Navigation Links
Blocking the nerve receptor EP1 in mouse models reduces brain damage caused by stroke

713 works specifically at that receptor."

Finally, the Hopkins scientists showed that stimulation of EP1 receptors triggers the damage caused when blood flow is suddenly restored after a stroke. The team blocked blood flow in one of the main arteries feeding specific areas of the brain in mice lacking the gene for the EP1 receptor and then restored blood flow after 90 minutes. The area of brain damage (infarct size) in the mice lacking the EP1 gene was only about 57 percent of that seen in normal mice that underwent the same treatment. This provided additional evidence that brain damage caused by ischemia depends in large part on the stimulation of EP1 receptors, the researchers reported.

"Our results strongly suggest that given the side effects associated with COX inhibitors, we should focus our efforts on developing drugs that block the EP1 receptor instead of inhibiting COX-2 activity," said Doré.

Doré has applied for a patent covering the prevention and/or treatment of neurodegenerative diseases by administering agents that block the EP1 receptor.


'"/>

Source:Johns Hopkins Medical Institutions


Page: 1 2 3

Related biology news :

1. Blocking immune cell action increases Alzheimers-associated protein deposits
2. Wisconsin scientists grow critical nerve cells
3. Clam embryo study shows pollutant mixture adversely affects nerve cell development
4. Zebrafish may hold key to understanding human nerve cell development
5. New component of the brakes on nerve regeneration found
6. Cerebral navigation: How do nerve fibers know what direction to grow in?
7. Molecular messengers perform a crucial role in the ability of injured nerve cells to heal themselves
8. Diabetic nerve therapy shows striking results
9. Malfunctioning bone marrow cells sabotage nerve cells in diabetes
10. UIC researchers show protein routes messages in nerve cells
11. Researchers find molecule that inhibits regrowth of spinal nerve cells
Post Your Comments:
(Date:3/12/2015)... Va. , March 12, 2015 IriTech, ... and a member of the Texas Instruments Design Network, ... Naidu has demonstrated its IriShield USB MK2120U device ... scanning facility for pension distribution. The ... assembled to be marketed in India ...
(Date:3/12/2015)... -- Beta Systems today announced Fast ... (IAM) solution for a fixed price and with ... IAM package, customers benefit from the 30 years, ... implementations across different industries. The new fixed-price IAM ... necessary services and consulting. It spans the implementation ...
(Date:3/11/2015)... , Mar. 11, 2015 Research and Markets ... of the "Access Control Market by Product, Application ... 2020" report to their offering. , ... expected to reach $10.4 billion by 2020, with an ... market report covers the products types such as contact ...
Breaking Biology News(10 mins):Indian States See IriTech's Scanner Bolstering Efficiency of Authentication for Aadhaar 2Indian States See IriTech's Scanner Bolstering Efficiency of Authentication for Aadhaar 3Beta Systems Fast Forward IAM Available Now: a Standardized IAM Package at a Fixed Price 2Global Access Control (Cards & Readers, Biometrics, Controllers, Management Software) Market 2015-2020 - Analysis of the $10 Billion Market 2
... that a new strain of mice offers the first real ... should greatly aid the development of new drugs for the ... develops a malignancy that closely mimics chronic lymphocytic leukemia (CLL). ... development of new treatments for CLL as well as research ...
... discovered that neurons in the brains of mice sprout ... new experiences. The new connections alter the circuitry of ... researchers said their findings aid understanding of how procedural ... of learning is used in mastering skills such as ...
... Orange juice and other foods traditionally not associated with ... disease, although rare. Public health officials should be ... presenting today at the 106th General Meeting of the ... we find out about the behavior of microorganisms in ...
Cached Biology News:Mouse mimics chronic leukemia, will aid drug development 2Long-term changes in experience cause neurons to sprout new long-lasting connections 2Long-term changes in experience cause neurons to sprout new long-lasting connections 3Despite acidity, orange juice could still be a source of foodborne disease 2
(Date:3/30/2015)... 30, 2015    Intrexon Corporation (NYSE: ... and Merck Serono, the biopharmaceutical business of Merck ... announced an exclusive strategic collaboration and license agreement ... (CAR-T) cancer therapies. This collaboration advances Merck Serono,s ... modulate the immune system,s natural ability to fight ...
(Date:3/30/2015)... FLORHAM PARK, N.J. , March 30, 2015 ... antagonist (PAMORA) under development by Shionogi & Co., ... a phase III study (COMPOSE I) for the ... with chronic non-cancer pain receiving opioid therapy. Study ... once daily) statistically significantly improved the frequency of ...
(Date:3/29/2015)... Texas , March 29, 2015 /PRNewswire/ ... of study data in small cell cervical ... using Caris Molecular Intelligence®, the company,s panomic, ... certain gene mutations which may explain sensitivities ... found that identification of certain biomarkers may ...
(Date:3/27/2015)... The consumption of compound fertilizers (NPK) ... and high prices in 2008. However, the situation has ... on gaining momentum now. , To date, the world ... 100,000 thousand tonnes. No considerable growth was registered in ... rocketed during 2012-2013, registering 11% growth as against the ...
Breaking Biology Technology:Intrexon and Merck Serono Announce Agreement for the Development and Commercialization of CAR-T Therapy 2Intrexon and Merck Serono Announce Agreement for the Development and Commercialization of CAR-T Therapy 3Intrexon and Merck Serono Announce Agreement for the Development and Commercialization of CAR-T Therapy 4Shionogi & Co., Ltd. Announces That Naldemedine Meets Primary Endpoint In A Phase 3 Study For The Treatment Of Opioid-Induced Constipation 2Shionogi & Co., Ltd. Announces That Naldemedine Meets Primary Endpoint In A Phase 3 Study For The Treatment Of Opioid-Induced Constipation 3Study Using Caris Molecular Intelligence Multiplatform Tumor Profiling Identifies Potential Treatment Strategies for Small Cell Cervical Cancer 2Study Using Caris Molecular Intelligence Multiplatform Tumor Profiling Identifies Potential Treatment Strategies for Small Cell Cervical Cancer 3World NPK Fertilizers Market Keeps On Gaining Momentum, According to BAC Reports Study Available at MarketPublishers.com 2World NPK Fertilizers Market Keeps On Gaining Momentum, According to BAC Reports Study Available at MarketPublishers.com 3
... ThirdBiotech,( http://www.thirdbiotech.com ), a biotechnology networking ... in Arizona. (Logo: http://www.newscom.com/cgi-bin/prnh/20070911/LATU119LOGO ) ... the group to foster,networking and collaboration for ... the state. "It,s important we start finding ...
... 11 Dynatronics,Corporation (Nasdaq: DYNT ) will ... ended June 30, 2007 during the morning of ... conference call for investors later that,day at 1:00 ... quarter and fiscal year.,Those interested in participating should ...
... DALLAS, Sept. 11 ACCESS PHARMACEUTICALS, INC.,(OTC ... business columnist,Gene Marcial of BusinessWeek, highlighted Access ... 17, 2007. The article is also available,on ... Street, column. The article focused upon ...
Cached Biology Technology:Access Highlighted in Recent BusinessWeek Article 2
S-100 alpha/beta chain (8B10)...
SCCRO (S-17)...
... Blasticidin is a nucleoside ... It is a potent ... prokaryotic and eukaryotic cells. ... conferred by the products ...
... Mut S is a member of a ... integrity of the DNA sequence. Mut S plays ... in DNA ,replication, in transcription-coupled nucleotide excision repair ... of bacteria. Mut S binds to DNA specifically ...
Biology Products: