Navigation Links
Biota makes major antiviral discovery

Biota Holdings Limited announced today that it has discovered a new class of orally-effective, potent antivirals against RSV (respiratory syncytial virus) infection. Biota has filed worldwide patents and selected a lead candidate with a series of backups for further preclinical development prior to human clinical trials.

RSV infection is an important medical need and already a billion-dollar market, with growing visibility among pharmaceutical companies. The currently marketed drug is an injectable antibody with 2004 sales of approximately US$1 billion ($1.3 billion). However, its use is limited to prevention of infection, not treatment, and it is currently only approved for use in the highest risk group of patients: premature infants. If successful, the Biota RSV drug is expected to have significant advantages and could expand the market to include treatment as well as prevention and to other 'at risk' patient segments, such as children, the elderly and people with underlying respiratory conditions.

Latest results in two animal models also demonstrate that Biota's new RSV antivirals are effective when administered orally. This should allow the product to be developed in a convenient oral formulation, such as a tablet or suspension.

"The discovery of a novel, orally available RSV antiviral is a major achievement," said Dr Simon Tucker, Vice President of Research for Biota. "Others, including several large pharmaceutical companies, have discovered and disclosed RSV antivirals, but many are inhaled products. Orally effective RSV compounds appear to be a rarity. This is an exciting achievement for Biota and Australian research."

The current compounds are the result of research conducted by the Biota team over several years. Since 2003, this research has been supported by a $2.7m R&D Start grant from the Australian government. The RSV development follows on the heels of the company's recent decision to advance its common cold (human rh
'"/>

Source:Biota


Page: 1 2

Related biology news :

1. University of Manchester makes made-to-measure skin and bones a reality using inkjet printers
2. Grass makes environmentally friendly biofuel
3. Shampoo detergent added to paint makes surfaces self-sterilizing
4. Green diesel: New process makes liquid transportation fuel from plants
5. Discovery that bacterium is phosphate gourmet key clue to what makes it most social of bacteria
6. Technique makes it easier to see mouse embryo in all its glory
7. In the minds eye: How the brain makes a whole out of parts
8. African parasite makes component of fat differently from all other organisms
9. Coffee makes us more likely to say yes
10. Eat less, weigh more? Enzyme makes lean mice susceptible to dietary fat
11. Embryonic patterning makes the feathers fly
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Biota makes major antiviral discovery

(Date:8/19/2014)... study that analyzed concentrations of African dust transported ... winter and spring. These research findings offer new ... quality impacts of African dust, including the climate ... occur from increased African dust emissions in the ... (UM) Rosenstiel School of Marine and Atmospheric Science ...
(Date:8/19/2014)... already exist in different forms, they have not been ... production. Now researchers from the University of Surrey and ... common elastic bands with graphene, to create a flexible ... can be made cheaply. , Once treated, the ... with graphene - which imparts an electromechanical response on ...
(Date:8/18/2014)... a person,s gut may protect against or increase susceptibility ... human bacterial intestinal inflammation, according research published this week ... the American Society for Microbiology. The study also found ... to one,s gut bacteria composition. , "It has been ... microorganisms in the gut, can protect a person from ...
Breaking Biology News(10 mins):Study of African dust transport to South America reveals air quality impacts 2What's in your gut? Certain bacteria may influence susceptibility to infection 2
... German . , FRANKFURT. Iron containing short nerve ... a magnetometer to measure the vector of the Earth magnetic ... compass, which shows the direction of the magnetic field lines. ... her husband Prof. Dr. Gnther Fleissner have discovered these structures ...
... sent to evaluate damage from the devastating magnitude-7 earthquake ... evidence of the fault that might have caused the ... help pinpoint the epicenter. , University of Washington civil ... that provided engineering support to the United States Southern ...
... terrain ranging from endless chains of mountains and isolated ... magma and other minerals from below Earth,s surface. This ... and the marine life it supports, is the spotlight ... Oceanography . These massive underwater mountains, or seamounts, ...
Cached Biology News:A magnetometer in the upper beak of birds? 2A magnetometer in the upper beak of birds? 3Earthquake engineers release report on damage in Haiti 2Earthquake engineers release report on damage in Haiti 3Seamounts reach a pinnacle in upcoming issue of Oceanography 2
(Date:8/19/2014)... 19, 2014 CSSi, the leader in patient ... the formation of the company,s Medical and Clinical Advisory ... of Dr. William E. Gannon, Jr. to ... The MCAB, with Dr. Gannon,s leadership, ... areas and set strategic goals for the advancement and ...
(Date:8/19/2014)... 19, 2014   Synthetic Biologics, Inc. ... anti-infective biologic and drug programs targeting specific pathogens ... that its novel C. difficile development ... Interscience Conference on Antimicrobial Agents and Chemotherapy ... Synthetic Biologics, Senior Vice ...
(Date:8/19/2014)... Sales Horizons, a leader in sales training, today ... training course to help companies develop clinical staff ... the majority of their time on client sites – ... practice – providing support and education to both clinical ... believes clinical staff are and should be considered an ...
(Date:8/18/2014)... FL (Aug. 18, 2014) -- A new therapy ... Florida (USF) Morsani College of Medicine and Columbia ... life-threatening complications of interventional cardiovascular disease treatment. ... that the novel molecular therapy could selectively inhibit ... following a medical procedure using a balloon catheter ...
Breaking Biology Technology:CSSi Appoints Dr. William E. Gannon, Jr. to Newly Formed Medical and Clinical Advisory Board 2CSSi Appoints Dr. William E. Gannon, Jr. to Newly Formed Medical and Clinical Advisory Board 3Synthetic Biologics Announces Late-Breaking Poster Presentation for C. difficile Program at 54th ICAAC 2Synthetic Biologics Announces Late-Breaking Poster Presentation for C. difficile Program at 54th ICAAC 3Synthetic Biologics Announces Late-Breaking Poster Presentation for C. difficile Program at 54th ICAAC 4Sales Horizons Launches a New Online Sales Training Course for MedTech Clinical Staff to Develop Their Sales Skills 2Sales Horizons Launches a New Online Sales Training Course for MedTech Clinical Staff to Develop Their Sales Skills 3Selective therapy may improve artery repair after interventional cardiovascular procedures 2Selective therapy may improve artery repair after interventional cardiovascular procedures 3
... question asked by state legislators who must pass judgment on ... it?" The second is, "How will it help Wisconsin ... Wisconsin Institute for Discovery is providing some straightforward, and exciting, ... on the UW-Madison campus with half public money and half ...
... in decidedly unromantic spots like little beige offices and ... equity firm Mason Wells , he is the ... its IT venture capital to unknown startups with huge ... events such as the recent Fusion CEO-CIO Symposium ...
... Mozilla Foundation, is offering beleagured e-mail users an alternative, ... of Firefox, the open-source Web browser whose launch included ... the open-source e-mail program Thunderbird reached its 1.0 version ... that makes it easy to focus on mail. ...
Cached Biology Technology:How the Institute for Discovery will help Wisconsin 2How the Institute for Discovery will help Wisconsin 3Successful Wisconsin VC sets sights on data integration and mass storage 2Successful Wisconsin VC sets sights on data integration and mass storage 3Google and Mozilla e-mail apps offer more space, escape from viruses 2Google and Mozilla e-mail apps offer more space, escape from viruses 3
Goat polyclonal to MLH3 Immunogen: Synthetic peptide: RQSLQQSMPPCEPP (Human) from C Terminus of the protein sequence according to NP_055196....
IRF7 Immunogen: Synthetic peptide corresponding to residues E(463) G T Q R E G V S S L D S S S(477) of human IRF7. Storage: -20 C, Avoid Freeze/Thaw Cycles...
Rabbit polyclonal to NMDAR1 e/f/g/h ( Abpromise for all tested applications)....
Rabbit polyclonal to TetR ( Abpromise for all tested applications). Antigen: Synthetic peptide: AQKLGVEQPTLYWHVKNKR, corresponding to amino acids 31 - 49 of TetR...
Biology Products: