Navigation Links
Blood sugar's manufacture limited by building blocks' supply

Researchers have discovered a factor that controls blood sugar's manufacture in a novel way: by limiting the supply of its building blocks. The findings are reported in the April issue of the journal Cell Metabolism, published by Cell Press.

The study found that mice deficient for KLF15, a member of the so-called Krüppel-like family of transcription factors, become severely lacking in the blood sugar glucose—a primary energy source for the body and the sole source for the brain—after a period of overnight fasting. The researchers traced that deficiency back to an inability to produce new glucose in the liver, a process known as gluconeogenesis, due to a defect in the processing of amino acids. Amino acids are the main ingredients of proteins and the source of a key substrate in blood sugar's production.

"Gluconeogenesis is a complicated process," said Mukesh K. Jain of Case Western Reserve University. "It fundamentally requires two big things: the building blocks and the [glucose-building] enzymes that make it all happen. A lot of previous work has focused on the enzymes."

"We've found the first defect [in glucose production] due to a loss of substrate," added Susan Gray of Brigham and Women's Hospital.

During fasting, the supply of glucose derived from food dries up, Gray explained. In response, the body first breaks down liver glycogen, the principal storage form of glucose. However, the body "goes through those stores overnight," she said.

Once the reserves are depleted, the body must rely on the synthesis of new glucose, primarily in the liver, to prevent a life-threatening shortage, a condition known as hypoglycemia. The de novo synthesis of glucose depends on the availability of a substrate molecule that comes from an amino acid.

The researchers found that mice with a targeted deletion of KLF15 display severe hypoglycemia after an overnight fast. They further found evidence that defective amino acid brea
'"/>

Source:Cell Press


Page: 1 2

Related biology news :

1. Placenta Is A Rich Source Of Blood Stem Cells
2. Infants With Rare Genetic Disease Saved by Cord Blood Stem Cells
3. White Blood Cell Waste Disposal System Plays Critical Regulatory Role
4. Mystery Blood Vessel Disorder Implicated In Mini Strokes
5. Infants with Rare Genetic Disease Saved By Cord Blood Stem Cells
6. Young Blood Revives Aging Muscles, Stanford Researchers Find
7. Stem Cells to Solve the Blood Shortage Problem?
8. Blood flow in brain takes a twist, affecting views of Alzheimers
9. Blood test predicts success of quitting smoking using the nicotine patch
10. Blood-compatible nanoscale materials possible using heparin
11. Blood transfusion-transmitted infections: A global perspective
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Blood sugar manufacture limited building blocks supply

(Date:4/14/2015)... NEW YORK , April 14, 2015 /PRNewswire/ ... Fast IDentity Online (FIDO ® ) Alliance tm ... standards-based specifications. FIDO members commit to share technology ... authentication methods that are interoperable, more secure and ... specifications enable biometric identity verification that protects sensitive ...
(Date:4/13/2015)... YORK , April 13, 2015 ... by TechSci Research, "Global Biometrics Market Forecast & Opportunities, ... register a CAGR of around 14% till 2020. ... governments for large scale implementation and review of ... and launch of new products with greater efficiency, ...
(Date:4/10/2015)... , April 10, 2015 Research ... of the "Security Competitive Profiles - NEC" ... , NEC will continue to supply a ... the market, with a company focus on the development ... Winning opportunities in the Asia-Pacific ...
Breaking Biology News(10 mins):HYPR Corp. Joins the FIDO Alliance 2HYPR Corp. Joins the FIDO Alliance 3Global Biometrics Market to Cross US$ 21 Billion by 2020: TechSci Research 2NEC Security Competitive Profile 2015 2
... inside each cell, a little engine called RNA polymerase II ... the nucleus that get carried to production units in the ... researchers at the University of Michigan Medical School have shown ... for damage. When certain types of damage in DNA halt ...
... LAFAYETTE, Ind. - A biomedical engineer at Purdue University ... that promises to be more effective than standard CPR ... by 25 percent over the current method. A ... a success rate of 5 percent to 10 percent, ...
... (09/05/07)--It is well established that a child,s brain has ... the extent to which such plasticity exists in the ... and Johns Hopkins University have used converging evidence from ... adult visual cortex does indeed reorganize-and that the change ...
Cached Biology News:Enzyme alerts cell's powerful army to repair DNA damage 2Enzyme alerts cell's powerful army to repair DNA damage 3New CPR promises better results by compressing abdomen, not Chest 2New CPR promises better results by compressing abdomen, not Chest 3New CPR promises better results by compressing abdomen, not Chest 4Adult brain can change, study confirms 2
(Date:4/16/2015)... Associates IRB, Inc., the industry-leading central IRB in customer ... Laboratory Drive in the heart of Research ... house review board and service staff, which will be ... service to clients. CBRE | ... while Capital Associates Management, LLC represented the landlord.   ...
(Date:4/16/2015)... 2015 According to the 2014 ... outside source was ranked first among the leading ... to lifting, pushing, pulling, holding, carrying, or throwing ... The David Round Company takes statistics like this ... hard to develop and design equipment that prevents ...
(Date:4/16/2015)... IA (PRWEB) April 16, 2015 ... announces that the prestigious 2015 Borlaug CAST Communication ... faculty member at Tuskegee University in Alabama. Award ... written material; public presentations; and/or the use of ... in all three areas. As a specialist in ...
(Date:4/16/2015)... /PRNewswire/ - Portage Biotech Inc. ("Portage" or "the Company" ... pleased to announce that the Company will be presenting ... to be held in London, UK ... Mr. James Mellon , a director of Portage, ... key programs at its subsidiaries, Portage Pharmaceuticals Ltd. ("PPL"), ...
Breaking Biology Technology:Schulman IRB to Open Office in Research Triangle Park, N.C. 2The David Round Company Helps Companies Meet OSHA Standards by Combining Safety, Ergonomics, and Productivity 2The 2015 Borlaug CAST Communication Award Goes to Channapatna Prakash 2Portage to Present at Master Investor 2015 in London, UK 2Portage to Present at Master Investor 2015 in London, UK 3Portage to Present at Master Investor 2015 in London, UK 4
... - TOPIC: The state of the microRNA market and the ... current and potential impact on drug discovery, molecular, ... Tuesday, March 31, 2009, - TIME: ... - HOST: Christi Bird, Senior Research Analyst, Healthcare, ...
... March 30 BioVex Inc, a company developing new ... and infectious disease, announced today it has raised $40 ... private financing.The placement was led by Forbion Capital Partners, ... Agricole Private Equity, Harris & Harris Group, Innoven Partners, ...
... software for clinical research trials has named Jovianna DiCarlo President ... years experience driving new pharmaceutical therapeutics and devices through the ... to commercialization. , ... Frederick, MD ...
Cached Biology Technology:Frost & Sullivan Hosts Presentation on MicroRNAs: From Stem Cells and Cancer to Diagnostics and Therapeutics 2BioVex Raises $40 Million in First Close of Series F Financing 2BioVex Raises $40 Million in First Close of Series F Financing 3Jovianna DiCarlo Named ConsentSolutions, Inc. President & Chief Executive Officer 2
...
... This monoclonal antibody recognizes 30% ... unrelated individuals. It does not ... proteins lacking rheumatoid factor nor with ... be used in ELISA to detect ...
...
Human VEGF R2 (KDR) MAb (Clone 89106)...
Biology Products: