Navigation Links
Boston University biomedical engineers win major grant for pursuit of the '$1,000 Genome'

Two Boston University biomedical engineers have won a major National Institutes of Health (NIH) grant to continue groundbreaking research aimed at reducing the cost of sequencing individual human genomes to about $1,000.

Boston University Associate Professor of Biomedical Engineering and Physics Amit Meller was among nine researchers chosen for the NIH's National Human Genome Research Institute "$1,000 Genome" grants nationally. Meller and co-principal investigator Zhiping Weng, also a BU biomedical engineer, won $2.2 million over the next three years for their research, in addition to some $600,000 Meller has already received from NIH for this work.

Meller is using novel methods to decode the sequence of bases on a DNA strand at the molecular level. Using beams of electrons, Meller punches tiny holes in thin silicon films, then pulls strands of DNA through these "nanopores" using an electric current. Each base is identified by a florescent marker attached to it, which allows the researchers to record the sequence of bases as the strand emerges from the nanopore. Meller has devised a system of lasers and highly sensitive detectors which greatly increase the process' resolution. He is the only researcher in the world using this method, which he names "Opti-Pore."

Weng's involvement centers on bioinformatics ?using computational methods to organize the large amount of data collected.

Meller said he is grateful for the grant, which validates his approach to DNA sequencing. "We are very close to a proof of principle that we can read a small number of these bases, perhaps six or eight, using this method," said Meller. "From there, it is a small step to reading tens, and later hundreds, at a time. That would produce an orders-of-magnitude reduction in the cost of sequencing individuals' DNA."

According to NIH, sequencing the 3 billion base pairs on a human genome using current technology costs about $10 million. Reducing the cos
'"/>

Source:Boston University


Page: 1 2

Related biology news :

1. University of Manchester makes made-to-measure skin and bones a reality using inkjet printers
2. New protein discovered by Hebrew University researchers
3. Next Generation Body Scanner Launched By The University Of Manchester
4. Roundup®highly lethal to amphibians, finds University of Pittsburgh researcher
5. Green catalyst destroys pesticides and munitions toxins, finds Carnegie Mellon University
6. University of Nevada, Reno research team discovers hormone that causes malaria mosquito to urinate
7. Carnegie Mellon University research reveals how cells process large genes
8. University of Delaware researchers develop cancer nanobomb
9. University of Arizona plant scientists to unravel maize genome
10. Team led by Carnegie Mellon University scientist finds first evidence of a living memory trace
11. University of Utah to help build bionic arm
Post Your Comments:
(Date:7/11/2014)... including scientists from the Max Planck Institute for Medical ... step in understanding photosynthesis, the process by which the ... its atmosphere and which is therefore crucial for all ... researchers report the first direct visualization of a crucial ... which a specific protein complex, photosystem II, splits water ...
(Date:7/11/2014)... risk of kidney injury related to the use of ... of HES molecules, according to a report in ... Anesthesia Research Society (IARS). , The "total mass of ... cultured human renal proximal tubule cells (PTCs), concludes the ... University Hospital Wrzburg, Austria. Other factorssuch as differences ...
(Date:7/11/2014)... is evidence that under the normal circumstances, ... development, maintain neuronal environment, and exhibit therapeutic ... neurodegenerative disease. Previous studies have found that ... after chemical induction have reduced viability, which ... Prof. Xiaodong Yuan, Kailuan General Hospital, Hebei ...
Breaking Biology News(10 mins):A first direct glimpse of photosynthesis in action 2In lab studies, hydroxyethyl starch has direct harmful effects on kidney cells 2
... paper published in the January issue of the journal ... including William A. Masters, a professor at the Friedman School ... new approach to monitoring the relationship between nutrition and child ... of surveys compiled over 20 years, changes in the number ...
... January 31, 2011 A scientist from The Scripps Research Institute ... in preventing blood clot formation. The molecule could become a ... blood clotting diseases such as Hemophilia A. The findings, ... Mosnier, were published in a recent edition of Journal ...
... In order for medical students to ultimately provide quality patient ... teach physiology, one of the core disciplines of medicine, according ... Journal of the American College of Radiology ( www.jacr.org ... systems. "It is vital that medical schools provide ...
Cached Biology News:New approach suggested for monitoring child health in developing countries 2Scripps Research scientist discovers natural molecule indirectly prevents stable clot formation 2Scripps Research scientist discovers natural molecule indirectly prevents stable clot formation 3
(Date:7/11/2014)... July 11, 2014 /CNW/ - Sunovion Pharmaceuticals Canada Inc. ... (eslicarbazepine acetate) for use as a once-daily adjunctive ... with epilepsy who are not satisfactorily controlled with conventional ... in patients under 18 years of age. ... disorders and according to Epilepsy Canada, it affects 0.6% ...
(Date:7/11/2014)... AZ (PRWEB) July 11, 2014 ... device company specializing in the soft tissue reconstruction ... All-Suture Anchor System for surgeries involving the shoulder ... fixation through a novel, inserter-controlled deployment method. The ... to partial deployment, anchor pull-out, or anchor displacement ...
(Date:7/10/2014)... 10, 2014 Product and process ... low abundance and are often “lost in the ... , Join presenters Dr. Rowel Tobias, Senior Scientist, ... Anders, Head of Quality at Nanotherapeutics, Inc., to ... can speed detection and quantitation while achieving the ...
(Date:7/10/2014)... Understanding the need for better quality ... the gap that currently exists in this area, ChanTest ... portfolio of validated ion channel and GPCR cell lines. ... as ion channels control many critical physiological functions throughout ... the potential to treat a variety of human diseases. ...
Breaking Biology Technology:Sunovion Pharmaceuticals Canada Inc. Announces Health Canada Approval of APTIOM(TM) (eslicarbazepine acetate) as a Once-Daily Adjunctive Treatment for Partial-Onset Seizures in Patients with Epilepsy 2Sunovion Pharmaceuticals Canada Inc. Announces Health Canada Approval of APTIOM(TM) (eslicarbazepine acetate) as a Once-Daily Adjunctive Treatment for Partial-Onset Seizures in Patients with Epilepsy 3Sunovion Pharmaceuticals Canada Inc. Announces Health Canada Approval of APTIOM(TM) (eslicarbazepine acetate) as a Once-Daily Adjunctive Treatment for Partial-Onset Seizures in Patients with Epilepsy 4Cayenne Medical Launches SureLock™ All-Suture Anchor System for Shoulder and Extremity Surgery 2Cayenne Medical Launches SureLock™ All-Suture Anchor System for Shoulder and Extremity Surgery 3Novel Ms Techniques Speed Detection of Biopharmaceutical Product and Process Impurities, New Webinar Hosted by Xtalks 2Leader in Ion Channel Research Announces Newly Validated and Re-Engineered Cells 2Leader in Ion Channel Research Announces Newly Validated and Re-Engineered Cells 3
... product ideas to market, RESEARCH TRIANGLE PARK, N.C., ... to $1 million in loans under,a program unveiled this ... loans are part of an expanded program funded by ... give early-stage,companies a boost before they become competitive for ...
... Nargis, a category 3 tropical storm that struck the low-lying and ... Agriculture Service (FAS) of the U.S. Department of Agriculture (USDA) began ... damaged agricultural areas to accompany its commodity intelligence reports. , ... ...
... July 9 Brinks Hofer Gilson & Lione, one of ... opening,of a new office in the Raleigh/Durham, North Carolina area ... T. Elliott, who will be,based in the Raleigh office. Mr. ... the firm as partners. The office will officially,be open for ...
Cached Biology Technology:N.C. Biotech Center Launches Larger Loans 2Myanmar's Cyclone-Damaged Rice Production Regions Monitored with GIS 2Myanmar's Cyclone-Damaged Rice Production Regions Monitored with GIS 3Brinks Hofer Gilson & Lione Expands to High-Tech Raleigh/Durham Area; Adds Accomplished Patent Attorneys to Its New Office 2Brinks Hofer Gilson & Lione Expands to High-Tech Raleigh/Durham Area; Adds Accomplished Patent Attorneys to Its New Office 3
... deuterium atoms at the 9, 10, 12, and ... an internal standard for the quantification of 13(S)-HODE ... by incubation of linoleic acid with plant and ... the adhesion of tumor cells to the endothelium ...
...
...
DryStrip aligners, 4. Category: Electrophoresis Systems & Standards & Reagents, IEF & SDS-PAGE & 2-D Electrophoresis, Multiphor II Kits & Components and Accessories....
Biology Products: