Navigation Links
Boston University biomedical engineers win major grant for pursuit of the '$1,000 Genome'

Two Boston University biomedical engineers have won a major National Institutes of Health (NIH) grant to continue groundbreaking research aimed at reducing the cost of sequencing individual human genomes to about $1,000.

Boston University Associate Professor of Biomedical Engineering and Physics Amit Meller was among nine researchers chosen for the NIH's National Human Genome Research Institute "$1,000 Genome" grants nationally. Meller and co-principal investigator Zhiping Weng, also a BU biomedical engineer, won $2.2 million over the next three years for their research, in addition to some $600,000 Meller has already received from NIH for this work.

Meller is using novel methods to decode the sequence of bases on a DNA strand at the molecular level. Using beams of electrons, Meller punches tiny holes in thin silicon films, then pulls strands of DNA through these "nanopores" using an electric current. Each base is identified by a florescent marker attached to it, which allows the researchers to record the sequence of bases as the strand emerges from the nanopore. Meller has devised a system of lasers and highly sensitive detectors which greatly increase the process' resolution. He is the only researcher in the world using this method, which he names "Opti-Pore."

Weng's involvement centers on bioinformatics ?using computational methods to organize the large amount of data collected.

Meller said he is grateful for the grant, which validates his approach to DNA sequencing. "We are very close to a proof of principle that we can read a small number of these bases, perhaps six or eight, using this method," said Meller. "From there, it is a small step to reading tens, and later hundreds, at a time. That would produce an orders-of-magnitude reduction in the cost of sequencing individuals' DNA."

According to NIH, sequencing the 3 billion base pairs on a human genome using current technology costs about $10 million. Reducing the cos
'"/>

Source:Boston University


Page: 1 2

Related biology news :

1. University of Manchester makes made-to-measure skin and bones a reality using inkjet printers
2. New protein discovered by Hebrew University researchers
3. Next Generation Body Scanner Launched By The University Of Manchester
4. Roundup®highly lethal to amphibians, finds University of Pittsburgh researcher
5. Green catalyst destroys pesticides and munitions toxins, finds Carnegie Mellon University
6. University of Nevada, Reno research team discovers hormone that causes malaria mosquito to urinate
7. Carnegie Mellon University research reveals how cells process large genes
8. University of Delaware researchers develop cancer nanobomb
9. University of Arizona plant scientists to unravel maize genome
10. Team led by Carnegie Mellon University scientist finds first evidence of a living memory trace
11. University of Utah to help build bionic arm
Post Your Comments:
(Date:9/2/2014)... present the prestigious Parker/Gentry Award to Mr. Rhett A. ... awareness. The Parker/Gentry Award is given annually by the ... whose efforts have had a significant impact on preserving ... serve as a model to others. , Rhett Butler ... conservation news website that draws more than 2 million ...
(Date:9/2/2014)... the September issue of BioScience , Samantha ... communities in the aftermath of the 2010 Macondo ... hydrocarbon-degrading microbes to the unprecedented deepwater oil plume., ... the responses of indigenous microbial communities to a ... within cells known as ribosomal RNA and analyses ...
(Date:9/2/2014)... American Society of Human Genetics (ASHG) and the ... the National Institutes of Health, have named Elizabeth ... The Wellington School in Columbus, Ohio, the first ... begins today. , The Genetics and Education Fellowship ... their skills, experience, and network to prepare for ...
Breaking Biology News(10 mins):Changing microbial dynamics in the wake of the Macondo blowout 2ASHG and NHGRI award first genetics and education fellowship 2
... counteract the greenhouse effect, some scientists have proposed capturing the ... the gas and injecting it into the ocean. But there ... can rise toward the surface, turn into gas bubbles and ... grand scheme. Even worse, if the liquid-to-gas conversion happens suddenly, ...
... for doctors to withhold information from patients about new drugs ... week's BMJ. , New drugs may be more effective ... not be available through publicly funded health schemes. , ... to ask a patient to finance the full cost of ...
... how neurons control growth of the intricate tracery ... connect with their neighbors. Dendritic connections are the ... signaling networks that constitute the brain's circuitry. , ... researchers better understand brain development in children, as ...
Cached Biology News:Asleep in the deep: Model helps assess ocean-injection strategy for combating greenhouse effect 2Should doctors tell patients about expensive, unfunded drugs? 2How the neuron sprouts its branches 2How the neuron sprouts its branches 3
(Date:9/2/2014)... (PRWEB) September 02, 2014 Myriant ... the signage of a distribution agreement with Azelis ... now distributing Myriant’s bio-succinic acid in the Nordics, ... Ireland, targeting customers in the industrial and base ... powerhouse, Azelis offers a far-reaching chemical portfolio with ...
(Date:9/2/2014)... MONROVIA, Calif. , Sept. 2, 2014 /PRNewswire/ ... clinical-stage biopharmaceutical company developing engineered monoclonal antibodies for ... diseases, and cancer, today announced the appointment of ... clinical development and the appointment of Lloyd ... and general counsel. "Debra,s expertise ...
(Date:9/2/2014)... ON , Sept. 2, 2014 /PRNewswire/ - BIOREM Inc. (TSXV: ... totalling $2.1 million. The orders consist of three large odour ... Canada . "These orders are consistent with ... said Peter Bruijns , President and CEO. "After a ... market, we are now beginning to see sales growth. Our ...
(Date:9/2/2014)... , September 2, 2014 ... BioData,s research and lab management services  BioData, ... service, is pleased to announce the appointment of ... most recently served as VP Marketing and Business Development ... science research and clinical applications. Previously, Culot ...
Breaking Biology Technology:Myriant and Azelis Sign European Distribution Agreement for Bio-Succinic Acid 2Xencor Appoints Debra Zack, M.D., Ph.D., Vice President, Clinical Development and Lloyd Rowland, Senior Vice President, Chief Compliance Officer and General Counsel 2Xencor Appoints Debra Zack, M.D., Ph.D., Vice President, Clinical Development and Lloyd Rowland, Senior Vice President, Chief Compliance Officer and General Counsel 3Louis Culot Appointed as BioData's CEO 2
... VANCOUVER, March 4 /PRNewswire-FirstCall/ - OncoGenex Pharmaceuticals, Inc. (NASDAQ: ... fourth quarter and fiscal year 2008 financial results will ... the Company will host a conference call and live ... discuss the company,s financial results and provide a 2009 ...
... from finely etched lines in silicon wafers to ... of Energy,s Lawrence Berkeley National Laboratory (Berkeley Lab) ... through a molecular junctiona nanometer scale circuit element ... Their findings reveal the electrical resistance through this ...
... 3 /PRNewswire-FirstCall/ - Oncothyreon Inc. (Nasdaq: ONTY ... of innovative therapeutic products for the treatment of cancer, ... quarter and year end 2008 financial results on Monday, ... and Canadian markets. Following the release, Oncothyreon,s management expects ...
Cached Biology Technology:Researchers discover a potential on-off switch for nanoelectronics 2Researchers discover a potential on-off switch for nanoelectronics 3Researchers discover a potential on-off switch for nanoelectronics 4
... sealed isolation chamber provides a safe, ... sterile pharmaceuticals, in accord with USP-797 ... 100 (ISO 5) cleanliness conditions in ... IV rod and tilt-up front panel ...
... Protein determined by Biuret. Physical ... (NH 4 ) 2 SO ... Note: Affinity purified • Physical ... Additives: MgCl 2 1 ...
Ideal for chemical processing that requires downward flow of exhaust fumes. Powderful 1200 CFM blower draws fumes into sub-surface bonded charcoal filter for safe removal of organic vapors (final HEP...
... using mass numbers as a trigger, precisely ... performing investigation and research of natural compounds. ... and preparative operation. Switching between modes is ... This support provides a quick solution for ...
Biology Products: