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Blood-compatible nanoscale materials possible using heparin

uthors of the paper are Shaker Mousa, director of the Pharmaceutical Research Institute at Albany College of Pharmacy, and Aravind Vijayaraghavan, a recent doctoral graduate in materials science and engineering at Rensselaer. Funding for this research was provided by the National Institutes of Health.

Recent results related to this work have been published online in the journals Langmuir ("Blood Compatible Nanotubes � Nano-based Neoproteoglycans," Mar. 11, 2006) and Biomacromolecules ("Preparation of Biopolymer Fibers by Electrospinning from Room Temperature Ionic Liquids," Jan. 26, 2006). Provisional patents have been filed by Rensselaer Polytechnic Institute.

Research in Linhardt's group at the Center for Biotechnology and Interdisciplinary Studies at Rensselaer focuses on complex carbohydrates such as heparin. After determining the structure of these molecules, researchers study their biological activities to establish a structure-activity relationship that may reveal lead compounds for new drug development. Recent discoveries include a synthetic method for preparation of heparin in quantities large enough for use in medical treatment.


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Source:Rensselaer Polytechnic Institute


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