Navigation Links
Bird flu vaccine additive may stretch supply

Researchers have achieved an effective immune response to an avian influenza vaccine with doses as low as one-quarter of the norm when they added a chemical mixture known as MF59. The research is published in the November 1 issue of Clinical Infectious Diseases, now available online.

MF 59 is an adjuvant--a substance that increases the immune system's ability to respond to a stimulus. For this research, the investigators used inactivated H9N2 influenza vaccines--not the H5N1 virus currently feared as a potential pandemic strain. However, the study does suggest that if the feared pandemic comes to be, adjuvants might be used to extend the vaccine supply. Furthermore, the authors note, H9N2 is itself a pandemic threat.

The researchers vaccinated 96 young adults who were divided into eight groups receiving different dosage levels, half of the groups with and half without the MF59 adjuvant. The volunteers were tested for antibodies at 28 days and 56 days.

"Antibody in the blood to the influenza virus that you're trying to protect against is what protects people from getting the flu," said Robert Atmar, MD, lead author of the study. "What vaccines do is cause the vaccinated person to produce antibodies in their bloodstream. The higher the antibody levels, in general, the more likely people are to be protected from getting ill or from getting infected at all.

"What we found was that when the adjuvant material was included in the vaccine--at all dosage levels--the antibody response was significantly better, and as low as one-quarter the dose worked very well. And a single dose of the adjuvanted vaccine was as good as two doses of the vaccine without the adjuvant." This suggests that adjuvants might be used to stretch a limited vaccine supply and allow vaccination of greater numbers of people.

Neither group experienced serious reactions to the vaccines. However, mild pain or swelling was more common in the adjuvant group.
'"/>

Source:Infectious Diseases Society of America


Page: 1

Related biology news :

1. Research advances quest for HIV-1 vaccine
2. A much-needed shot in the arm for HIV vaccine development
3. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
4. Gene vaccine for Alzheimers disease shows promising results
5. Influenza vaccine uses insect cells to speed development
6. Norovirus, AIDS vaccine and Hepatitis Virus
7. HIV vaccine trial breaks ground for future research
8. Live vaccines more effective against horse herpes virus
9. NIAID begins clinical trial of West Nile virus vaccine
10. Designing vaccines by computer
11. Wake Forest scientists find new combination vaccine effective against plague
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Bird flu vaccine additive may stretch supply

(Date:7/31/2014)... the United States, natural-gas production from shale rock ... 2007. Yet scientists still do not fully understand ... to a report in the journal Frontiers ... gas extraction continues to vastly outpace scientific examination, ... organizations and institutions, including Princeton University, concluded that ...
(Date:7/31/2014)... Foundation (NSF), counters a widely-held scientific view that ... that certain Arctic lakes store more greenhouse gases ... The study, published this week in the journal ... occur as permafrost thaws and creates surface depressions ... was previously frozen land into lakes. , The ...
(Date:7/31/2014)... long been known that biomass burning burning ... a ritual , slash-and-burn agriculture and wildfires ... , But until the release of a new ... Professor Mark Z. Jacobson, the degree of that ... research, detailed in a paper published July 30 ...
Breaking Biology News(10 mins):'Fracking' in the dark: Biological fallout of shale-gas production still largely unknown 2'Fracking' in the dark: Biological fallout of shale-gas production still largely unknown 3Certain Arctic lakes store more greenhouse gases than they release 2Stanford professor finds that wildfires and other burns play bigger role in climate change 2Stanford professor finds that wildfires and other burns play bigger role in climate change 3Stanford professor finds that wildfires and other burns play bigger role in climate change 4
... kid goats recognise each other,s calls soon after the mothers ... reveals. The study, published in the journal Animal ... the ability of goats to recognise the individual differences. ... Mary,s School of Biological and Chemical Sciences found that mother ...
... smoke flavoring made from hickory and other wood a ... and home kitchens may get a competitor that seems ... to a new study in ACS, Journal of Agricultural ... liquid smoke produced from rice hulls, the hard, inedible coverings ...
... For diagnosing head and neck ailments, tests that ... don,t. Otolaryngologists have a wide range of techniques available ... ultrasound. CT uses significant radiation and MRI a lower ... does not require injection of radioactive contrast material and ...
Cached Biology News:Lessening the dangers of radiation 2
(Date:7/31/2014)... Texas (PRWEB) August 01, 2014 ... and China Polyurethane Resin Industry” is a ... Resin market. The report introduces Polyurethane Resin ... and industry chain structure and industry overview. ... including China’s domestic market as well as ...
(Date:7/31/2014)... a good reason people over 60 are not donor ... and weakens with time, making the elderly prone to ... Francisco research team now has discovered a reason why. ... the inability of blood-forming cells to maintain blood production ... molecular defects that could be restored for rejuvenation therapies," ...
(Date:7/31/2014)... Johns Hopkins have mapped the sound-processing part of the ... proverbial forest and the trees in view. Their imaging ... brain activity within mice, and it enabled the team ... to each other. The results, which represent a step ... appear online July 31 the journal Neuron . ...
(Date:7/31/2014)... 2014 According to a new ... Market - Global Industry Analysis, Size, Share, Growth, Trends ... at USD 88.5 million in 2011, which is expected ... a CAGR of 53.8% from 2013 to 2023. ... http://www.transparencymarketresearch.com/quantum-dots.html Increasing demand for energy efficient ...
Breaking Biology Technology:Polyurethane Resin Industry & Thermoplastic Polyurethane Market (China, Global) Analysis Now at DeepResearchReports.com 2Polyurethane Resin Industry & Thermoplastic Polyurethane Market (China, Global) Analysis Now at DeepResearchReports.com 3Polyurethane Resin Industry & Thermoplastic Polyurethane Market (China, Global) Analysis Now at DeepResearchReports.com 4Key to aging immune system is discovered 2New mapping approach lets scientists zoom in and out as the brain processes sound 2Global Quantum Dots Market is Expected to Reach USD 8,246.8 Million in 2023: Transparency Market Research 2Global Quantum Dots Market is Expected to Reach USD 8,246.8 Million in 2023: Transparency Market Research 3Global Quantum Dots Market is Expected to Reach USD 8,246.8 Million in 2023: Transparency Market Research 4
... PITTSBURGH, Sept. 23 As the world converges on Pittsburgh ... are clear skies and the lack of the traditional, stereotypical ... they are greeted by a region that for the past ... to a service economy centered on the development and commercialization ...
... , , , ... the "Company") (OTC Bulletin Board: GLOB), an international healthcare information technology ... intent with verIDentia SL of Macanet De La Selva, Girona, ... were not disclosed. , , (Logo: http://www.newscom.com/cgi-bin/prnh/20040226/GLOBALMEDLOGO ...
... Biological Sciences Research Council (BBSRC) have uncovered what happens ... found that the important proteins that make up the ... enzyme called cathepsin L. Scientists now have to take ... ensure the exciting field of nanomedicine can progress. The ...
Cached Biology Technology:Pittsburgh Life Sciences Greenhouse Demonstrates a Region's Economic Resilience 2Pittsburgh Life Sciences Greenhouse Demonstrates a Region's Economic Resilience 3Global Med Technologies(R) Signs Binding LOI With European Company for Breakthrough Transfusion Safety RFID Product 2Global Med Technologies(R) Signs Binding LOI With European Company for Breakthrough Transfusion Safety RFID Product 3Global Med Technologies(R) Signs Binding LOI With European Company for Breakthrough Transfusion Safety RFID Product 4Global Med Technologies(R) Signs Binding LOI With European Company for Breakthrough Transfusion Safety RFID Product 5New discovery reveals fate of nanoparticles in human cells 2
... Express Cloning Checker Kits provide two ... after transformation without time-consuming plasmid preparation. By ... I, all you need to do is ... bacteria directly from the transformation plates into ...
... Services include subcloning of gene in ... cells, isolation and plaque purification of ... virus stock for one clone, protein ... insect cell culture. Expected yield and ...
Request Info...
Kit containing positive control DNA all parts of the HIV-1 genome, HIV-1 negative control DNA, Primers SK38, SK39, SK19...
Biology Products: