Navigation Links
Boston University biomedical engineers win major grant for pursuit of the '$1,000 Genome'

Two Boston University biomedical engineers have won a major National Institutes of Health (NIH) grant to continue groundbreaking research aimed at reducing the cost of sequencing individual human genomes to about $1,000.

Boston University Associate Professor of Biomedical Engineering and Physics Amit Meller was among nine researchers chosen for the NIH's National Human Genome Research Institute "$1,000 Genome" grants nationally. Meller and co-principal investigator Zhiping Weng, also a BU biomedical engineer, won $2.2 million over the next three years for their research, in addition to some $600,000 Meller has already received from NIH for this work.

Meller is using novel methods to decode the sequence of bases on a DNA strand at the molecular level. Using beams of electrons, Meller punches tiny holes in thin silicon films, then pulls strands of DNA through these "nanopores" using an electric current. Each base is identified by a florescent marker attached to it, which allows the researchers to record the sequence of bases as the strand emerges from the nanopore. Meller has devised a system of lasers and highly sensitive detectors which greatly increase the process' resolution. He is the only researcher in the world using this method, which he names "Opti-Pore."

Weng's involvement centers on bioinformatics ?using computational methods to organize the large amount of data collected.

Meller said he is grateful for the grant, which validates his approach to DNA sequencing. "We are very close to a proof of principle that we can read a small number of these bases, perhaps six or eight, using this method," said Meller. "From there, it is a small step to reading tens, and later hundreds, at a time. That would produce an orders-of-magnitude reduction in the cost of sequencing individuals' DNA."

According to NIH, sequencing the 3 billion base pairs on a human genome using current technology costs about $10 million. Reducing the cos t to $1,000 or less would bring DNA sequencing into the realm of routine medical care, enabling doctors to diagnose and treat patients more effectively based on their individual genetic profiles.


'"/>

Source:Boston University


Related biology news :

1. University of Manchester makes made-to-measure skin and bones a reality using inkjet printers
2. New protein discovered by Hebrew University researchers
3. Next Generation Body Scanner Launched By The University Of Manchester
4. Roundup®highly lethal to amphibians, finds University of Pittsburgh researcher
5. Green catalyst destroys pesticides and munitions toxins, finds Carnegie Mellon University
6. University of Nevada, Reno research team discovers hormone that causes malaria mosquito to urinate
7. Carnegie Mellon University research reveals how cells process large genes
8. University of Delaware researchers develop cancer nanobomb
9. University of Arizona plant scientists to unravel maize genome
10. Team led by Carnegie Mellon University scientist finds first evidence of a living memory trace
11. University of Utah to help build bionic arm
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/6/2017)... DENVER , Feb. 6, 2017 ... national security are driving border authorities to continue ... Acuity reports there are 2143 Automated Border Control ... Kiosks currently deployed at more than 163 ports ... between 2013 to 2016 achieving a combined CAGR ...
(Date:2/2/2017)... , Feb. 2, 2017  EyeLock LLC, a market ... new white paper " What You Should Know About ... of ensuring user authenticity is a growing concern. In ... of users. However, traditional authentication schemes such as username/password ... Biometric authentication offers an elegant solution to the ...
(Date:1/30/2017)... 30, 2017   Invitae Corporation (NYSE: ... information companies, today announced that it will report its ... 2017 guidance on Monday, February 13, 2017, and Invitae,s ... at 4:45 p.m. Eastern / 1:45 p.m. Pacific. ... briefly review financial results, guidance, and recent developments and ...
Breaking Biology News(10 mins):
(Date:2/22/2017)... ... February 22, 2017 , ... ... medical education provider of women’s health, primary care, and specialty education, announced ... Continuing Medical Education (ACCME). ACCME’s Accreditation with Commendation is a six-year accreditation ...
(Date:2/22/2017)... , Feb. 22, 2017 Origin (Origin Agritech, LLC, a ... and seed provider, and Arcadia (Arcadia Biosciences, ... develops and commercializes agricultural productivity traits and nutritional products, today announced ... biotechnology product developed in China to ... trials. ...
(Date:2/22/2017)... TRIANGLE PARK, N.C., Feb. 22, 2017  United Therapeutics ... its financial results for the fourth quarter and ... 2016 financial results reflect continued growth as net ... million," said Martine Rothblatt, Ph.D., United Therapeutics, Chairman ... our ability to develop and advance our growing ...
(Date:2/21/2017)... , ... February 21, 2017 , ... ... biotech research and development (R&D), today announced the establishment of Genedata Limited as ... Director Kevin Teburi, a recognized expert in life science informatics. Creating the UK ...
Breaking Biology Technology: