Navigation Links
Blood-compatible nanoscale materials possible using heparin

Researchers from Rensselaer Polytechnic Institute have engineered nanoscale materials that are blood compatible using heparin, an anticoagulant. The heparin biomaterials have potential for use as medical devices and in medical treatments such as kidney dialysis.

The researchers prepared several materials with heparin composites or coatings, including carbon nanotubes, nanofibers, and membranes with nanosized pores, and then demonstrated the materials' high compatibility with blood. Heparin is a common therapeutic used to maintain blood flow or prevent clotting during medical procedures and treatments.

The researchers demonstrated the composite heparin membrane with nanopores could work as an artificial kidney, or dialyzer, by filtering the blood and maintaining its flow. The presence of this blood-compatible dialyzer could potentially eliminate the need for systemic administration of heparin to the patient during kidney dialysis, the researchers say.

The heparin-coated membranes are described in a paper titled "Ionic Liquid-Derived Blood Compatible Membranes for Kidney Dialysis," published online Apr. 24 in advance of print in the Journal of Biomedical Materials Research.

"These heparin composite membranes and fibers and coated carbon nanotubes are an enabling technology," says Saravanababu Murugesan, a recent doctoral graduate in chemical and biological engineering at Rensselaer and lead author of the paper. "Our results show these novel materials have great promise in the development of improved medical devices that are blood compatible."

The research team is led by Robert Linhardt, the Ann and John H. Broadbent Jr. '59 Senior Constellation Professor of Biocatalysis and Metabolic Engineering at Rensselaer, and includes collaboration with Pulickel Ajayan, the Henry Burlage Professor of Materials Science and Engineering, and Omkaram "Om" Nalamasu, professor of materials science and engineering, at Rensselaer. Additional co-a uthors of the paper are Shaker Mousa, director of the Pharmaceutical Research Institute at Albany College of Pharmacy, and Aravind Vijayaraghavan, a recent doctoral graduate in materials science and engineering at Rensselaer. Funding for this research was provided by the National Institutes of Health.

Recent results related to this work have been published online in the journals Langmuir ("Blood Compatible Nanotubes � Nano-based Neoproteoglycans," Mar. 11, 2006) and Biomacromolecules ("Preparation of Biopolymer Fibers by Electrospinning from Room Temperature Ionic Liquids," Jan. 26, 2006). Provisional patents have been filed by Rensselaer Polytechnic Institute.

Research in Linhardt's group at the Center for Biotechnology and Interdisciplinary Studies at Rensselaer focuses on complex carbohydrates such as heparin. After determining the structure of these molecules, researchers study their biological activities to establish a structure-activity relationship that may reveal lead compounds for new drug development. Recent discoveries include a synthetic method for preparation of heparin in quantities large enough for use in medical treatment.


'"/>

Source:Rensselaer Polytechnic Institute


Related biology news :

1. Marine sponge yields nanoscale secrets
2. Rice scientists make first nanoscale pH meter
3. Embryonic stem cells do better on bumpy nanoscale mattress
4. Spelling out cancer on the nanoscale
5. Researchers to develop active nanoscale surfaces for biological separations
6. Fantastic Voyage: A new nanoscale view of the biological world
7. Bones at the nanoscale
8. Penn researcher shows that DNA gets kinky easily at the nanoscale
9. Purdue proves concept of using nano-materials for drug discovery
10. UCLA scientists store materials in cells natural vaults
11. Nanotextured implant materials: blending in, not fighting back
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/11/2017)... GARDENS, Fla. , April 11, 2017 /PRNewswire/ ... management and secure authentication solutions, today announced that ... by Intelligence Advanced Research Projects Activity (IARPA) to ... IARPA,s Thor program. "Innovation has been ... and IARPA,s Thor program will allow us to ...
(Date:4/11/2017)... BROOKLYN, N.Y. , April 11, 2017 /PRNewswire-USNewswire/ ... identical fingerprints, but researchers at the New York ... University College of Engineering have found that partial ... fingerprint-based security systems used in mobile phones and ... previously thought. The vulnerability lies in ...
(Date:4/6/2017)... 6, 2017 Forecasts by Product ... Readers, by End-Use (Transportation & Logistics, Government & Public ... & Fossil Generation Facility, Nuclear Power), Industrial, Retail, Business ... Are you looking for a definitive report on ... ...
Breaking Biology News(10 mins):
(Date:8/14/2017)... ... August 14, 2017 , ... Every year, millions of dollars ... antibody community have recently come together to address this antibody crisis and develop ... , The team at Thermo Fisher Scientific has arranged for ...
(Date:8/11/2017)... San Antonio, Texas (PRWEB) , ... August 11, 2017 , ... ... launching a rebranding campaign this month that will incorporate important key elements including a ... to thank the community that has supported them, Bill Miller has partnered with the ...
(Date:8/10/2017)... (PRWEB) , ... August 09, 2017 , ... ... the classroom next week-- as students. From August 14th through the 16th, the ... institute, which debuted in the summer of 2016, provides Philadelphia-based middle school educators ...
(Date:8/10/2017)... ... August 09, 2017 , ... ... international biomedical optics laboratories — the Wellman Center for Photomedicine, the Manstein Lab ... Lübeck and the Beckman Laser Institute at University of California, Irvine — and ...
Breaking Biology Technology: