Navigation Links
Blame the brain for high blood pressure

The controversial idea that one cause of high blood pressure lies within the brain, and not the heart or blood vessels, has been put forward by scientists at the University of Bristol, UK, and is published this week in the journal Hypertension.

Dr. Hidefumi Waki, working in a research group led by Professor Julian Paton, has found a novel role for the protein, JAM-1 (junctional adhesion molecule-1), which is located in the walls of blood vessels in the brain.

JAM-1 traps white blood cells called leukocytes which, once trapped, can cause inflammation and may obstruct blood flow, resulting in poor oxygen supply to the brain. This has led to the idea that high blood pressure ?hypertension ? is an inflammatory vascular disease of the brain.

One in three people in the UK are likely to develop hypertension, and with 600 million people affected world wide, it is of pandemic proportions. The alarming statistic that nearly 60 per cent of patients remain hypertensive, even though they are taking drugs to alleviate the condition, emphasises the urgency of looking for new mechanisms by which the body controls blood pressure, and finding new therapeutic targets to drive fresh drug development.

Professor Paton said: “We are looking at the possibility of treating those patients that fail to respond to conventional therapy for hypertension with drugs that reduce blood vessel inflammation and increase blood flow within the brain. The future challenge will be to understand the type of inflammation within the vessels in the brain, so that we know what drug to use, and how to target them. JAM-1 could provide us with new clues as to how to deal with this disease. ?

Professor Jeremy Pearson, Associate Medical Director of the British Heart Foundation, commented: “This exciting study is important because it suggests there are unexpected causes of high blood pressure related to blood supply to the brain. It therefore opens up the possibility o
'"/>

Source:University of Bristol


Page: 1 2

Related biology news :

1. Getting old? Slowing down? Blame inefficient mitochondria
2. Controversial drug shown to act on brain protein to cut alcohol use
3. Mouse brain cells rapidly recover after Alzheimers plaques are cleared
4. Mouse brain tumors mimic those in human genetic disorder
5. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
6. First atlas of key brain genes could speed research on cancer, neurological diseases
7. NYU study reveals how brains immune system fights viral encephalitis
8. Stem cells from brain transformed to produce insulin at Stanford
9. Birds brains reveal source of songs
10. Loves all in the brain: fMRI study shows strong, lateralized reward, not sex, drive
11. Revolutionary nanotechnology illuminates brain cells at work
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Blame the brain for high blood pressure

(Date:9/17/2014)... learned a great deal about complex social behavior by ... something to teach too. , With their unusually large ... parrots live in a complex social environment---not merely in ... or ants, but in a dynamic setting of alliances ... intelligent mammals: dolphins, whales, primates, and social carnivores, like ...
(Date:9/16/2014)... the Columbia Center for Children,s Environmental Health at the ... demonstrate an association between childhood asthma and prenatal exposure ... household products. Results appear online in the journal ... mothers exposed during pregnancy to higher levels of the ... a 72 percent and 78 percent increase in risk ...
(Date:9/16/2014)... North American Menopause Society (NAMS) has published its ... midlife womenon everything from hot flashes to heart ... Society Recommendations for Clinical Care of Midlife Women," ... Menopause . This is the first, comprehensive ... midlife women freely available to all clinicians who ...
Breaking Biology News(10 mins):Being social: Learning from the behavior of birds 2Phthalates heighten risk for childhood asthma 2Phthalates heighten risk for childhood asthma 3
... the results of the Oats at 10 Years study, marking ... claim that oats, as part of an overall heart healthy ... written by Mark B. Andon, PhD, and James W. Anderson, ... claim, theorizing that foods containing whole-oat sources of soluble fiber ...
... University bioengineer Jennifer West is being recognized today with ... the O,Donnell Award from The Academy of Medicine, Engineering ... given for excellence in medical, scientific and engineering research, ... statue. West, a pioneer in the field of biomaterials ...
... of Alberta for those who may have overindulged during the recent ... a way to reduce the amount of bad cholesterol and fatty ... metabolizes, a key discovery that could lead to new drugs to ... disease related to obesity. In a series of recently ...
Cached Biology News:Rice's West honored as one of Texas' best researchers 2Rice's West honored as one of Texas' best researchers 3University of Alberta researchers report breakthrough in lowering bad cholesterol, fatty acid levels 2
(Date:9/17/2014)... BioClinica®, Inc., a leading provider of outsourced ... of its experts are speaking at the 20th ... be held September 28 to October 1 in ... announced the innovative Compass technology, a risk-based ... acquired earlier this year, is up for the ...
(Date:9/17/2014)... Intarcia Therapeutics, Inc. today announced ... of the cost and predictability of non-adherence in type ... Meeting of the European Association for the Study of ... Frois , Ph.D., of Analysis Group, Inc. presented data ... retrospective studies to characterize the prevalence of non-adherence and ...
(Date:9/17/2014)... - SQI Diagnostics Inc. (TSX-V: SQD) (OTCQX: SQIDF), a ... and products for advanced microarray diagnostics, today announced that ... the United States on the ... September 17, 2014 on the OTCQX under the symbol ... TSX Venture Exchange under its existing symbol SQD. ...
(Date:9/17/2014)... FOREST, California , 17 de septiembre ... CYRX) ("la compañía"), principal proveedor mundial de ... de las ciencias de la vida, anunció ... compañía de logística global con sede en ... su base de clientes Europa en rápido ...
Breaking Biology Technology:BioClinica to Present at 20th Annual SCDM Conference 2BioClinica to Present at 20th Annual SCDM Conference 3Intarcia Reveals New Insights At EASD Meeting Characterizing The Burden Of Poor Control And Non-Adherence To Anti-Diabetic Therapies 2Intarcia Reveals New Insights At EASD Meeting Characterizing The Burden Of Poor Control And Non-Adherence To Anti-Diabetic Therapies 3Intarcia Reveals New Insights At EASD Meeting Characterizing The Burden Of Poor Control And Non-Adherence To Anti-Diabetic Therapies 4Intarcia Reveals New Insights At EASD Meeting Characterizing The Burden Of Poor Control And Non-Adherence To Anti-Diabetic Therapies 5SQI Diagnostics to begin Trading on the OTCQX Marketplace in the United States 2SQI Diagnostics to begin Trading on the OTCQX Marketplace in the United States 3Cryoport contrata a Broekman Group para mejorar su apoyo operativo y logístico en Europa 2Cryoport contrata a Broekman Group para mejorar su apoyo operativo y logístico en Europa 3Cryoport contrata a Broekman Group para mejorar su apoyo operativo y logístico en Europa 4Cryoport contrata a Broekman Group para mejorar su apoyo operativo y logístico en Europa 5
... Calif., June 6 InterMune, Inc.,(Nasdaq: ITMN ) ... Financial Officer of InterMune, will present at the Goldman ... on,June 10, 2008 at 8:05 a.m. PDT (11:05 a.m. ... Needham & Company, LLC Biotechnology and,Medical Technology Conference in ...
... 5 BioTrends Research Group, Inc.,released its third ... management of psoriasis. This report is based on,responses ... Dermatologists in April,2008., According to the study, ... use of biologics for the treatment of psoriasis ...
... BioTrends Research Group, Inc. is,pleased to announce the ... is based on the results of an on-line ... France, Germany, Italy, and Spain.,The report focuses on ... In the ESA market, Amgen,s Aranesp is ...
Cached Biology Technology:InterMune to Present at Goldman Sachs Healthcare and Needham & Co. Biotechnology and Medical Technology Conferences 2Dermatologists Report Increased Use of Biologics in the Treatment of Psoriasis 2New Study by BioTrends Highlights Practice Management Shifts Among European Nephrologists 2