Navigation Links
Botox could help target resistant tumors for treatment

ce to radiotherapy, and is a determining factor in the poor prognosis of tumors to cytotoxic treatments," said Gallez. "Botulinum toxin could lead to inhibition of contractions of tumor vessels, improve tumor perfusion and oxygenation, and enhance the response of tumors to radio- and chemotherapy."

Botulinum toxin is a naturally occurring molecule, and historically has been implicated with intestinal poisonings. It has been developed for several clinical applications, including facial spasms, strabismus (a disease of the eye muscles), and other muscle hyperactivity. It also has become popularly known as Botox for its cosmetic uses on the face.

The toxin acts on the nervous system by blocking the release of neurotransmitters, particularly acetylcholine and norepinephrine. Gallez and his colleagues hypothesized that since Botulinum toxin impeded neurotransmitter release in the sympathetic nervous system, it could prevent neuromuscular contractions of vessels in tumors. The inhibition of this contraction could literally open the gate to improved tumor perfusion by chemotherapeutic drugs and oxygenation that enhances radiotherapy.

The scientists used two tumor models, one for fibrosarcoma and the other for mouse liver tumor. Botox was injected into the tumor once it had grown to about 6 mm. The tumors were then examined for three days, for vascular and perfusion changes as well as responses to anti-cancer therapies. In tests on oxygenation, cellular oxygen pressure was shown to significantly increase after treatment by Botox in both types of tumors. In tests on perfusion, magnetic resonance imaging results (MRI) showed significantly greater perfusion in treated mice after three days.

In addition, Botox "pre-treatment" led to significantly greater delays in tumor growth as well as stimulation of apoptosis (programmed cellular death) when compared by irradiation without Botox. The combination of Botox and the chemotherapeutic agent cy
'"/>

Source:American Association for Cancer Research


Page: 1 2 3

Related biology news :

1. Protein discovery could unlock the secret to better TB treatment
2. Tiny particles could solve billion-dollar problem
3. First atlas of key brain genes could speed research on cancer, neurological diseases
4. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
5. A comprehensive response to HIV could prevent 10 million AIDS deaths in Africa by 2020
6. How the environment could be damaging mens reproductive health
7. Dead zone area in Gulf could be increasing, researchers say
8. Growth in biomass could put US on road to energy independence
9. Nano-bumps could help repair clogged blood vessels
10. Researchers develop assay that could be applied to drug screening
11. Currents could disrupt ocean food chain
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Botox could help target resistant tumors for treatment

(Date:8/19/2014)... must be made to decrease China,s increasing caesarean section ... in BJOG: An International Journal of Obstetrics and ... highest caesarean delivery rates in the world. Of 16 ... caesarean. Although the exact rate is not known, the ... reports total caesarean rates ranging from 36% to 58%. ...
(Date:8/19/2014)... 19, 2014 To improve students, chances of ... the University of Houston (UH) implemented a comprehensive ... at risk for failure. , Through a ... (THECB), the Department of Biology and Biochemistry embarked ... taking "General Biology" for non-majors and "Introductory Biology" ...
(Date:8/19/2014)... rating systems be used in supermarkets to encourage healthier ... sought to answer that very question by tracking the ... Guiding Stars System to rate the nutritional value of ... and Brand Lab,s David Just, PhD, and Brian Wansink ... sales records of over 150 Hannaford Supermarkets in the ...
Breaking Biology News(10 mins):Is China's 50 percent cesarean section delivery rate too high? 2Is China's 50 percent cesarean section delivery rate too high? 3University of Houson program earns kudos for improving grades, retaining students 2University of Houson program earns kudos for improving grades, retaining students 3
... COLUMBUS, Ohio Insulin resistance, the hallmark of type ... is paradoxically also an apparent contributor to muscle wasting ... to new research. And in an animal study, ... progression of muscle wasting and fat loss, the main ...
... Biological Sciences Research Council (BBSRC)-funded research, published this week ... discovered molecules that could confuse insects, ability to detect ... could reduce damage to crops by insect pests and ... Hooper of Rothamsted Research, an institute of BBSRC said: ...
... highly complex, research to understand how people fight infection ... simpler organisms. Zebrafish are becoming an important model for ... manipulated and many fundamental processes between zebrafish and humans ... highly amenable to drug screening assays. The functional similarity ...
Cached Biology News:Diabetes drug shows promise in fighting lethal cancer complication 2Diabetes drug shows promise in fighting lethal cancer complication 3Scientists discover how to send insects off the scent of crops 2Fish fend off invading germs with an initial response similar to the one found in people 2
(Date:8/18/2014)... Diagnostics Inc. (TSX-V: SQD), a life sciences company that ... microarray diagnostics, today announced it will hold an investor ... ET.  During the call, Andrew ... SQI,s recent commercialization progress and then introduce Dr. ... to the Board of Directors of SQI and also ...
(Date:8/18/2014)... efficiency and data storage may someday run ... polarizations to read and write digital information, ... technology. But ferroelectrics must first overcome a ... habit of "forgetting" stored data. , ... Energy,s Brookhaven National Laboratory have discovered nanoscale ...
(Date:8/18/2014)... 18, 2014 According to ... By Application (Municipal Wastewater Treatment and Industrial Wastewater ... Multi Tubular), By Configuration (Internal/Submerged and External/Sidestream), and ... MarketsandMarkets, The market for membrane bioreactor systems is ... at a CAGR of 15.28% between 2014 and ...
(Date:8/18/2014)... 2014 China is increasingly being ... clinical research industry. Clinicaltrial.gov statistics highlight the popularity ... aging population; a high increase in infectious diseases; ... populated pool of patients and a track record ... points, China also presents challenges for the clinical ...
Breaking Biology Technology:SQI Diagnostics Announces Investor Conference Call with Dr. Allan Pronovost 2SQI Diagnostics Announces Investor Conference Call with Dr. Allan Pronovost 3Promising ferroelectric materials suffer from unexpected electric polarizations 2Promising ferroelectric materials suffer from unexpected electric polarizations 3Promising ferroelectric materials suffer from unexpected electric polarizations 4Membrane Bioreactor Systems Market Worth $2,927 Million by 2019 2Membrane Bioreactor Systems Market Worth $2,927 Million by 2019 3China – Land of Opportunities & Challenges for the Clinical Research Industry, New Webinar Hosted by Xtalks 2
... with antibodies that react to the sample. The test result can ... either does or does not appear depending on the sample ... consumers. It is also possible to print instructional images or text, ... can be used to test quickly and easily for the presence ...
... producing nanoscopic crystals of a pharmaceutical product can allow the ... drug is not soluble in water. Research suggests that ... the pharmaceutical industry dissolve only very weakly in water, if ... drugs as it means they are not effective if taken ...
... and interact.  That,s the marketing mantra at ... creator of the best-selling children,s FireFly™ ... of the Binaca™ brand.   ...   http://www.newscom.com/cgi-bin/prnh/20101006/LA77977LOGO ) The company has ...
Cached Biology Technology:VTT printed hemoglobin test on paper 2Nano drugs 2A 'Fresh' Approach to Marketing: Dr. Fresh™, Inc. Goes Guerilla With Internet-Based Campaigns 2
Mouse polyclonal antibody raised against a partial recombinant RDH5. NCBI Entrez Gene ID = 5959...
Mouse monoclonal antibody raised against a partial recombinant KRT4. NCBI Entrez Gene ID = KRT4...
Mouse monoclonal antibody raised against a partial recombinant ARHGEF11. NCBI Entrez Gene ID = ARHGEF11...
... PrecisION Ion Channel Cell Lines ,High Quality, ... channels are well known for having a ... and consequently have a key function in ... modulate ion channels have been investigated in ...
Biology Products: