Navigation Links
Bones hold the key to blood renewal

Though we think of them as solid and permanent, our bones are actually constantly being rebuilt throughout our lives. A team of scientists at the Weizmann Institute of Science has now revealed how cells that work at remodeling the bones play a direct part in the ongoing renewal of another system ?the blood. Their findings, which may lead to future improvements in bone marrow transplantation and a better understanding of diseases involving bone or blood renewal, were published in the June issue of Nature Medicine.

Bones are really two systems in one. The cavities inside bones are filled with spongy bone marrow, in which stem cells divide and their daughter cells differentiate into all kinds of blood cells, including large numbers of immune cells for the body's defense. The hematopoietic (literally, blood-creating) stem cells, which can give rise to any kind of blood cell, reside in special 'stem cell niches' nestled in the bones' inner walls. Inside these sheltered nurseries, the stem cells remain undifferentiated; with the help of other nearby cells, they hang on to their juvenile qualities. Only when they leave the niches do they morph into specialized blood cells, possibly becoming immune cells for fighting infection or cells for blood clotting and healing after injury. They can even respond to calls for help from organs such as the liver, migrating through the bloodstream to assist in repairing damage.

The inner walls of the bones are also sites of intensive reconstruction. While one type of cell, the osteoblast, is busy building bone, its partner, the osteoclast, breaks it down and reassimilates the material. Osteoclasts are formed when several cells (which themselves originate from hematopoietic stem cells) fuse together at a signal from the osteoblasts, and the two work together in a sort of 'urban renewal' scheme to keep the bones healthy and strong.

The Weizmann Institute team headed by Prof. Tsvee Lapidot of the Immunology'"/>

Source:American Committee for the Weizmann Institute of Science


Page: 1 2 3

Related biology news :

1. Bones from blood: Scientists aim to break new ground on fractures
2. Bones at the nanoscale
3. Bones in motion: Brown scientists to create new 3-D X-ray system
4. White blood cell waste disposal system plays critical regulatory role
5. Epstein-Barr virus protein crucial to its role in blood cancers
6. New insight into regulation of blood stem cells
7. Nano-bumps could help repair clogged blood vessels
8. First technology to remove prions that cause vCJD from blood launched
9. Breakthrough isolating embryo-quality stem cells from blood
10. Thai spice helps cut blood sugar swings
11. Study shows humans have ability to track odors, much like bloodhounds
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Bones hold the key blood renewal

(Date:7/13/2014)... New research raises the prospect of more effective ... muscle occurring in about half of all cancer patients, ... Dana-Farber Cancer Institute. , Many strategies have been tried ... that patients can,t endure potentially life-saving treatments, but none ... July 13 advanced online edition of Nature , ...
(Date:7/11/2014)... 2014--Researchers at the Department of Energy,s Oak Ridge ... presented by R&D Magazine in recognition of the ... recognize the tremendous value of our National Labs," ... development at the National Labs continues to help ... the scientific and technological innovations necessary to remain ...
(Date:7/11/2014)... of Entiat on Tuesday, July 8, 2014. Despite the ... over 1,000 acres by evening. Three outbuildings were damaged. ... the Washington Department of Natural Resources. The fire ... fire control strategies and tactics. Other cooperators include the ... Resources, (WA DNR), Bureau of Land Management, Chelan County ...
Breaking Biology News(10 mins):Antibody halts cancer-related wasting condition 2Antibody halts cancer-related wasting condition 3ORNL wins eight R&D 100s 2ORNL wins eight R&D 100s 3ORNL wins eight R&D 100s 4
... New findings from Van Andel Research Institute (VARI) scientists ... and other stresses in harsh environments to combat global food ... in Nature last year that were named among ... "I think that the work established the methodologies and ...
... women in the US, the association between the consumption of ... diabetes mellitus (late onset diabetes) was studied for 12 years. ... but the regular moderate intake of both caffeinated coffee and ... diabetes significantly. This paper is particularly important ...
... Sebelius at the U.S. Department of Health and Human ... specific challenges to proposed modifications to HIPAA Privacy and ... its membership of 4,000 informatics professionals, detail key issues ... (NPRM) on HIPAA modifications, along with suggestions for models ...
Cached Biology News:New VARI findings next step to growing drought-resistant plants 2AMIA cites concerns about proposed HIPAA modifications 2AMIA cites concerns about proposed HIPAA modifications 3AMIA cites concerns about proposed HIPAA modifications 4
(Date:7/12/2014)... July 12, 2014 This ... reagents used in the life science industry. ... life science reagents market towards remarkable growth. ... and providers of life science reagents. , ... http://www.transparencymarketresearch.com/life-sciences-reagents-analytical-reagents.html . , The global life ...
(Date:7/11/2014)... Research ( http://www.bccresearch.com ) reveals in its new report, ... MARKETS , the global market for digital polymerase chain ... This is estimated to grow to $490 billion in ... of 28.6%. , New digital PCR technology has created ... broader PCR field. The opportunities presented by this technology ...
(Date:7/11/2014)... Scottsdale, AZ (PRWEB) July 11, 2014 ... medicine device company specializing in the soft tissue ... SureLock All-Suture Anchor System for surgeries involving the ... predictable fixation through a novel, inserter-controlled deployment method. ... lead to partial deployment, anchor pull-out, or anchor ...
(Date:7/10/2014)... Understanding the need for better quality and ... gap that currently exists in this area, ChanTest has ... of validated ion channel and GPCR cell lines. ... ion channels control many critical physiological functions throughout the ... potential to treat a variety of human diseases. ...
Breaking Biology Technology:Transparency Market Research: Life Science Reagents Market- PCR Reagent Kits, Cell and Tissue Culture, Flow Cytometry, Electrophoresis and Chromatography 2Transparency Market Research: Life Science Reagents Market- PCR Reagent Kits, Cell and Tissue Culture, Flow Cytometry, Electrophoresis and Chromatography 3Global Market for Digital Polymerase Chain Reaction Technology to Reach $490 Billion by 2018; Equipment Sector Accounts for the Fastest Growing Segment With 33% CAGR 2Global Market for Digital Polymerase Chain Reaction Technology to Reach $490 Billion by 2018; Equipment Sector Accounts for the Fastest Growing Segment With 33% CAGR 3Cayenne Medical Launches SureLock™ All-Suture Anchor System for Shoulder and Extremity Surgery 2Cayenne Medical Launches SureLock™ All-Suture Anchor System for Shoulder and Extremity Surgery 3Leader in Ion Channel Research Announces Newly Validated and Re-Engineered Cells 2Leader in Ion Channel Research Announces Newly Validated and Re-Engineered Cells 3
... Thieme's new book, Islands in the Clickstream is ... WTN will be reprinting excerpts from selected chapters of Islands ... week features an excerpt from chapter four, Hacking and the ... of Thieme's writings. , , Hactivism and Soul Power ...
... this summer, we looked at venture capital funding in ... reached about $5 billion in investments in small companies. ... $5.4 billion invested during the fourth quarter of 2003, ... results for the second quarter of 2004 were a ...
... Source: Office of U.S. Rep. Jane Harman (D-Redondo Beach, Calif.) ... Republican? , ,As silly as that question is, it appears ... lamentable wedge issues of the 2004 presidential campaign. Both political ... a back seat to stem cell politics. , ,If you ...
Cached Biology Technology:Islands in the Clickstream: Hactivism and Soul Power 2Islands in the Clickstream: Hactivism and Soul Power 3Islands in the Clickstream: Hactivism and Soul Power 4Midwest life science companies capture 3% of VC investments in Q.2 2Dividing stem cells along partisan lines isnt a good experiment 2Dividing stem cells along partisan lines isnt a good experiment 3
Protein Kinase D2 Immunogen: Human protein kinase D2. Storage: -20 C, Avoid Freeze/Thaw Cycles...
...
... Upright Freezer Inventory Storage Racks for ... available to fit all makes and ... Made of high quality stainless ... high fiberboard, stainless steel or plastic ...
Many mammalian cell types and experimental situations create challenges for standard transfection experiments. The ViraPower Lentiviral Expression System overcomes these challenges with efficient vir...
Biology Products: