( destabilizes Dx in the presence of Notc...)Bound for destruction: Ubiquitination protects against improper Notch signaling

destabilizes Dx in the presence of Notch. This competition between two ubiquitin ligases to permit or suppress activation of a signaling pathway represents a neat solution to the problem confronting cells of how to prevent molecular loose cannons from fouling their precisely ordered workplans.
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Source:Riken Center for Developmental Biology


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