Navigation Links
Bone marrow may restore cells lost in vision diseases

lium can become damaged with age," said Jeffrey Harris, a graduate student in the department of molecular cell biology in UF's College of Medicine and first author of the paper. "Factors like smoking and diet also come into play. The problem is without these cells, the rods and cones - our primary cells for vision - die. If we can regenerate the retinal pigment epithelium, it could make a big difference in our visual health."

Scientists were able to detect that RPE cells indeed appear to be naturally replenished in the test animals by transplanting bone marrow cells from normal male mice into albino females with two different types of acute RPE injury.

Bone marrow contains stem cells, which have the extraordinary abilities to home in on injuries and possibly regenerate other cell types in the body. In this case, the cells were transplanted to confirm that bone marrow does regenerate the injured RPE. It was easier to track male, pigment-producing cells in female, albino recipients, Harris said.

Chemical and microscopic analysis showed the cells that traveled to the injury site and transformed into RPE indeed had male genetic characteristics. Furthermore, these cells were capable of producing pigment - a colorful indication that the RPE could only have arisen from the donor bone marrow stem cells.

"We did not use a direct model of age-related macular degeneration," Scott said. "But we now know that when RPE is injured, it can be replaced in certain situations. It gives us growth factors, cell pathways and other different places to look at to find reasons why the disease is occurring."

Researchers want to discover ways to mobilize an elderly patient's own cells to travel to the injury site to make repairs.

"The dogma has been that we're born with a fixed amount of RPE, but there is growing evidence retinal progenitor cells exist in the adult," said Lawrence Rizzolo, Ph.D., a Yale University associate professor of anatomy
'"/>

Source:University of Florida


Page: 1 2 3

Related biology news :

1. Stem cells in bone marrow replenish mouse ovaries
2. Malfunctioning bone marrow cells sabotage nerve cells in diabetes
3. Bone marrow stem cells may heal hearts even years after heart attacks
4. New research demonstrates bone-marrow derived stem cells can reverse genetic kidney disease
5. Bone marrow cells can become functional gut lining cells
6. Healing the heart with bone marrow cells
7. Leukemic cells find safe haven in bone marrow
8. Early-stage sperm cells created from human bone marrow
9. New cell transplantation technique restores insulin production in diabetics
10. Cyberkinetics, Case to develop system to help restore extremity function
11. UF scientists restore sight to chickens with blinding disease
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Bone marrow may restore cells lost vision diseases

(Date:9/15/2014)... When this week,s print issue of the journal ... up from New Mexico, Montana and even the Netherlands, ... more and more the norm in these connected times. ... it will produce innovations in biology, medicine, biotechnology and ... this scientist talked with that one, that one knew ...
(Date:9/15/2014)... Sonja Schmid, an assistant professor in the Department of ... Liberal Arts and Human Sciences at Virginia Tech, has ... (CAREER) Award to study the prospects and problems of ... catastrophic failure of Japan,s Fukushima I Nuclear Power Plant ... the scientific community viewed nuclear emergencies, Schmid said. Three ...
(Date:9/15/2014)... wild, domesticated, and domesticated-wild hybridized populations of ... that within 5 to 11 generations, selection ... populations that hybridized with domesticated populations. , ... evidence that natural selection, over time, removes ... as a result of increased genetic diversity. ...
Breaking Biology News(10 mins):Collaboration drives achievement in protein structure research 2'Nuclear disasters don't respect national boundaries' 2
... to local climates -- and potentially to climate change -- may ... to new research published in Science by UBC evolutionary ... resistance to local pests -- that has helped purple loosestrife to ... species to rapidly adapt to local climate has not generally been ...
... been invading Europe,s rivers and lakes for several decades, but ... and problematic, like so many other invaders - such as ... European shrimps have something to do with this? Jaimie ... and found it only existed where native shrimps were absent ...
... body of water, from a puddle or a pond to ... rocks, plants, and animals. These so-called sessile suspension feeders are ... cleaning up environmental contaminants by consuming bacteria. A study published ... Journal reveals that by actively changing the angle of ...
Cached Biology News:Adaptability to local climate helps invasive species thrive 2Predators vs. alien: European shrimps win predatory battles with an American invader 2How tiny organisms make a big impact on clean water 2
(Date:9/13/2014)... Boehringer Laboratories Inc., with a forty year history ... successful broadcast of a live surgery by St. Luke’s ... FAMBS, and Maher El Chaar, MD, FACS, FAMBS, using ... This sleeve gastrectomy surgery was performed and broadcast live ... surgeons from around the world during the 5th International ...
(Date:9/12/2014)... Sept. 12, 2014   Arthur Kay , the ... won the Postcode Lottery Green Challenge 2014. The jury, ... 500,000 ($680,000 USD) at the final in ... Kay,s company uses a patented process ... namely biodiesel and biomass pellets, used for powering buildings ...
(Date:9/12/2014)... DUBLIN , Sept. 12, 2014 ... the "Global Dry Film Photoresist Industry Report 2014" ... Global Dry Film Photoresist Industry Report 2014 is a ... the global dry film photoresist industry . ... including definitions, classifications, applications and industry chain structure. The ...
(Date:9/12/2014)... , September 12, 2014 On Thursday, ... 0.12%, the Dow Jones Industrial Average finished the day 0.12% ... up 0.09%. The gains were broad based as seven out ... 500 Health Care Sector Index ended the day at 741.83, ... last one month. Investor-Edge has initiated coverage on the following ...
Breaking Biology Technology:Boehringer Laboratories, Inc. Announces Live Surgery Using Innovative System to Calibrate Sleeve Gastrectomy 2Green Startup Bio-Bean Wins $680,000 in Postcode Lottery Green Challenge 2Green Startup Bio-Bean Wins $680,000 in Postcode Lottery Green Challenge 3Global Dry Film Photoresist Industry Report 2014 2Technical Coverage on Biotech Stocks - Exelixis, Arena Pharma, Novavax, Dendreon, and Amicus Therapeutics 2Technical Coverage on Biotech Stocks - Exelixis, Arena Pharma, Novavax, Dendreon, and Amicus Therapeutics 3Technical Coverage on Biotech Stocks - Exelixis, Arena Pharma, Novavax, Dendreon, and Amicus Therapeutics 4Technical Coverage on Biotech Stocks - Exelixis, Arena Pharma, Novavax, Dendreon, and Amicus Therapeutics 5
... A key lawmaker who often disagrees with Governor ... he saw nothing inappropriate about the governor's use of an ... stem cell companies. , ,Meanwhile, the executive order, signed Tuesday ... from the director of Pro Life Wisconsin. , ,Ted Kanavas, ...
... - The Wisconsin Department of Motor Vehicles has deployed ... out of crime. , ,Preventing mischief in the issuance of ... Alioto, a fraud prevention specialist with the DMV , ... like a Social Security card or a birth certificate, a ...
... you're not reading this column, at least not today. May ... on the planet of the contributions to society and economy ... thousands of people will take to the streets in support ... will stay home from work. Some plan to keep their ...
Cached Biology Technology:Republican sees nothing wrong with Doyle's use of executive order 2New DMV tool never forgets a face 2New DMV tool never forgets a face 3Technology and the "American" dream 2
... a simple and convenient method for the rapid, ... been optimized for use with S. cerevisiae and ... fungus species that is susceptible to yeast lytic ... spheroplasts of yeast cells that are ideal for ...
Four siRNAs targeting your gene of interest, providing gene silencing with 100% satisfaction guaranteed High knockdown potency , High specificity for minimal off-target effects , Flexible siR...
... PHD2000 syringe pump series combines Harvard Apparatuss best ... and a wide range of configuration options. A ... dimensions of syringes from all the major manufacturers. ... all the pertinent information from across the lab. ...
... Drosophila S2 cells are used for heterologous ... System (DES). The S2 cell line was ... (20-24 hours old) Drosophila melanogaster embryos ... at room temperature without CO2 and is easily ...
Biology Products: