reports the transformation of the larvae into a previously ...
... the Great Lakes have prompted the need to better ... collaborative project is aimed at improving information for beach ... close beaches to protect public health. This collaborative effort ... and other federal, state and local agencies. ...
Cached Biology News:The photonic beetle 2The photonic beetle 3The photonic beetle 4The photonic beetle 5Clue to mystery crustacean in parasite form 2To swim or not to swim? 2
(Date:9/19/2014)... CORAL SPRINGS, Florida , September 19, 2014 /PRNewswire/ ... biotech companies release latest developments, patents and results of ... (OTC: GNSZ), Eli Lilly and Company (NYSE: ... ), Celgene Corporation (NASDAQ: CELG ) and ... (OTCQB: GNSZ), a leader in developing prodrug therapeutics for ...
(Date:9/19/2014)... 2014 , The first grants ... Paediatric Endocrinology (ESPE) Meeting  Investment supports innovative ... in the field of growth  , EMD ... Germany , today announced the first recipients of ... awards were announced during a Satellite Symposium organized by ...
(Date:9/18/2014)... About POCT POCT, ... clinical laboratory. It helps in making fast clinical ... medication. POCT is gaining popularity due to the ... as diabetes, heart disease, and obesity. It is ... to minimize errors during the diagnosis of patients. ...
(Date:9/18/2014)... , September 18, 2014 ... ( http://www.researchandmarkets.com/research/czvg3s/biocompatible ) has announced the ... - Global Strategic Business Report" ... http://photos.prnewswire.com/prnh/20130307/600769) ,This report analyzes the worldwide ... Million by the following Product Segments: ...
Breaking Biology Technology:Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 2Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 3Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 4Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 5Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 6Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 7EMD Serono Awards Grant for Growth Innovation (GGI) for the First Time 2EMD Serono Awards Grant for Growth Innovation (GGI) for the First Time 3POCT Market in China 2014-2018 2Biocompatible Materials - Global Strategic Business Report 2014 2Biocompatible Materials - Global Strategic Business Report 2014 3
... a positive third,quarter, the biotech industry continued its upward climb ... the state of the economy,and interest rate jitters as the ... Index, for example, rose an impressive 6.1% in,October -- in ... ahead of the,DJIA which was unchanged. "Entering the final ...
... COLUMBIA, Md., Nov. 1 Martek Biosciences,Corporation (Nasdaq: ... in the United,States District Court in Wilmington, Delaware, ... a permanent injunction in Martek,s favor,against the defendants ... Lonza, Ltd., Nutrinova Inc. and Nutrinova Nutrition Specialties ...
... provide free home caregiving to disabled veterans, ... its,2007 We Care For Veterans campaign to honor ... qualified disabled veterans. (Logo: http://www.newscom.com/cgi-bin/prnh/20070521/LAM004ALOGO ) ... are,donating 20 hours each of free in-home care ...
Cached Biology Technology:Biotech Continues Upward Climb in October 2Biotech Continues Upward Climb in October 3Biotech Continues Upward Climb in October 4Martek to Obtain Permanent Injunction Against Lonza in U.S. Patent Infringement Suit; Jury Verdict on Infringement of Two of Three Patents Upheld by Judge 2Martek to Obtain Permanent Injunction Against Lonza in U.S. Patent Infringement Suit; Jury Verdict on Infringement of Two of Three Patents Upheld by Judge 3Homewatch CareGivers Launches 2007 We Care For Veterans Campaign 2
... intensely fluorescent and highly photostable FluoSpheres ... in a variety of applications requiring ... signal. Unfortunately, protein- and other macromolecule-labeled ... cause them to bind to non-target ...
Goat polyclonal to Duffy / FY / DARC...
SMVT (N-14)...
... Source: Tritirachium album Description: ... endopeptidase used in a wide range of applications ... peptide bonds mainly following the carboxyl group of ... and is classified as a serine protease. ...
Biology Products: