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Blocking the nerve receptor EP1 in mouse models reduces brain damage caused by stroke

713 works specifically at that receptor."

Finally, the Hopkins scientists showed that stimulation of EP1 receptors triggers the damage caused when blood flow is suddenly restored after a stroke. The team blocked blood flow in one of the main arteries feeding specific areas of the brain in mice lacking the gene for the EP1 receptor and then restored blood flow after 90 minutes. The area of brain damage (infarct size) in the mice lacking the EP1 gene was only about 57 percent of that seen in normal mice that underwent the same treatment. This provided additional evidence that brain damage caused by ischemia depends in large part on the stimulation of EP1 receptors, the researchers reported.

"Our results strongly suggest that given the side effects associated with COX inhibitors, we should focus our efforts on developing drugs that block the EP1 receptor instead of inhibiting COX-2 activity," said Doré.

Doré has applied for a patent covering the prevention and/or treatment of neurodegenerative diseases by administering agents that block the EP1 receptor.


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Source:Johns Hopkins Medical Institutions


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