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Blood flow in brain takes a twist, affecting views of Alzheimer's

ergaard said that while it is new to find that astrocytes can regulate blood flow, the finding shouldn't be entirely surprising. She said that astrocytes physically touch both synapses ?the spaces between neurons that are crucial to brain activity ?and blood vessels. In fact, "footprints" of astrocytes are literally all over blood vessels in the brain: Portions of astrocytes known as "astrocytic endfeet" wrap around nearly all the blood vessels in the brain.

Previously a few scientists have looked at slices of brain tissue and come up with hints that astrocytes might regulate blood flow in brain tissue. The current research, funded by the National Institute of Neurological Disorders and Stroke, relies on a sophisticated laser system developed by Nedergaard to study the activity of astrocytes in living organisms. The team used a fluorescent dye to light up the blood vessels, then put a special form of the chemical calcium into astrocytes. They used one laser to activate the calcium, and another laser to monitor how astrocytes processed the chemical. They found that astrocytes caused blood vessels to dilate.


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Source:University of Rochester Medical Center


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