Navigation Links
Brain Scans Reveal How Gene May Boost Schizophrenia Risk

Clues about how a suspect version of a gene may slightly increase risk for schizophrenia* are emerging from a brain imaging study by the National Institutes of Health's (NIH) National Institute of Mental Health (NIMH). The gene variant produced a telltale pattern of activity linked to production of a key brain messenger chemical.

The study found that increased activity in the front of the brain predicted increases in the neurotransmitter dopamine in the middle of the brain in subjects with the suspected schizophrenia-related version of the gene. Yet, the opposite relationship held for subjects with the other of two common versions of the gene.

"A tiny variation in the gene that makes the enzyme that breaks down dopamine causes a complete flipflop ?not a mere difference in degree ?in dopamine activity in these two brain areas," explained NIMH's Dr. Andreas Meyer-Lindenberg, who, along with Dr. Karen Berman and colleagues, reported their findings in the April 10, 2005 online edition of Nature Neuroscience.

The NIMH study also for the first time confirms in living humans that activity of the front brain area, the prefrontal cortex, is regulated by dopamine production in the midbrain, which, in turn, is regulated by these two common gene variants.

Schizophrenia, a severe mental illness marked by hallucinations and delusions, affects one percent of the population and is treated with antipsychotic drugs that block dopamine. The prefrontal cortex is critical for motivation, learning in response to reward, and working memory ?functions impaired in schizophrenia, which is thought to involve a dopamine imbalance.

Individuals inherit two copies (one from each parent) of the gene for the enzyme catecho-O-methyltransferase (COMT), which chemically breaks down dopamine. It comes in two versions, val and met, so a person can have two of the same version or one of each. Since it results in considerably weaker enzyme action, people with the met
'"/>

Source:NIH


Page: 1 2 3

Related biology news :

1. Drug That Tags Decision-making Areas Of The Brain May Aid
2. NYU Study Reveals How Brains Immune System Fights Viral Encephalitis
3. Transport System Smuggles Medicines Into Brain
4. Bird Brains Show How Trial and Error May Contribute to Learning
5. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
6. Wiley announces publication of Databasing the Brain
7. Scientists Propose Sweeping Changes to Naming of Bird Neurosystems to Acknowledge Their True Brainpower
8. Brain-mapping technique aids understanding of sleep, wakefulness
9. Some Brain Cells Change Channels To Fine-tune The Message
10. Brain-injury rehabilitation depends on acetylcholine circuitry
11. Brain May Be Less Plastic Than Hoped
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Brain Scans Reveal How Gene May Boost Schizophrenia Risk

(Date:4/2/2015)... At its 2015 ACMG Annual Clinical Genetics ... the American College of Medical Genetics and Genomics (ACMG) ... Board.  Members of the ACMG Board of Directors serve ... advancing its policies and programs. ACMG is the national ... an eventful time in medical genetics and genomics.  We ...
(Date:4/1/2015)... --  Medisafe ™, the leading global medication management platform ... and Android smartphones and tablets, announces today ... to allow patients to track and correlate their adherence ... will be able to visualize in real-time how taking ... as glucose levels and blood pressure. "Patients ...
(Date:3/26/2015)... -- The Granite Club, Canada,s ... today announced it has implemented a state-of-the-art access and ... members and staff, while restricting access to authorized users ... FST,s IMID Access system because it has the perfect ... staff, in addition to unparalleled security," said James ...
Breaking Biology News(10 mins):American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 2American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 3American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 4American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 5American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 6American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 7American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 8Medisafe Announces Launch of Biometric Integration, Enabling Patients to Stay Adherent to Their Meds and See Tangible Health Results 2Granite Club First Private Club in North America to Implement FST Biometrics Secure Access Solution, as Part of Multi-million Dollar Expansion 2
... Fred Kraus from Bishop Museum, Honolulu has ... makes them the world,s smallest tetrapods (non-fish vertebrates). The frogs belong ... extremely small, with adults of the two new species - named ... 8-9 mm in length. The study was published in the open ...
... could be helped with alternative scanning techniques that provide ... University of Edinburgh used an imaging technique that could ... to replace their heart valves, and improve treatments to ... the heart,s aortic valve a common condition known ...
... Dec. 12, 2011  The Evermedia Group, Inc. (Pinksheets: ... Markets last month, raising the Company,s listing from ... Current Information tier, the highest level of reporting ... Evermedia submitted an Initial Company Information and Disclosure ...
Cached Biology News:World's smallest frogs discovered in New Guinea 2New scanning strategy could help develop heart disease treatments 2The Evermedia Group, Inc. Advances Corporate Transparency Efforts 2The Evermedia Group, Inc. Advances Corporate Transparency Efforts 3
(Date:5/5/2015)... The Alliance for Clinical Research Excellence ... in the public interest, and Texas-based for-profit San ... Company, have formed a strategic alliance to create a ... across the healthcare and clinical research endeavor. The ... and the public to be clearly heard in this ...
(Date:5/4/2015)... Research Inc., a Montreal based Contract Research ... Neeman International (MNI), with head office in New Delhi, ... Bangalore , Chennai and ... is located North Carolina, USA . ... transaction into JSS with Capital Croissance PME (CCPME), a joint fund ...
(Date:5/4/2015)... TEL AVIV, Israel , May 4, 2015 /PRNewswire/ ... has filed its annual report on Form 20-F for ... U.S. Securities and Exchange Commission ("SEC"). The annual report ... for the development of antibodies in the area of ... antibodies with superior qualities of high specificity and binding ...
(Date:5/4/2015)... /PRNewswire/ - The Fight Against Cancer Innovation Trust ... the formation of Turnstone Biologics Inc. (Turnstone), a ... that harness the patient,s own immune system. ... the Children,s Hospital of Eastern Ontario ... Ontario Institute for Cancer Research (OICR), the Ottawa ...
Breaking Biology Technology:ACRES and San Antonio Express-News Launch Blog on Accountability in Clinical Research 2ACRES and San Antonio Express-News Launch Blog on Accountability in Clinical Research 3ACRES and San Antonio Express-News Launch Blog on Accountability in Clinical Research 4JSS Medical Canada widens its global presence across Asia/Pacific region 2JSS Medical Canada widens its global presence across Asia/Pacific region 3JSS Medical Canada widens its global presence across Asia/Pacific region 4Tikcro Technologies Files Annual Report on Form 20-F for the Year Ended December 31, 2014 2Turnstone Biologics Inc. to accelerate clinical and commercial translation of cancer immunotherapies 2Turnstone Biologics Inc. to accelerate clinical and commercial translation of cancer immunotherapies 3
... Md., Jan. 11, 2012 PharmAthene, Inc. (NYSE Amex: ... biological and chemical threats, announced today that Eric I. Richman, ... Financial Capital Markets Eighth Annual Equity Conference on Tuesday, January ... 2 at the Hard Rock Hotel, Hollywood Florida.  ...
... 2012  goBalto, developer of new generation web-based clinical ... FDA 21 CFR Part 11 compliance audit of ... Tracker,s successful audit will help both sponsors / ... trials comply with FDA rules and regulations governing ...
... MA Researchers at Brigham and Women,s Hospital (BWH) have ... that has the ability to "swim" through the body and ... of the human body. The capsule is designed to ... a camera. Once inside the patient,s digestive track, a ...
Cached Biology Technology:PharmAthene to Present at the Noble Financial Eighth Annual Equity Conference on Tuesday, January 17, 2012 2goBalto Completes a Successful FDA 21 CFR Part 11 Compliance Audit 2
Screening assay to detect the Listeria monocytogenes in food samples by,DNA amplification and molecular hybridization on a microtiter plate....
... Application: Acridine orange has been used ... in agarose and polyacrylamide gels. Acridine orange ... detect purified DNA in gels with a ... has also been used extensively for cell ...
Miscellaneous: Versatile stain for staining RNA (bluish-purple), DNA (blue), proteins (red) and acid polysaccharides Assay: ~ 95 % Suitab tst: differential staining of nucleic acids and prote...
...
Biology Products: