Navigation Links
Blood-brain barrier breached by new therapeutic strategy

A major obstacle in the treatment of infections and other diseases of the brain is the blood-brain barrier, which prevents systemically delivered therapeutic drugs from reaching the brain. Grantees of the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, have now shown that a short protein (peptide) from the rabies virus can carry a strip of therapeutic material into the brain via intravenous administration. Once delivered to the nerve cells of the brain, the strip, called a small interfering RNA (siRNA), was shown to protect mice from infection caused by the Japanese encephalitis virus (JEV).

Manjunath N. Swamy, M.D., of the CBR Institute for Biomedical Research and Harvard Medical School in Boston, and his colleagues used JEV to infect the brains of mice. They then injected the antiviral siRNA bound to the rabies peptide through the tail veins in one group of mice, while other mice served as control groups. All the mice in the control groups died from JEV infection; in contrast, 80 percent of the mice that got the antiviral siRNA linked to the rabies peptide survived. These experiments demonstrate how the rabies peptide can be used to deliver antiviral siRNA across the blood-brain barrier and into nerve cells in the brain. Once inside brain nerve cells, the antiviral siRNA can silence key viral genes to control the infection. Furthermore, repeated administration of the RNA interference therapy did not trigger inflammation or antibodies to the peptide.

Currently, doctors use various methods to deliver therapeutic drugs directly into the brain. These methods involve invasive procedures that result in only localized delivery around the site of injection. The new research provides a safe and non-invasive method for delivering therapeutic molecules across the blood-brain barrier. It has the potential to be applied to the treatment of a variety of brain infections and diseases. The researchers are now
'"/>

Source:NIH/National Institute of Allergy and Infectious Diseases


Page: 1 2

Related biology news :

1. Slipping past the blood brain barrier: Research shows potential treatment for brain cancer
2. Primate virus jumps species barrier to humans for first time in Asia
3. Divergent mating systems and parental conflict as a barrier to hybridization in flowering plants
4. Cell barrier shows why bird flu not so easily spread among humans
5. Study reveals candidate targets for anti-retroviral therapeutics
6. Tetanus toxin found to have therapeutic properties
7. Dendritic cells offer new therapeutic target for drugs to treat MS and other autoimmune disease
8. Greasing interferons gears may pave way to greater therapeutic benefits, fewer side effects
9. Anthrax inhibitor counteracts toxin, may lead to new therapeutics
10. Nano-particles effective in killing cancer with one-two punch of chemotherapeutics
11. T cells activated to fight HIV basis for dendritic cell therapeutic vaccine
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Blood brain barrier breached new therapeutic strategy

(Date:11/21/2014)... Strict laws against distracted driving and the ... American and European automotive sector towards gesture recognition technologies. ... that are intuitive and able to retrieve information with ... New analysis from Frost & Sullivan,s Strategic ... Europe and North America ...
(Date:11/18/2014)... 2014   News Highlights: ... develop The Partners Data Lake, an agile data ... Lake will allow researcher and clinicians to explore ... the lives of patients , The Partners ... across the Partners system, breaking down physical barriers ...
(Date:11/12/2014)... BEACH GARDENS, Fla. , Nov. 12, 2014 /PRNewswire/ ... solutions, announced today that its U.are.U ® fingerprint ... retail bakery chain in Central Mexico ... in June 2014 to eliminate payroll issues caused by ... Prior to installing the U.are.U fingerprint readers, Montparnasse relied ...
Breaking Biology News(10 mins):Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 2Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 3Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 2Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 3Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 5Montparnasse Pasteleria Achieves Time and Attendance Transparency with Crossmatch U.are.U Fingerprint Readers 2
... Institutes have discovered that environmental factors critically influence the ... cell--that is derived from adult skin cells. This discovery ... also advancing science closer to stem cell-based therapies to ... Senior Investigator Shinya Yamanaka, MD, PhD, have for the ...
... 4 July 2012 The Raffles Museum of Biodiversity ... Faculty of Science today launched a new book titled ... the precious biodiversity found in Singapore,s rainforests and the ... RMBR also introduced the "Digital Nature Archive of Singapore" ...
... out that the olfactory system in hermit crabs is ... While flies have a very sensitive sense of smell ... the air, crabs recognize only a few odors, such ... seawater. Humidity significantly enhanced electrical signals induced in their ...
Cached Biology News:Gladstone scientists identify critical process in stem cell development 2Gladstone scientists identify critical process in stem cell development 3NUS launches new book on Singapore's rainforests and new free digital nature archive 2Humidity increases odor perception in terrestrial hermit crabs 2Humidity increases odor perception in terrestrial hermit crabs 3
(Date:11/24/2014)... , UAE, November 24, 2014 ... Hamdan Bin Rashid Al Maktoum Awards for Medical Sciences", ... Dubai, United Arab Emirates , on 15 ... ) , The Carter Center which won ... is actively involved in numerous programs that aim to ...
(Date:11/24/2014)... Nov. 24, 2014 VolitionRx Limited (OTCQB: ... for cancer and other conditions, today announced that data from ... Science for Business BioWin Day 2014, being held November 26, ... come from VolitionRx,s lung cancer pilot study, the samples for ... Hospitalier Universitaire (CHU) de Liege in Belgium ...
(Date:11/24/2014)... SAN FRANCISCO, Calif. , Nov. 24, 2014   ... that Bonnie H. Anderson , president and chief executive ... Piper Jaffray 26 th Annual Healthcare Conference on Tuesday, ... New York . The live audio webcast ... at http://investor.veracyte.com . Please connect to the website at ...
(Date:11/24/2014)... November 24, 2014 Continental Clinical ... populations into clinical trials at its mid-Atlantic late-phase ... “Continental was created with the idea of closing ... fundamental role in medical advances," said Continental's CEO, ... experiment to the immortal cell line of Henrietta ...
Breaking Biology Technology:Five US Winners Among Recipients of Hamdan Medical Awards 2VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 2VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 3VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 4VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 5VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 6Veracyte to Present at the Piper Jaffray 26th Annual Healthcare Conference 2At Continental Clinical Solutions, CEO Saleh Stevens Focuses on Diversity in Clinical Trial Recruitment at Maryland Site 2At Continental Clinical Solutions, CEO Saleh Stevens Focuses on Diversity in Clinical Trial Recruitment at Maryland Site 3
... 11 /PRNewswire-Asia/ -- Sinovac Biotech Ltd.,(NYSE Amex: SVA ... it will host a conference call on Wednesday, August 19, ... financial results for the period,ended June 30, 2009 and provide ... To access the conference call, please dial 1-877-407-4018 (USA) ...
... Peripheral Drug-Eluting Stent Now Available in Europe , ... (NASDAQ: ANPI , TSX: ANP) today announced ... reported CE Mark approval and limited commercial launch of ... approval represents a global landmark in bringing drug-eluting stent ...
... , , , ... Systems today announced that BD Biosciences, a segment of BD ... its Search and Pathway Navigation technologies into its new website. ... Biosciences will enable its research customers to quickly and easily ...
Cached Biology Technology:Sinovac to Host Conference Call to Report 2009 Second Quarter Financial Results 2Angiotech's Licensee, Cook Medical, Announces CE Mark Approval and European Launch of the Zilver(R) PTX(R) Stent 2Angiotech's Licensee, Cook Medical, Announces CE Mark Approval and European Launch of the Zilver(R) PTX(R) Stent 3Angiotech's Licensee, Cook Medical, Announces CE Mark Approval and European Launch of the Zilver(R) PTX(R) Stent 4Angiotech's Licensee, Cook Medical, Announces CE Mark Approval and European Launch of the Zilver(R) PTX(R) Stent 5Angiotech's Licensee, Cook Medical, Announces CE Mark Approval and European Launch of the Zilver(R) PTX(R) Stent 6Angiotech's Licensee, Cook Medical, Announces CE Mark Approval and European Launch of the Zilver(R) PTX(R) Stent 7Angiotech's Licensee, Cook Medical, Announces CE Mark Approval and European Launch of the Zilver(R) PTX(R) Stent 8Ingenuity's Technology Powers BD Cell Pathways Tool on New BD Biosciences Website 2
...
DONOR BOVINE SERUM AND PLASMA...
Full-length cDNA 5-PRIME end of clone CS0DE013YM09 of Placenta of Homo sapiens (human). [Source:Uniprot/SPTREMBL;Acc:Q86TS7] Antigen: Recombinant Protein Epitope Signature Tag (PrEST)....
No description available in Ensembl. Antigen: Recombinant Protein Epitope Signature Tag (PrEST)....
Biology Products: