Navigation Links
Bones hold the key to blood renewal

>
Department, which included Dr. Orit Kollet and colleagues, found that the bone-dismantling osteoclasts are instrumental in releasing hematopoietic stem cells into the bloodstream. As they wear away the bone, they allow the stem cells out of the niches and into the bloodstream. Although some hematopoietic stem cells can always be found circulating in the blood, when there is bleeding or inflammation in the body, more stem cells are needed to deal with the situation and restore balance. The team's study showed that the bone marrow response to the body's call for help involves stepping up production of osteoclasts, putting machinery that normally operates at a leisurely pace into high gear. The osteoclasts not only clear away bone, they also break up 'nurturing' substances in the niche that attract and hold the stem cells to that spot, thus allowing more stem cells into the bloodstream.

The team carried out their research on mice, including some developed in the lab of Prof. Ari Elson of the Molecular Genetics Department, in which the osteoclasts carried a mutation that rendered them only partially functional in the young females. They found abnormally low stem cell levels in the blood of these mice even when they tried to encourage their mobilization, giving them solid evidence of the connection. In normal mice, using a chemical compound that stimulates osteoclast formation, they were able to boost osteoclast levels and thus manage the release of stem cells into the blood in a variety of stress situations. This finding may have implications for bone marrow transplant techniques: The drugs given today to donors to increase the supply of stem cells in their bloodstream before they are harvested for transplantation cause the release of many other mature cells as well. Injecting the osteoclast-promoting substance into the mice, on the other hand, resulted in an increase mainly in stem cell release. These findings add a new dimension to our understanding of
'"/>

Source:American Committee for the Weizmann Institute of Science


Page: 1 2 3

Related biology news :

1. Bones from blood: Scientists aim to break new ground on fractures
2. Bones at the nanoscale
3. Bones in motion: Brown scientists to create new 3-D X-ray system
4. White blood cell waste disposal system plays critical regulatory role
5. Epstein-Barr virus protein crucial to its role in blood cancers
6. New insight into regulation of blood stem cells
7. Nano-bumps could help repair clogged blood vessels
8. First technology to remove prions that cause vCJD from blood launched
9. Breakthrough isolating embryo-quality stem cells from blood
10. Thai spice helps cut blood sugar swings
11. Study shows humans have ability to track odors, much like bloodhounds
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Bones hold the key blood renewal

(Date:7/23/2014)... personalized cancer medicine, (the WIN consortium), recently announced that ... University will be one of its six new ... in the Tri-State Area. The goal of WIN is ... the patient by forging collaborations between partners in academia, ... WIN consortium means Jefferson cancer patients will have access ...
(Date:7/23/2014)... local and national governments struggle to deal with ever-growing ... refining the picture of just how much there is ... ACS journal Environmental Science & Technology , their ... developed countries discard floods into just seven developing countries ... who live there. , Knut Breivik and colleagues note ...
(Date:7/23/2014)... NY -- The potential for clinical use of ... therapeutic strategies has previously been hindered by the ... of tumors. The ability to use etoposide treatment ... treatment of heart disease, specifically acute myocardial infarction, ... Cells and Development , a peer-reviewed journal from ...
Breaking Biology News(10 mins):New partnership brings more personalized cancer treatment to Philadelphia 2
... Research!America Chair John Edward Porter says federal budget negotiations ... "The rancorous budget debates between the White ... in science and innovation is tenuous at best if spending ... the House and Senate would put funding for medical research ...
... tend to give their developing embryos short shrift, but ... the babies once they,re born, according to a study ... Stress changes the way animals allocate energy. ... that help the body to access stored energy. But ...
... remember faces and voices of several known individuals. Similarly, ... of known individuals after a number of years. Markus ... Biology of the University of Vienna show in their ... ravens differentiate individuals based on familiarity. Additionally, they discovered ...
Cached Biology News:Lizard moms may prepare their babies for a stressful world 2
(Date:7/23/2014)... (PRWEB) July 23, 2014 DuPont Pioneer ... business as vice president of Agricultural Biotechnology (ABT), effective ... where he served most recently as president, chief executive ... and business leadership in the seed and crop protection ... Paul E. Schickler , president of DuPont Pioneer. ...
(Date:7/23/2014)... 23, 2014  GrowBLOX Sciences, Inc. (OTCQB: GBLX), a medical ... filing for two medical marijuana dispensary locations in ... to the Clark County, Nevada dispensary ... as previously announced.  GrowBLOX Sciences, CEO Craig ... new applications for dispensaries in the City of ...
(Date:7/23/2014)... Plainsboro, N.J. (PRWEB) July 23, 2014 ... Lineberger Comprehensive Cancer Center has joined its Strategic ... the Strategic Alliance Partnership program, UNC Lineberger will ... team to raise awareness of its cutting-edge research ... Experts from UNC Lineberger will work with OncLive ...
(Date:7/22/2014)... NJ (PR Web) July 21, 2014 (PRWEB) July ... Center for Biomaterials, at Rutgers University. , ... information and ideas across the full spectrum of ... on selected research and development topics that represent ... Activities have been programmed to:, ...
Breaking Biology Technology:DuPont Pioneer Names Neal Gutterson to Lead Agricultural Biotechnology 2DuPont Pioneer Names Neal Gutterson to Lead Agricultural Biotechnology 3GrowBLOX Sciences, Inc. Files for Two Additional Medical Marijuana Dispensaries in Las Vegas 2GrowBLOX Sciences, Inc. Files for Two Additional Medical Marijuana Dispensaries in Las Vegas 3OncLive Expands Its Strategic Alliance Partnership Program With the Addition of UNC Lineberger Comprehensive Cancer Center 2OncLive Expands Its Strategic Alliance Partnership Program With the Addition of UNC Lineberger Comprehensive Cancer Center 3The 2014 NJ Symposium on Biomaterials Science Earns Society for Biomaterials Endorsement 2
... Detailed data from,a randomized Phase 2 study with PROSTVAC(TM) ... presentation was made by Philip Kantoff,MD, Professor of Medicine, ... also the principal investigator of the study. , ... that were reported,in October 2008. In the Phase 2 prospective ...
... (Nasdaq: PCYC ) today announced that it filed ... Exchange Commission (the "SEC") for a rights offering to its ... the distribution of non-transferable subscription rights to purchase shares of ... a subscription price to be determined. Assuming the rights ...
... Technology with High Definition MS (HDMS) Defines New Levels ... Opens New Frontiers in Scientific Discovery , , ... WAT ) announced today the introduction of a powerful ... System. Taking qualitative and quantitative quadrupole time-of-flight mass spectrometry ...
Cached Biology Technology:PROSTVAC(TM) Data Presented at the ASCO Meeting Demonstrates the Potential for Significant Increases in Life Expectancy in Late-Stage Prostate Cancer 2PROSTVAC(TM) Data Presented at the ASCO Meeting Demonstrates the Potential for Significant Increases in Life Expectancy in Late-Stage Prostate Cancer 3Pharmacyclics Files Registration Statement for Rights Offering 2Pharmacyclics Files Registration Statement for Rights Offering 3Pharmacyclics Files Registration Statement for Rights Offering 4Waters Introduces New SYNAPT G2 with Greater Power, Versatility and Speed Than Any Other High-End Mass Spectrometer 2Waters Introduces New SYNAPT G2 with Greater Power, Versatility and Speed Than Any Other High-End Mass Spectrometer 3Waters Introduces New SYNAPT G2 with Greater Power, Versatility and Speed Than Any Other High-End Mass Spectrometer 4Waters Introduces New SYNAPT G2 with Greater Power, Versatility and Speed Than Any Other High-End Mass Spectrometer 5Waters Introduces New SYNAPT G2 with Greater Power, Versatility and Speed Than Any Other High-End Mass Spectrometer 6
PC based system for advanced chemifluorescent, chemiluminescent, fluorescent and colorimetric, microarray and microscope imaging and analysis....
PC based system for superior chemifluorescent, chemiluminescent, fluorescent and colorimetric, microarray and microscope imaging and analysis....
Rabbit Polyclonal antibody to Perilipin Applications: This antibody is useful for Western blot anlaysis where a band at ~60 kDa is seen....
Conveniently document gels, films and membranes with a high quality thermal printer. , Compact, footprint printer , Supplies 256 gray scale for high resolution, archive-quality thermal film prints...
Biology Products: