Navigation Links
Bone marrow cells can become functional gut lining cells

Researchers report the discovery that cells used in bone marrow transplantation can develop into new cells lining the gut, according to a study by Yale School of Medicine in the Proceedings of the National Academy of Sciences.

The study showed that bone marrow derived cells can differentiate into functional gastrointestinal epithelial cells after bone marrow transplantation. Research was from the laboratory of Diane Krause, M.D., professor of Laboratory Medicine and senior author of the study, in collaboration with Marie Egan, M.D., associate professor of pediatrics, respiratory medicine, and cellular and molecular physiology.

"We demonstrated that the cells were functional by showing that they express functional chloride channels (known as CFTR, or cystic fibrosis transmembrane conductance regulator) which are necessary for fluid balance in the gut," Krause said.

The researchers used mice that do not have this chloride channel. After bone marrow transplantation from donor mice that do have the chloride channel, recipient mice had some normal chloride channel activity.

Alhough this is exciting, the levels of donor derived gut cells are currently far too low to be used as a treatment for cystic fibrosis, an inherited disease in which the organs, especially those of the pancreas, lungs, and intestines, become clogged with thick mucus.

"We hope this finding will have implications for cystic fibrosis, but this is a first step and there are many, many more years of research to be done before we can determine this," said Krause.


'"/>

Source:Yale University


Page: 1

Related biology news :

1. Stem cells in bone marrow replenish mouse ovaries
2. Malfunctioning bone marrow cells sabotage nerve cells in diabetes
3. Bone marrow stem cells may heal hearts even years after heart attacks
4. New research demonstrates bone-marrow derived stem cells can reverse genetic kidney disease
5. Bone marrow may restore cells lost in vision diseases
6. Healing the heart with bone marrow cells
7. Leukemic cells find safe haven in bone marrow
8. Early-stage sperm cells created from human bone marrow
9. Wisconsin scientists grow critical nerve cells
10. Spleen may be source of versatile stem cells
11. Researchers discover way to make cells in the eye sensitive to light
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Bone marrow cells can become functional gut lining cells

(Date:8/20/2015)... Aug. 20, 2015   Sensory, Inc ., ... the user experience and security of consumer electronics ... announced that its TrulySecure™ is the ... to be FIDO Certified™. The FIDO ... with the FIDO UAF (Universal Authentication Framework) 1.0 ...
(Date:8/17/2015)... 2015  NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" ... the growing mobile commerce market and creator of the ... Q4 2015. The new marketing campaign is being spearheaded ... Marketing Group ( http://amplitudemarketing.com/ ) and TPMG ( http://tmpg.com/ ... in retail driven marketing and brand awareness and has ...
(Date:8/11/2015)... 2015 Today, ZUK announced its Android smartphone ... as expected revenues in 2015 that relate to sales of FPC1155 ... of approximately 2,200 MSEK for 2015. Jörgen Lantto, CEO ... prominent smartphone manufacturer in China ... FPC1 155 for Z1 , ...
Breaking Biology News(10 mins):TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 2TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 3TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 4TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 5NXT-ID, Inc. Launches Sales Campaign for Wocket Smart Wallet with Award Winning Marketing Team 2NXT-ID, Inc. Launches Sales Campaign for Wocket Smart Wallet with Award Winning Marketing Team 3FPC's Touch Fingerprint Sensor FPC1155 in ZUK's Smartphone Z1 2
... over millions of years to maximise efficiency of movement ... designs for barely a century. So shouldn,t we ... and engineers from across the US have been doing ... tails of whales and dolphins, these scientists have discovered ...
... findings at the 11th International Coral Reef Symposium in Fort ... Dust Poses Threat to Coral Reefs and Human Health: ... the Americas may be a threat to marine organisms and ... researchers with the U.S. Geological Survey, Oregon State University, and ...
... with a researcher, please contact the Communications and External Relations ... more information on ORNL and its research and development activities, ... have a general media-related question or comment, you can send ... -- Spent fuel pellets . . . ...
Cached Biology News:Whales and dolphins influence new wind turbine design 2The good, the bad and the smelly: USGS at the 2008 Coral Reef Symposium 2The good, the bad and the smelly: USGS at the 2008 Coral Reef Symposium 3The good, the bad and the smelly: USGS at the 2008 Coral Reef Symposium 4The good, the bad and the smelly: USGS at the 2008 Coral Reef Symposium 5The good, the bad and the smelly: USGS at the 2008 Coral Reef Symposium 6The good, the bad and the smelly: USGS at the 2008 Coral Reef Symposium 7The good, the bad and the smelly: USGS at the 2008 Coral Reef Symposium 8The good, the bad and the smelly: USGS at the 2008 Coral Reef Symposium 9Story tips from the Department of Energy's Oak Ridge National Laboratory, July 2008 2Story tips from the Department of Energy's Oak Ridge National Laboratory, July 2008 3
(Date:9/2/2015)... Wellinton, Florida (PRWEB) , ... September 02, 2015 ... ... has been treated and managed with the use of special anti-vascular endothelial growth ... occurs in many more patients, currently does not have a scientific protocol for ...
(Date:9/2/2015)... 2015 Biovista Inc. is glad ... 2015 BeHEARD science challenge, a global competition hosted by ... access to the latest life science innovations and technologies. ... pathway analytics capability to support Steven Laffoon ... study of Niemann-Pick Disease Type A (NPA), a rare ...
(Date:9/2/2015)... Aytu BioScience, Inc. (OTCQB: AYTU), a specialty ... related conditions, announced today that it has closed the ... financing, raising a total of $5.175 million, which includes ... Josh Disbrow , Chief Executive Officer ... intended to be used to conduct clinical studies for ...
(Date:9/2/2015)... CHARLOTTESVILLE, Virginia , September 2, 2015 /PRNewswire/ ... Sponsoring der Gewinner des Wettbewerbs BeHEARD von 2015 ... einen internationalen vom Rare Genomics Institute. ... Wirksamkeit von Medikamenten für die Behandlung anderer Krankheiten ... wurde, Steven Laffoon und sein Team ...
Breaking Biology Technology:StemCell GeneticMed Announces That It Has Started Stem Cell Treatments for Age Related Dry Macular Degeneration (AMG) 2Biovista Sponsors Wylder Nation Foundation's Research on Acid Sphingomyelinase Deficiency 2Aytu BioScience Completes $5.175 Million Private Placement 2Aytu BioScience Completes $5.175 Million Private Placement 3Biovista sponsert die Forschung von Wylder Nation Foundation zum Thema Mangel an saurer Sphingomyelinase 2
... INDIANAPOLIS, Sept. 10 BioStorage Technologies, Inc.,(BST) announced ... Power,& Light Company (IPL) to purchase electricity generated ... Power Option voluntary,program. By offsetting the use of ... to become completely carbon-neutral by 2009. BST ...
... BEIJING and CLAREMONT, Calif., Sept. 10 /Xinhua-PRNewswire-FirstCall/,-- Kiwa ... that the China Green Food Association of the ... as "Green Food CGFA,Recommend Brands." The vice ... has already,confirmed over 13 million hm2 (hectares) of ...
... Ireland, Sept. 10 /PRNewswire-FirstCall/,-- Concuity, a healthcare division ... launch of its newly designed website --, http://www.concuity.com ... of,visitors to quickly find information about Concuity,s products ... for financial,professionals in the healthcare industry seeking ways ...
Cached Biology Technology:BioStorage Technologies Becomes Green Powered through the Use of 100% Certified Renewable Energy 2BioStorage Technologies Becomes Green Powered through the Use of 100% Certified Renewable Energy 3BioStorage Technologies Becomes Green Powered through the Use of 100% Certified Renewable Energy 4Kiwa Bio-Tech Named Recommended Brand by the China Green Food Association 2Concuity Announces the Launch of Its New Fully Accessible Website - Concuity.Com 2Concuity Announces the Launch of Its New Fully Accessible Website - Concuity.Com 3
... The wide mini ReadySub-Cell GT cell and ... horizontal gel electrophoresis of nucleic acids in agarose ... buffer tank, lid with cables and electrodes, and ... and 220-240 V, provides output of 10-300 V, ...
... and you reduce the chance of error. ... 8000. Developed using Beckman Coulters extensive experience ... electrophoresis technology, the CEQ 8000 is a ... automatically fills the capillary array with a ...
... 2000 Capillary Electrophoresis System uses revolutionary ... electrophoresis (SPE), urine protein electrophoresis and ... accurate analysis. The system is truly ... and no staining to process patient ...
The filter 695RDF55 Reflect 635 for the Molecular Imager FX is a band pass filter for Cy5 and Alexa Fluor 635 dyes....
Biology Products: