Navigation Links
Blocking immune cell action increases Alzheimer's-associated protein deposits

affected by Alzheimer's, the receptor could be important for the movement of microglia to the site of amyloid-beta deposits. To test that possibility, the investigators used a mouse model of Alzheimer's disease and generated strains in which one or both copies of the CCR2 gene had been deleted.

They found that mice lacking CCR2 had significantly more amyloid-beta in their brains than did the Alzheimer's-model mice that retained the molecule. These deposits were primarily found in small blood vessels ?similar to a condition called cerebral amyloid angiopathy, which is associated with an increased risk of cerebral hemorrhage. In addition, CCR2-deficient mice had significantly shortened life spans. By 130 days of age, 85 percent of mice in which both copies of the CCR2 gene had been deleted had died, as had 60 percent of those with one copy. This compares with 30 percent of the Alzheimer's-model mice with two copies of CCR2 and only 1 percent of normal mice.

Analysis of levels of several enzymes known to either promote or break down amyloid-beta deposits revealed that a lack of CCR2 appears to reduce clearance of the toxic protein from the brain. Other tests suggest that CCR2 is required for microglia to migrate to sites of amyloid deposition but that its absence does not interfere with the cells' activity once they encounter amyloid-beta.

"By showing that microglia have a protective role in helping remove amyloid-beta from the brain, our findings suggest that enhancing the accumulation of these cells may be beneficial to patients with early-stage Alzheimer's disease," says Andrew Luster, MD, PhD, director of the MGH Center for Immunology and Inflammatory Diseases and senior author of the report.

The researchers also note that drugs that block CCR2 are currently being tested for chronic inflammatory diseases, and this study's results suggest that such agents could increase the risk of Alzheimer's in some individuals. L
'"/>

Source:Massachusetts General Hospital


Page: 1 2 3

Related biology news :

1. Blocking the nerve receptor EP1 in mouse models reduces brain damage caused by stroke
2. Fox Chase Cancer Center scientists identify immune-system mutation
3. Genetically modified natural killer immune cells attack, kill leukemia cells
4. Studies reveal methods viruses use to sidestep immune system
5. Jumping gene helps explain immune systems abilities
6. Scientists solve structure of key protein in innate immune response
7. Rats infected as newborns grew up vulnerable to memory problems during an immune challenge
8. NYU study reveals how brains immune system fights viral encephalitis
9. Chemists identify immune system mechanism for methamphetamine binges
10. Multi-purpose protein regulates new protein synthesis and immune cell development
11. Genetic defects give the immune system the green light to attack the pancreas
Post Your Comments:
(Date:8/27/2014)... The mechanical force that a single fungal cell or bacterial ... but it plays a heavy role in setting up some ... it may not be too much of a stretch to ... the ability to respond to the touch of beneficial fungi, ... professor of agronomy at the University of Wisconsin-Madison. , ...
(Date:8/27/2014)... Aug. 27, 2014  WaferGen Bio-systems, Inc. (NASDAQ: WGBS) ... underwritten public offering of units of common stock and ... gross proceeds of $20 million, prior to deducting underwriting ... Company.  The shares and warrants are immediately separable and ... sold in the offering consists of 2,000 shares of ...
(Date:8/27/2014)... of North America,s megafauna mastodons, short-faced bears, giant ... disappeared close to 13,000 years ago at the ... massive extinction has long been debated by scientists who, ... A group of scientists, including UC Santa Barbara,s James ... posited that a comet collision with Earth played a ...
Breaking Biology News(10 mins):A touching story: The ancient conversation between plants, fungi and bacteria 2A touching story: The ancient conversation between plants, fungi and bacteria 3WaferGen Bio-Systems Announces Successful Completion of Public Offering Raising $20 Million 2WaferGen Bio-Systems Announces Successful Completion of Public Offering Raising $20 Million 3Nanodiamonds are forever 2Nanodiamonds are forever 3
... expect to live slightly longer than Europeans. This has since ... now live about a year-and-a-half less, on average, than their ... other developed nations. How did Americans fall behind? A ... & Medicine is the first to calculate the fiscal ...
... shows the prevalence of gout in the U.S. has risen ... (4%) Americans. Prevalence of increased uric acid levels (hyperuricemia) also ... frequency of obesity and hypertension may be associated with the ... in Arthritis & Rheumatism , a journal published by ...
... east coast of Canada are showing signs of recovery more ... 1990s, according to research published today in Nature . ... an ecosystem that was pushed out of balance and that ... professor in the Department of Biology, former principal at Queen,s, ...
Cached Biology News:Getting 50-year-old Americans as healthy as Europeans could save Medicare and Medicaid $632 billion by 2050 2Gout prevalence swells in US over last 2 decades 2Cod resurgence in Canadian waters 2
(Date:8/27/2014)... August 27, 2014 Varian Medical Systems ... its current Salt Lake City manufacturing facility and allow ... Utah to ultimately create 1,000 new full time jobs ... , “Utah is home to hardworking people with immense ... credited with Varian’s success in the manufacturing of our ...
(Date:8/27/2014)... Green & Grow Inc. (GGI) has ... and secured Otter Capital as a significant new partner. ... of GGI’s Agriplier™ technology, building on recent compelling field ... our first meeting, we have been impressed with Otter ... said Alan Sobba, President and CEO of GGI. “We ...
(Date:8/27/2014)... -- Rhythm, a biopharmaceutical company developing peptide therapeutics that ... metabolic disorders, announced today that it has filed a ... and Exchange Commission (SEC) relating to the proposed initial ... number of shares to be offered and the price ... Citigroup and Cowen and Company will act ...
(Date:8/27/2014)... Livermore, California (PRWEB) August 27, 2014 ... (LLNL), through Lawrence Livermore National Security ... million to develop and deliver a state-of-the-art laser ... Beamlines facility (ELI Beamlines), under construction in the ... design performance, the laser system, called the " ...
Breaking Biology Technology:Varian Medical Systems Groundbreaking on Facility Expansion Triggers Influx of New Jobs to Salt Lake 2Varian Medical Systems Groundbreaking on Facility Expansion Triggers Influx of New Jobs to Salt Lake 3Green & Grow Inc. Secures $6M Series B Funding from Otter Capital 2Green & Grow Inc. Secures $6M Series B Funding from Otter Capital 3Rhythm Files Registration Statement for Proposed Initial Public Offering 2LLNL Synchs up with ELI Beamlines on Timing System 2LLNL Synchs up with ELI Beamlines on Timing System 3
... repairing damaged human tissue doesn,t wrinkle up when it ... of California, San Diego marks a significant breakthrough in ... of native human tissue. Shaochen Chen, professor ... Diego Jacobs School of Engineering, hopes future tissue patches, ...
... Mass., May 26, 2011 New England Biolabs (NEB), ... reagents for the life science industry, extends its global ... France, located at Bioparc Genopole in Evry, just south ... Ellard, President and CEO of NEB Inc., was on ...
... 2011 Addressing the issue of data overload from next-generation ... ) today launched its LifeScope™ 2.0 Genomic Analysis Software ... genomic sequencing instruments to study human disease such as cancer. ... A single next generation sequencing instrument can generate nearly 200 ...
Cached Biology Technology:Nanoengineers invent new biomaterial that more closely mimics human tissue 2New England Biolabs Opens New Subsidiary Office in France 2Life Technologies Simplifies, Organizes and Speeds Analysis of Genomic Data Through Launch of New LifeScope Bioinformatics Software 2Life Technologies Simplifies, Organizes and Speeds Analysis of Genomic Data Through Launch of New LifeScope Bioinformatics Software 3Life Technologies Simplifies, Organizes and Speeds Analysis of Genomic Data Through Launch of New LifeScope Bioinformatics Software 4Life Technologies Simplifies, Organizes and Speeds Analysis of Genomic Data Through Launch of New LifeScope Bioinformatics Software 5
This STAT antibody sampler pack contains 8 monoclonal ,STAT antibodies....
Kanamycin is used for selection of resistant bacteria. C18H36N4O11xH2SO4. Contains 10 mg/ml kanamycin (base) utilizing kanamycin sulfate in 0.85% saline....
...
...
Biology Products: