Navigation Links
Brain Scans Reveal How Gene May Boost Schizophrenia Risk

Clues about how a suspect version of a gene may slightly increase risk for schizophrenia* are emerging from a brain imaging study by the National Institutes of Health's (NIH) National Institute of Mental Health (NIMH). The gene variant produced a telltale pattern of activity linked to production of a key brain messenger chemical.

The study found that increased activity in the front of the brain predicted increases in the neurotransmitter dopamine in the middle of the brain in subjects with the suspected schizophrenia-related version of the gene. Yet, the opposite relationship held for subjects with the other of two common versions of the gene.

"A tiny variation in the gene that makes the enzyme that breaks down dopamine causes a complete flipflop ?not a mere difference in degree ?in dopamine activity in these two brain areas," explained NIMH's Dr. Andreas Meyer-Lindenberg, who, along with Dr. Karen Berman and colleagues, reported their findings in the April 10, 2005 online edition of Nature Neuroscience.

The NIMH study also for the first time confirms in living humans that activity of the front brain area, the prefrontal cortex, is regulated by dopamine production in the midbrain, which, in turn, is regulated by these two common gene variants.

Schizophrenia, a severe mental illness marked by hallucinations and delusions, affects one percent of the population and is treated with antipsychotic drugs that block dopamine. The prefrontal cortex is critical for motivation, learning in response to reward, and working memory ?functions impaired in schizophrenia, which is thought to involve a dopamine imbalance.

Individuals inherit two copies (one from each parent) of the gene for the enzyme catecho-O-methyltransferase (COMT), which chemically breaks down dopamine. It comes in two versions, val and met, so a person can have two of the same version or one of each. Since it results in considerably weaker enzyme action, people with the met
'"/>

Source:NIH


Page: 1 2 3

Related biology news :

1. Drug That Tags Decision-making Areas Of The Brain May Aid
2. NYU Study Reveals How Brains Immune System Fights Viral Encephalitis
3. Transport System Smuggles Medicines Into Brain
4. Bird Brains Show How Trial and Error May Contribute to Learning
5. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
6. Wiley announces publication of Databasing the Brain
7. Scientists Propose Sweeping Changes to Naming of Bird Neurosystems to Acknowledge Their True Brainpower
8. Brain-mapping technique aids understanding of sleep, wakefulness
9. Some Brain Cells Change Channels To Fine-tune The Message
10. Brain-injury rehabilitation depends on acetylcholine circuitry
11. Brain May Be Less Plastic Than Hoped
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Brain Scans Reveal How Gene May Boost Schizophrenia Risk

(Date:7/23/2014)... risk warning for Yellowknife and surrounding area because of ... In the image taken by the Aqua satellite, ... Fire is an obvious health hazard, but the ... obvious and its effects are insidious. , The smoke ... structure, tires, waste or wood burning) is a mixture ...
(Date:7/23/2014)... Roughly 780 million people around the world have no ... Health Organization (WHO), 3.4 million people die from water-related ... the goal of making a contribution to solving this ... Wendelin Stark, head of the Functional Materials Laboratory, the ... developing a prototype. , "What makes our DrinkPure filter ...
(Date:7/23/2014)... Worldwide Innovative Networking in personalized cancer medicine, (the WIN ... at Thomas Jefferson University will be one ... of this prestigious group in the Tri-State Area. The ... innovative personalized medicine to the patient by forging collaborations ... "Our participation in the WIN consortium means Jefferson cancer ...
Breaking Biology News(10 mins):ETH student develops filter for clean water around the world 2New partnership brings more personalized cancer treatment to Philadelphia 2
... engineers and sleep medicine specialists from two Michigan ... put innovative quantitative analysis, signal-processing technology and computer ... One of their recent findings is that a ... distinguish fibromyalgia patients from healthy controls. ...
... BETHESDA, Md. (Sept. 3, 2008) Mice given quercetin, ... were less likely to contract the flu, according to ... study also found that stressful exercise increased the susceptibility ... that negative effect. Quercetin, a close chemical relative ...
... widely cultivated crop that has been subjected to intensive ... years ago). The domestication of grapevine has undergone a ... The recent publication of the complete grapevine genome ... its content. This sequencing has shown that genes constitute ...
Cached Biology News:What a sleep study can reveal about fibromyalgia 2What a sleep study can reveal about fibromyalgia 3Substance found in fruits and vegetables reduces likelihood of the flu 2Substance found in fruits and vegetables reduces likelihood of the flu 3
(Date:7/23/2014)... , July 23, 2014 regulated information -- UCB ... and development pipeline with positive topline results from ... . This study was designed to evaluate the efficacy ... 200 mg/day, without titration) compared to placebo, as ... partial-onset seizures, not fully controlled despite treatment with ...
(Date:7/23/2014)...  Sofinnova Ventures, a Menlo Park ... Sofinnova Venture Partners IX, L.P. at the hard cap ... fund target of $425 million. Sofinnova focuses ... with recent funds, SVP IX will provide capital primarily ... with select investments in earlier stage opportunities. Investments will ...
(Date:7/23/2014)... 23, 2014 OncLive® is pleased ... has joined its Strategic Alliance Partnership program. ... program, UNC Lineberger will have the opportunity to ... of its cutting-edge research initiatives, community-directed cancer prevention ... will work with OncLive to educate their peers ...
(Date:7/23/2014)... July 23, 2014 Astra ... and comprehensive consultancy and pharma training services, and ... Safety (ACRES) , a non-profit integrating the expertise ... and maintain a global system for clinical trials, ... to improve the expertise of industry professionals through ...
Breaking Biology Technology:Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 2Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 3Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 4Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 5Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 6Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 7Sofinnova Raises $500 Million Biotech Venture Fund 2OncLive Expands Its Strategic Alliance Partnership Program With the Addition of UNC Lineberger Comprehensive Cancer Center 2OncLive Expands Its Strategic Alliance Partnership Program With the Addition of UNC Lineberger Comprehensive Cancer Center 3Astra Nova and ACRES Partner on Quality and Access of Training for Research Professionals 2Astra Nova and ACRES Partner on Quality and Access of Training for Research Professionals 3
... , Italian , Japanese and Chinese . ... University of Bristol has developed a new approach to quantum computing ... be done by today,s computers. Scientists from Bristol,s Centre ... used to perform complex calculations and simulations using quantum particles in ...
... NEW YORK, Sept. 16 The 16th Annual National ... Vegas, November 30 – December 3, will focus on ... a time of economic recovery. ErgoExpo,s core educational topics ... workforce, and safety will be coupled with tracks specifically ...
... PRINCETON, N.J., Sept. 16 Novo Nordisk Inc. has been selected ... one of the nation,s top companies for family-friendly benefits. Earlier this ... "100 Best Companies to Work For" and NJBiz,s "Best ... Companies, family programs adeptly help employees in all areas of their ...
Cached Biology Technology:Optical chip enables new approach to quantum computing 2Optical chip enables new approach to quantum computing 32010 National Ergonomics Conference Coming To Las Vegas, Nov. 30 - Dec. 3 With Larger Expo; 22010 National Ergonomics Conference Coming To Las Vegas, Nov. 30 - Dec. 3 With Larger Expo; 32010 National Ergonomics Conference Coming To Las Vegas, Nov. 30 - Dec. 3 With Larger Expo; 4Novo Nordisk Named a 2010 Working Mother 100 Best Company 2Novo Nordisk Named a 2010 Working Mother 100 Best Company 3
... bath, with a comprehensive array of accessories. ... baths with seamless, splash-water protected keypad offer ... (LED) indicating up to 6 temperature values ... MICROPROCESSOR technology with PID temperature control eliminates ...
... Provides a buffered anti-freeze environment for ... Maintains a liquid, low viscosity solution at ... is necessary and sampling is convenient ... during long-term storage Protect enzyme conjugates ...
This buffer is Specifically formulated to be used with Endogen's Poly-HRP Streptavidin...
... SearchLight® Array Analyst Software has been ... arrays. Mathematical algorithms allow the software to ... spot within each well of an ELISA ... SearchLight® Array Analyst Software has been customized ...
Biology Products: