Navigation Links
Boosting newborns' immune responses

Newborn babies have immature immune systems, making them highly vulnerable to severe infections and unable to mount an effective immune response to most vaccines, thereby frustrating efforts to protect them. Researchers at Children's Hospital Boston now believe they have found a way to enhance the immune system at birth and boost newborns' vaccine responses.

In a study published in the online edition of the journal Blood on April 25, Ofer Levy, MD, PhD and colleagues in Children's Division of Infectious Diseases show that the newborn immune system functions differently than that of adults, but that one portion of the immune response is fully functional and can be harnessed to boost immunity in these tiny infants, possibly making infections like respiratory syncytial virus, pneumococcus, pertussis, HIV and rotavirus much less of a threat.

For about a decade it's been known that people's first line of defense against infection is a group of receptors known as Toll-like receptors (TLRs) on the surface of certain white blood cells. Functioning like an early radar system, TLRs detect the presence of invading bacteria and viruses and trigger production of "danger signals" ?proteins known as cytokines that trigger other immune cells to mount a defense against the infection. People have 10 different kinds of TLRs, and Levy's team decided to examine how well they function in newborns by studying white blood cells from their cord blood.

"We found that when most Toll-like receptors are stimulated, newborns' immune responses are very impaired," Levy says. "But there was one important exception."

Levy's team, including Harvard graduate Eugenie Suter and senior author Michael Wessels, MD, showed that one TLR, known as TLR8, triggered a robust immune response in a group of white blood cells (called antigen-presenting cells) that is crucial for vaccine responses. When TLR8 was stimulated by various agents that mimic viral antigens, the cells produc
'"/>

Source:Children's Hospital Boston


Page: 1 2 3

Related biology news :

1. Boosting HIV screening can increase survival and is cost effective
2. Boosting The BCG Vaccine To Beat Tuberculosis
3. Boosting brain power -- with chocolate
4. Fox Chase Cancer Center scientists identify immune-system mutation
5. Genetically modified natural killer immune cells attack, kill leukemia cells
6. Studies reveal methods viruses use to sidestep immune system
7. Jumping gene helps explain immune systems abilities
8. Scientists solve structure of key protein in innate immune response
9. Rats infected as newborns grew up vulnerable to memory problems during an immune challenge
10. NYU study reveals how brains immune system fights viral encephalitis
11. Chemists identify immune system mechanism for methamphetamine binges
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Boosting newborns immune responses

(Date:8/10/2015)... Germany , August 10, 2015 ... in Eye Tracking Technology for more than two decades, ... Platform for integration into all consumer display formats. The ... seamless integration of eye tracking into consumer tablets, laptops, ... reality smart glasses. Omnivision,s leading sensor technology contributes to ...
(Date:8/5/2015)... , August 5, 2015 ... & Access Management Market by Software, Services, Vertical (BFSI, Airport, ... & Geography - Global Forecast to 2020", published by ... Management Market globally into various segments. The global PIAM ... 2014 to $546.2 Million by 2019, at a CAGR ...
(Date:8/3/2015)... SAN JOSE, Calif. , Aug. 3, 2015 /PRNewswire/ ... developer of human interface solutions, today announced that members ... investment community at the Pacific Crest Global Technology Leadership ... Mountain Time. The conference will be held at the ... The presentation may include forward-looking information. ...
Breaking Biology News(10 mins):SMI Completes OEM Eye Tracking Platform to Cover All Consumer Displays 2SMI Completes OEM Eye Tracking Platform to Cover All Consumer Displays 3Physical Identity and Access Management Market Worth $546.2 Million by 2019 2Physical Identity and Access Management Market Worth $546.2 Million by 2019 3Physical Identity and Access Management Market Worth $546.2 Million by 2019 4
... Stem cell research promises remedies to many devastating diseases ... disease to paralysis. Totipotent embryonic stem cells have great ... cells that can be used to restore malfunctioning or ... shown that pluripotent stem cells derived from adult bone ...
... as much at home walking four-legged on the ground as ... years ago with the same rare ability, a new study ... the agile walking and climbing skills of the lesser short-tailed ... absence of any ground-dwelling mammal competitors or predators, says an ...
... an enzyme in the brains of newborns suffering from ... brain damage that is a leading cause of cerebral ... Cincinnati Children,s Hospital Medical Center. Reporting their results ... show blocking the brain enzyme, tissue-type plasminogen activator (tPA), ...
Cached Biology News:Stem cell research: From molecular physiology to therapeutic applications 2Stem cell research: From molecular physiology to therapeutic applications 3Stem cell research: From molecular physiology to therapeutic applications 4Bizarre walking bat has ancient heritage 2Experimental treatment halts hypoxic-ischemic brain injury in newborns 2Experimental treatment halts hypoxic-ischemic brain injury in newborns 3
(Date:8/27/2015)... Poway, CA (PRWEB) , ... August 27, 2015 ... ... a unique opportunity for venture capital funds, investment firms and animal health companies ... the Forum have raised $160 million. Several have also received licensing agreements or ...
(Date:8/27/2015)... 2015  Asterias Biotherapeutics, Inc. (NYSE MKT: AST), a ... medicine, today announced that executives from the company will ... September.  , Pedro Lichtinger , ... 17th Annual Global Investment Conference on Wednesday, September 10, ... Hotel in New York City . ...
(Date:8/27/2015)... ... August 27, 2015 , ... METTLER TOLEDO's web-based EasyFinder™ ... product choices to a manageable shortlist of bench and floor scales and terminals. ... fit best with the customer’s industry and application. , Side-by-side product comparisons ...
(Date:8/26/2015)... N.J. , Aug. 26, 2015  Roka Bioscience, ... focused on providing advanced testing solutions for the detection ... CEO will present at the Sidoti & Company Emerging ... conference will be held at the New York Marriott ... presentation will be available through the investor relations section ...
Breaking Biology Technology:VetStem Biopharma, Inc. Among Seventeen Companies Selected to Present at the KC Animal Health Investment Forum on September 1st 2015 2VetStem Biopharma, Inc. Among Seventeen Companies Selected to Present at the KC Animal Health Investment Forum on September 1st 2015 3Asterias Biotherapeutics to Present at Upcoming Investor Conferences 2METTLER TOLEDO Updates Online Scale Selection Tool 2
... , , , ... a private biotechnology company discovering and developing innovative treatments for ... the department of physiology at the University of California, San ... has joined Solace,s scientific advisory board. , , ...
... , FLAGSTAFF, Ariz., July 24 ... New Zealand, Great Britain, Myanmar, the Philippines and Indonesia are meeting ... Woodlands Hotel to share research findings that will determine the future ... , On Sunday morning, Mayor Sara Presler will welcome ...
... , MADISON, N.J., July 24 Quest Diagnostics Incorporated ... testing, information and services, today announced that the U.S. Food and ... company,s Focus Diagnostics business for its test for detecting the 2009 ... A virus initially referred to as the swine flu virus. ...
Cached Biology Technology:Solace Pharmaceuticals Appoints Professor David Julius, Renowned Pain Physiologist, to Scientific Advisory Board 2Solace Pharmaceuticals Appoints Professor David Julius, Renowned Pain Physiologist, to Scientific Advisory Board 3World Renowned Scientists Gather to Share Latest Information on Answer to Wildlife Reproductive Fertility Control 2FDA Grants First Authorization of a Commercial 2009 H1N1 Flu Test for use During Pandemic Flu Emergency to Quest Diagnostics' Focus Diagnostics Business 2FDA Grants First Authorization of a Commercial 2009 H1N1 Flu Test for use During Pandemic Flu Emergency to Quest Diagnostics' Focus Diagnostics Business 3FDA Grants First Authorization of a Commercial 2009 H1N1 Flu Test for use During Pandemic Flu Emergency to Quest Diagnostics' Focus Diagnostics Business 4FDA Grants First Authorization of a Commercial 2009 H1N1 Flu Test for use During Pandemic Flu Emergency to Quest Diagnostics' Focus Diagnostics Business 5
ANTI PIG LDH H4...
... Fiberboard boxes are ideal for use in refrigerators, freezers, ... racks. Four vibrant colors allow for color coding to ... liquid nitrogen drainage or promote cool air circulation. Supplied ... holds 100 tubes. Box dimensions: 13 x ...
Recombinant Rhesus Monkey IFN-Alpha...
RABBIT ANTI AMPHOTERIN...
Biology Products: