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Bone marrow stem cells may heal hearts even years after heart attacks

Valhalla, New York, who was not connected with this study, called the results "extremely interesting."

"The data are strongly suggestive. The data are very interesting. However, let's do a double-blind clinical trial and then we'll know for sure where we stand at this stage."

Dr. Anversa said the field of cardiac regeneration is moving fast, and he expects that ultimately it will change heart attack treatment.

Reida El Oakley, F.R.C.S., M.D., from King Fahd Medical City in Riyadh, Saudi Arabia and the National University of Singapore, who also was not connected with this study, said that in addition to confirming the safety of this type of stem cell infusion, the results help add evidence that the treatment may provide meaningful benefits to patients.

"Strauer et al. provide this indirect evidence of muscle regeneration using a simple technique to isolate mononuclear cells from the patient's own bone marrow, then transplanting these cells through the coronary artery feeding the damaged section of the heart muscle," Dr. El Oakley said. "The success of this approach will grow with time, yet more research is required to identify the ideal route of implantation, and the type of cell transplantation that is most efficient for regenerating damaged myocardium."

Roberto Bolli, M.D., F.A.C.C., from the University of Louisville in Louisville, Kentucky, who co-authored an editorial appearing in the journal, wrote that a "veritable revolution" is underway to overthrow the belief that heart muscle was incapable of regeneration. He said that previous studies showed benefits from injecting stem cells directly into damaged heart muscle or performing intracoronary infusions of stem cell into affected coronary arteries soon after a heart attack.

"The importance of the present study is that it shows that intracoronary delivery of bone marrow cells improves function and flow in patients with old myocardial infarction. This widens dramati
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Source:American College of Cardiology


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