Navigation Links
Biomarkers isolated from saliva successfully predict oral and breast cancer

Screening for breast cancer and the early detection of other tumors one day may be as simple as spitting into a collection tube or cup, according to recent studies by UCLA researchers.

In one early study based on a risk model, presented here at the 96th Annual Meeting of the American Association for Cancer Research, the UCLA scientists reported that genetic "biomarkers" isolated in saliva predicted oral squamous cell carcinoma in about nine out of 10 cases.

A recent study by this group, published in Clinical Cancer Research, disclosed similar predictive powers for head and neck cancers.

"These results indicate that such biomarkers found in saliva, called salivary transcriptomes, can be exploited for robust, high-throughput and reproducible tools for early disease detection," said David T. Wong, professor and associate dean of research at the UCLA School of Dentistry and the Jonsson Comprehensive Cancer Center, the study's senior investigator.

"This is a proof-of-principal study, but our results will need to be validated in a larger sample size in a blinded manner," he added.

Also participating in the study were Yang Li, David Elashoff, MyungShin Oh, Stephanie Tsung, and Mai N. Brooks at UCLA.

Harvesting saliva and other bodily fluids for molecules that detect early cancers has long been a goal of scientists seeking quick and easy screening tools that could be done in a doctor's office. The search for such tests, however, has been stalled until recently with the advance of several emerging technologies including improved methods to identify, collect, preserve and amplify genetic material and proteins.

In this study, the UCLA team found they could isolate messenger RNA from saliva and blood sera that might have diagnostic value for detecting early cancer. In the cell, messenger RNA or mRNA carries a copy of the genetic code or DNA, housed in the cell's nucleus, to other parts of the cell for protein manufacture. T
'"/>

Source:American Association for Cancer Research


Page: 1 2

Related biology news :

1. Measurement Challenges In Detecting Cancer Biomarkers
2. Biomarkers may hone anti-aging therapies
3. New peptide antibiotic isolated from American oyster
4. New, automated tool successfully classifies and relates proteins in unprecedented way
5. UN successfully tests green pesticide against locusts
6. Stem cell therapy successfully treats heart attack in animals
7. Mad cow proteins successfully detected in blood
8. Israeli scientists successfully transplant frozen-thawed ovaries in sheep
9. Magnetic probe successfully tracks implanted cells in cancer patients
10. Study identifies predictors of HIV drug resistance in patients beginning triple therapy
11. Multiple-drug resistant gene expression pattern predicts treatment outcome for pediatric leukemia
Post Your Comments:
(Date:8/28/2014)... of new roads will be built worldwide by 2050. ... wildernesses, where they bring an influx of destructive loggers, ... study has created a ,global roadmap, for prioritising road ... competing demands of development and environmental protection. , The ... that natural importance of ecosystems and a ,road-benefits, layer ...
(Date:8/28/2014)... the world to Global Warming, has called for atmospheric ... He says that Carbon Capture, combined with limits on ... global warming getting out of control over the next ... the call during his presentation to the International Carbon ... to discuss Carbon Capture and Storage. , He ...
(Date:8/28/2014)... assigned a number of 435-million-year-old fossils to a ... in shallow marine habitats and were far less ... , Before they sank to the bottom ... some 435 million years ago, these arthropods preyed ... although they were not exactly inconspicuous, possessing a ...
Breaking Biology News(10 mins):Study shows where on the planet new roads should and should not go 2Study shows where on the planet new roads should and should not go 3Global warming pioneer calls for CO2 to be taken from atmosphere and stored underground 2Paleontology: Oldest representative of a weird arthropod group 2
... is poised to become the first example of a ... a major threat to endangered wildlife that authorities are ... found only in Iran, is considered Critically Endangered and ... individuals. The amphibian is being proposed for an Appendix ...
... Boston, Mass. -- A large study from Children,s Hospital Boston ... that samples the entire genome, known as chromosomal microarray analysis, ... related to autism spectrum disorders (ASDs) than standard tests. Publishing ... March 15), the authors urge that CMA become part of ...
... March 10, 2010 Using a novel light activation technique, ... with only a modest ability to fight specific proteins into ... "warhead" molecule capable of inactivating nearby proteins when triggered by ... by providing researchers with a new set of research tools ...
Cached Biology News:Potential CITES trade ban for rare salamander underscores wildlife e-commerce 2A better genetic test for autism 2A better genetic test for autism 3Light activated 'warhead' turns modest molecules into super protein killers 2Light activated 'warhead' turns modest molecules into super protein killers 3
(Date:8/28/2014)... “This kit has an improved extraction efficiency and ... 150 ppb,” said Mark Tess, PhD, Mycotoxin Product Manager for ... owners and USDA-GIPSA inspection agencies that have a need to ... place in a matter of minutes with nothing but our ... feed and grain before accepting it, but they no longer ...
(Date:8/28/2014)... month, executives from clinical trial marketing firm BBK Worldwide will ... Patient-Centered Clinical Trials 2014 , to be held at the ... 4-5. Patient recruitment experts Bonnie A. Brescia , ... insights on the benefits of employing an effective patient engagement ... to mobile apps – can be used to drive study ...
(Date:8/28/2014)... (PRWEB) August 27, 2014 Scientists, researchers, ... for SPIE Laser Damage 2014 symposium. Marking ... for high-power lasers will run 14-17 September. The event ... optics and photonics . , The premier conference for ... laser damage to optical materials will engage researchers and ...
(Date:8/28/2014)... Whitehouse Laboratories is excited to announce ... PTI Inspection Systems that will enable it ... art leak testing method development and validation programs using ... As part of this agreement, Whitehouse Labs has taken ... Instrument developed and manufactured by PTI. The HVLD ...
Breaking Biology Technology:BBK Worldwide Leads Sessions at Key September Events 2Laser Damage to Draw Researchers, Engineers, Scientists to 46th Annual Conference 2Laser Damage to Draw Researchers, Engineers, Scientists to 46th Annual Conference 3Whitehouse Labs Renews Partnership with PTI Inspection Systems 2Whitehouse Labs Renews Partnership with PTI Inspection Systems 3
... FRANCISCO, Calif., Dec. 8 Rigel,Pharmaceuticals, Inc. (Nasdaq: ... chief executive officer, will participate in a panel,discussion at the ... and Targets for Inflammation and Rheumatology", will take,place on Wednesday, ... Times,Square Hotel in New York City. , ...
... MINNEAPOLIS, Dec. 8 ATS Medical, Inc.,(Nasdaq: ATSI ... today announced it has received FDA clearance for the,marketing of ... tab,material supplier and an improved valve holder accessory device. , ... ) , While the ...
... When it comes to the world of the very, very ... and its capacity to alter the fundamentals of nature, it ... In a report published today (Dec. 7) in the journal ... and Europe reveal a sharp contrast in the perception that ...
Cached Biology Technology:ATS Medical Provides Update on US Commercialization of Its ATS 3f Aortic Bioprosthesis 2ATS Medical Provides Update on US Commercialization of Its ATS 3f Aortic Bioprosthesis 3For nano, religion in US dictates a wary view 2For nano, religion in US dictates a wary view 3
Mouse anti-IkBa/MAD-3 Class: Antibody Product Group: Signalling molecules and phospho-specific Antibody...
Rabbit polyclonal to Oct2, prediluted ( Abpromise for all tested applications). entrezGeneID: 5452 SwissProtID: P09086...
Anti-Mouse Reticular Fibroblast, Purified (Clone ER-TR7) (rat IgG2a)...
Mouse monoclonal [2Q2147] to Aequorin ( Abpromise for all tested applications)....
Biology Products: