Navigation Links
Bone marrow cells can become functional gut lining cells

Researchers report the discovery that cells used in bone marrow transplantation can develop into new cells lining the gut, according to a study by Yale School of Medicine in the Proceedings of the National Academy of Sciences.

The study showed that bone marrow derived cells can differentiate into functional gastrointestinal epithelial cells after bone marrow transplantation. Research was from the laboratory of Diane Krause, M.D., professor of Laboratory Medicine and senior author of the study, in collaboration with Marie Egan, M.D., associate professor of pediatrics, respiratory medicine, and cellular and molecular physiology.

"We demonstrated that the cells were functional by showing that they express functional chloride channels (known as CFTR, or cystic fibrosis transmembrane conductance regulator) which are necessary for fluid balance in the gut," Krause said.

The researchers used mice that do not have this chloride channel. After bone marrow transplantation from donor mice that do have the chloride channel, recipient mice had some normal chloride channel activity.

Alhough this is exciting, the levels of donor derived gut cells are currently far too low to be used as a treatment for cystic fibrosis, an inherited disease in which the organs, especially those of the pancreas, lungs, and intestines, become clogged with thick mucus.

"We hope this finding will have implications for cystic fibrosis, but this is a first step and there are many, many more years of research to be done before we can determine this," said Krause.


'"/>

Source:Yale University


Page: 1

Related biology news :

1. Stem cells in bone marrow replenish mouse ovaries
2. Malfunctioning bone marrow cells sabotage nerve cells in diabetes
3. Bone marrow stem cells may heal hearts even years after heart attacks
4. New research demonstrates bone-marrow derived stem cells can reverse genetic kidney disease
5. Bone marrow may restore cells lost in vision diseases
6. Healing the heart with bone marrow cells
7. Leukemic cells find safe haven in bone marrow
8. Early-stage sperm cells created from human bone marrow
9. Wisconsin scientists grow critical nerve cells
10. Spleen may be source of versatile stem cells
11. Researchers discover way to make cells in the eye sensitive to light
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/12/2017)... 2017  Trovagene, Inc. (NASDAQ: TROV ), ... announced that it has signed agreements with seven strategic ... Middle East for commercialization of ... first wave of international distribution agreements for Trovagene,s CLIA ... The initial partners will introduce Trovagene,s liquid ...
(Date:1/6/2017)... 2017  Privately-held CalciMedica, Inc., announced that it ... of a novel calcium release-activated calcium (CRAC) channel ... Acute pancreatitis, sudden painful inflammation of ... can be very serious.  In severe cases it can ... hospital stays, time in the ICU and substantial ...
(Date:1/3/2017)... , Jan. 3, 2017 Onitor, provider of ... of Onitor Track, an innovative biometric data-driven program designed ... this month at the 2017 Consumer Electronics Show (CES) ... In the U.S., the World Health Organization (WHO), ... two-thirds of adults who are overweight or obese. WHO ...
Breaking Biology News(10 mins):
(Date:1/21/2017)... -- Bioptix, Inc. (Nasdaq: BIOP ... 14, 2017 the Board of Directors of the Company ... certain employees associated with the September 2016 acquisition of ... on January 16, 2017 and terminations are expected to ... severance benefits in certain circumstances of up to one ...
(Date:1/20/2017)... ... January 20, 2017 , ... The two newest companies to join the ... Vironika, a spin out from The Wistar Institute, and Sanguis, launched by a trio ... Market Street. , Vironika is developing a treatment for a chronic viral infection ...
(Date:1/20/2017)... NEW YORK , January 20, 2017 ... Health Organization, cancer is one of leading causes of ... in 2012. Although the number of cancer related deaths ... since 1990. Rising in incidence rate of various cancers ... According to a research report by Global Market Insights, ...
(Date:1/19/2017)... 19, 2017  Market Research Future has a half cooked research ... Biopsy is growing rapidly and expected to reach USD 450 Million ... ... Biopsy Market has been assessed as a swiftly growing market and ... in the coming future. There has been a tremendous growth in ...
Breaking Biology Technology: