Navigation Links
Bird flu vaccine additive may stretch supply

Researchers have achieved an effective immune response to an avian influenza vaccine with doses as low as one-quarter of the norm when they added a chemical mixture known as MF59. The research is published in the November 1 issue of Clinical Infectious Diseases, now available online.

MF 59 is an adjuvant--a substance that increases the immune system's ability to respond to a stimulus. For this research, the investigators used inactivated H9N2 influenza vaccines--not the H5N1 virus currently feared as a potential pandemic strain. However, the study does suggest that if the feared pandemic comes to be, adjuvants might be used to extend the vaccine supply. Furthermore, the authors note, H9N2 is itself a pandemic threat.

The researchers vaccinated 96 young adults who were divided into eight groups receiving different dosage levels, half of the groups with and half without the MF59 adjuvant. The volunteers were tested for antibodies at 28 days and 56 days.

"Antibody in the blood to the influenza virus that you're trying to protect against is what protects people from getting the flu," said Robert Atmar, MD, lead author of the study. "What vaccines do is cause the vaccinated person to produce antibodies in their bloodstream. The higher the antibody levels, in general, the more likely people are to be protected from getting ill or from getting infected at all.

"What we found was that when the adjuvant material was included in the vaccine--at all dosage levels--the antibody response was significantly better, and as low as one-quarter the dose worked very well. And a single dose of the adjuvanted vaccine was as good as two doses of the vaccine without the adjuvant." This suggests that adjuvants might be used to stretch a limited vaccine supply and allow vaccination of greater numbers of people.

Neither group experienced serious reactions to the vaccines. However, mild pain or swelling was more common in the adjuvant group.
'"/>

Source:Infectious Diseases Society of America


Page: 1

Related biology news :

1. Research advances quest for HIV-1 vaccine
2. A much-needed shot in the arm for HIV vaccine development
3. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
4. Gene vaccine for Alzheimers disease shows promising results
5. Influenza vaccine uses insect cells to speed development
6. Norovirus, AIDS vaccine and Hepatitis Virus
7. HIV vaccine trial breaks ground for future research
8. Live vaccines more effective against horse herpes virus
9. NIAID begins clinical trial of West Nile virus vaccine
10. Designing vaccines by computer
11. Wake Forest scientists find new combination vaccine effective against plague
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/22/2017)... VILNIUS, Lithuania , March 21, 2017 /PRNewswire/ ... identification and object recognition technologies, today announced the ... development kit (SDK), which provides improved facial recognition ... safety cameras on a single computer. The new ... algorithms to improve accuracy, and it utilizes a ...
(Date:3/16/2017)... March 16, 2017 CeBIT 2017 - Against identity fraud with DERMALOG ... ... Used combined in one project, multi-biometric solutions provide a crucial contribution ... Used combined in one ... ...
(Date:3/7/2017)... 2017   HireVue , the leading provider of ... the best talent, faster, today announced the additions of ... and Diana Kucer as Chief Marketing Officer ... team poised to drive continued growth in the company,s ... of record bookings in 2017. "Companies worldwide ...
Breaking Biology News(10 mins):
(Date:3/30/2017)... 2017 In today,s pre-market research, ... Intrexon Corp. (NYSE: XON), Progenics Pharmaceuticals Inc. (NASDAQ: PGNX), ... According an article on Barron,s, Credit Suisse upgraded its rating ... March 21 st , 2017. These stocks research reports can ... ...
(Date:3/29/2017)... 29, 2017  Vermillion, Inc. (NASDAQ: VRML), a ... on its results for the fourth quarter and ... "2016 marked a pivotal year for us with ... international distribution agreements, major reimbursement progress with Medicare, ... agreements. In addition we cleared our 2 nd ...
(Date:3/29/2017)... TIKVAH, Israel , March ... (NASDAQ: BCLI), a leading developer of adult ... financial results for the year ended December ... highly successful and pivotal year for Brainstorm, with a ... made on clinical, regulatory and operational fronts," said ...
(Date:3/29/2017)... ... March 29, 2017 , ... On the heels of the ... Colpitts Clinical Trial Travel has announced that it will manage travel services for its ... the first in the United States and Europe to offer travel management services specifically ...
Breaking Biology Technology: