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Bone and cartilage growth to blame for heart valve disease

fections in the heart, and sudden death may occur in 15 to 20 percent of people who have symptoms.

Dr. Rajamannan has focused her research for the past seven years on advancing the knowledge of mechanisms of aortic and mitral valve disease using animal models and human studies. "I wanted to know why diseased valves had were hardened with a glassy whitish appearance ?totally different than healthy tissue, which indicated to me that the actual structure of the valves had changed," she says. Dr. Rajamannan has been awarded over $750,000 in grants from the NIH and the American Heart Association to pursue this research.

Dr. Rajamannan's laboratory was the first to treat animals with calcifications in heart valves with medications called statins, the same drugs that are currently used to treat high cholesterol. In an early pioneering study, animals treated with statins had significantly less heart valve disease than the control animals that were not treated. The results from the animal studies and now with the human valves demonstrate that valvular heart disease has an active biology which can be treated with medications similar to that of coronary artery disease.

"As with the majority of people in the field who hear about this research, I was surprised when Dr. Rajamannan's unique observations indicated that the process of valve degeneration is instead an active process, linked to inflammation and cellular growth," says Robert Bonow, MD, co-director of the Bluhm Cardiovascular Institute. "The exciting news is that this line of research suggests that there may be medical treatments in the future that could either treat this disease process."

This research was completed with the support of an American Heart Association Grant-in-Aid (0350564Z) and a grant from the US National Institutes of Health (1K08HL073927-01).

Dr. Rajamannan's research will be featured at the American College of Cardiology's 2006 Heart Valve Summit being hel
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Source:Northwestern Memorial Hospital


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