Navigation Links
Brain differences could explain why males and females experience pain relief differently

A study conducted by investigators at Georgia State University and the Atlanta-based Center for Behavioral Neuroscience (CBN) reports that anatomical and functional differences in the brain may explain sex differences in the experience of pain and in the effects of certain drugs on pain.

The finding, reported in the April 13 issue of the Journal of Comparative Neurology, is the first report of specific differences in the parts of the brain responsible for the transmission of pain sensations in the body. The study used rat brains, but a host of clinical evidence suggests that similar differences occur in humans ?in other words, this finding could eventually lead to the development of differential treatments for pain in men versus women.

A team led by Dr. Anne Murphy of the Georgia State Department of Biology and the CBN showed that male and female rodents are anatomically different in the area of the brain called the periaqueductal gray (PAG). This region of the brain relays information regarding pain to another brain region, the rostral ventral medulla (RVM). This PAG-RVM circuit is the main pain circuit in the brain, and is responsible for the sensation of pain. Both narcotics and analgesics work by acting on these brain regions. Interestingly, while thousands of studies have been conducted examining the role of the PAG and the RVM in pain and analgesia, these studies were conducted exclusively in males. The study by Murphy is the very first to examine if these brain regions are organized anatomically in a similar manner in females. In addition to sex differences in how the PAG is organized anatomically, the team went on to show that persistent pain activates this pathway differently in males and females. Specifically, the scientists showed that inflammatory pain activated the PAG-RVM circuit to a greater degree in males than in females. Morphine ?an opioid drug or narcotic - reduced the response of this circuit to pain to in males, but not
'"/>

Source:Georgia State University


Page: 1 2

Related biology news :

1. Drug That Tags Decision-making Areas Of The Brain May Aid
2. NYU Study Reveals How Brains Immune System Fights Viral Encephalitis
3. Transport System Smuggles Medicines Into Brain
4. Bird Brains Show How Trial and Error May Contribute to Learning
5. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
6. Wiley announces publication of Databasing the Brain
7. Scientists Propose Sweeping Changes to Naming of Bird Neurosystems to Acknowledge Their True Brainpower
8. Brain-mapping technique aids understanding of sleep, wakefulness
9. Some Brain Cells Change Channels To Fine-tune The Message
10. Brain Scans Reveal How Gene May Boost Schizophrenia Risk
11. Brain-injury rehabilitation depends on acetylcholine circuitry
Post Your Comments:
(Date:12/15/2014)... Dec. 12, 2014 Research and Markets ... of the "Global Facial Recognition Market 2015-2019" ... http://photos.prnewswire.com/prnh/20130307/600769 Facial recognition ... individuals. Facial recognition system measures the overall facial ... edges, mouth, and the distance between eyes. Facial ...
(Date:12/11/2014)... 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/9ql3kr/biometrics_market ) has announced the addition of ... report to their offering. One ... adoption of multimodal biometric systems. Multimodal biometric systems ... for verification and identification purposes. This helps to ...
(Date:12/11/2014)... 10, 2014  Data Sciences International (DSI), the ... a new series of digital telemetry implants to ... M series, part of the PhysioTel™ Digital platform, ... possible physiologic data when incorporating functional endpoints into ... to toxicology studies has evolved from short ECG ...
Breaking Biology News(10 mins):Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2New telemetry implants expected to change how large animal toxicology studies are conducted 2
... Japan -- In what may prove to be a ... gasses has just become considerably easier. Using a ... Kyoto University,s WPI Institute for Integrated Cell-Material Sciences (iCeMS) ... of low cost, high efficiency separation. The process ...
... MADISON, WI June 22, 2012 Buttery shrimp. Fried ... be a biological reason why fatty and cholesterol-rich foods are ... than 40 years that dietary fat promotes cholesterol uptake, but ... Ph.D., and his colleagues at the Carnegie Institution for Science ...
... asks children who have each been assigned a wetland plant ... other "organisms" their assigned plant or animal interacts with in ... the teacher describes an event that affects one "organism." That ... tug then tug on their strings in turn. The ...
Cached Biology News:Faster, cheaper gas and liquid separation using custom designed and built mesoscopic structures 2Zebrafish research shows how dietary fat regulates cholesterol absorption 2Foundational concept of ecology tested by experiment 2Foundational concept of ecology tested by experiment 3Foundational concept of ecology tested by experiment 4
(Date:12/19/2014)... (PRWEB) December 19, 2014 Bioject ... developer and manufacturer of needle-free injection technology, today ... with Immunomic Therapeutics, Inc. (“ITI”) for ITI to ... with its LAMP™ vaccine platform. , In ... exclusive Worldwide license to the Biojector®-2000 that triggers ...
(Date:12/19/2014)... 2014 Charm Sciences is pleased to ... Detection of Aflatoxin M1 in raw commingled milk is ... party validation. The peer reviewed report of the validation ... for Agricultural and Fisheries Research (ILVO-T&V) has been published ... B1, the most toxic aflatoxin and a known carcinogen, ...
(Date:12/19/2014)... 2014 BioPlus Specialty Pharmacy ... the promotion of Nick Maroulis, Pharm.D. to the newly ... , In this position, Dr. Maroulis will continue ... the directors of our multi-site pharmacies as the company ... and during that time he has served in many ...
(Date:12/19/2014)... Naurex Inc., a biopharmaceutical company leveraging its ... the central nervous system, today announced that Norbert ... present at the 33 rd annual J.P. Morgan ... 3:00 p.m. PST on Tuesday, January 13, 2015, at ... Calif. About Naurex Inc. ...
Breaking Biology Technology:Bioject and Immunomic Therapeutics Enter into an Agreement for License of Needle-Free Technology for LAMP-vax Vaccines 2Bioject and Immunomic Therapeutics Enter into an Agreement for License of Needle-Free Technology for LAMP-vax Vaccines 3Charm Sciences Achieves Independent Validation of First 15 Minute Quantitative Screening Method for Aflatoxin M1 2BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2Naurex to Present at 33rd Annual J.P. Morgan Healthcare Conference 2
... (NYSE: SGP ) is scheduled to announce its sales ... 21, 2009. , , At approximately 7:45 a.m. ... review results for the 2009 second quarter. Fred Hassan, Schering-Plough,s ... conference call. , , To listen live to the ...
... Ind., June 29 Hill-Rom (NYSE: HRC ) ... relating to Negative Pressure Wound Therapy (NPWT) to Kinetic Concepts, ... included U.S. and foreign patents and patent applications covering innovations ... effective immediately. Terms were not disclosed. , , ...
... SAN MATEO, Calif., June 29 NeurogesX, Inc. ... been added to the broad-market Russell 3000(R) and small-cap Russell(R) ... market June 26, 2009 when Russell Investments reconstituted its U.S. ... of Russell,s U.S. indexes captures the 4,000 largest U.S. stocks ...
Cached Biology Technology:Schering-Plough Schedules Conference Call Webcast for 2009 Second Quarter Earnings 2Hill-Rom Announces Sale of Negative Pressure Wound Therapy Intellectual Property 2Hill-Rom Announces Sale of Negative Pressure Wound Therapy Intellectual Property 3NeurogesX Added to Russell 3000 Index 2NeurogesX Added to Russell 3000 Index 3NeurogesX Added to Russell 3000 Index 4
... Goat anti-Human Alpha 1 ... sodium azide Goats were ... Alpha-1-acid glycoprotein in Freund's adjuvant. ... phase absorbed to ensure specificity. ...
Purified Mouse anti-Hu p120 Catenin (pT916) Storage Temperature: Refrigerate(2 to 8C)...
synphilin-1 (V-19)...
Anti-OSMR Monoclonal Antibody Research Focus: cytokine/growth factor Storage: 4C Shipping Temperature: 4C...
Biology Products: