Navigation Links
Biomarkers isolated from saliva successfully predict oral and breast cancer

Screening for breast cancer and the early detection of other tumors one day may be as simple as spitting into a collection tube or cup, according to recent studies by UCLA researchers.

In one early study based on a risk model, presented here at the 96th Annual Meeting of the American Association for Cancer Research, the UCLA scientists reported that genetic "biomarkers" isolated in saliva predicted oral squamous cell carcinoma in about nine out of 10 cases.

A recent study by this group, published in Clinical Cancer Research, disclosed similar predictive powers for head and neck cancers.

"These results indicate that such biomarkers found in saliva, called salivary transcriptomes, can be exploited for robust, high-throughput and reproducible tools for early disease detection," said David T. Wong, professor and associate dean of research at the UCLA School of Dentistry and the Jonsson Comprehensive Cancer Center, the study's senior investigator.

"This is a proof-of-principal study, but our results will need to be validated in a larger sample size in a blinded manner," he added.

Also participating in the study were Yang Li, David Elashoff, MyungShin Oh, Stephanie Tsung, and Mai N. Brooks at UCLA.

Harvesting saliva and other bodily fluids for molecules that detect early cancers has long been a goal of scientists seeking quick and easy screening tools that could be done in a doctor's office. The search for such tests, however, has been stalled until recently with the advance of several emerging technologies including improved methods to identify, collect, preserve and amplify genetic material and proteins.

In this study, the UCLA team found they could isolate messenger RNA from saliva and blood sera that might have diagnostic value for detecting early cancer. In the cell, messenger RNA or mRNA carries a copy of the genetic code or DNA, housed in the cell's nucleus, to other parts of the cell for protein manufacture. T
'"/>

Source:American Association for Cancer Research


Page: 1 2

Related biology news :

1. Measurement Challenges In Detecting Cancer Biomarkers
2. Biomarkers may hone anti-aging therapies
3. New peptide antibiotic isolated from American oyster
4. New, automated tool successfully classifies and relates proteins in unprecedented way
5. UN successfully tests green pesticide against locusts
6. Stem cell therapy successfully treats heart attack in animals
7. Mad cow proteins successfully detected in blood
8. Israeli scientists successfully transplant frozen-thawed ovaries in sheep
9. Magnetic probe successfully tracks implanted cells in cancer patients
10. Study identifies predictors of HIV drug resistance in patients beginning triple therapy
11. Multiple-drug resistant gene expression pattern predicts treatment outcome for pediatric leukemia
Post Your Comments:
(Date:11/21/2014)... Nov. 20, 2014   Atmel® Corporation (NASDAQ: ... (MCU) and touch technology solutions, today launched the industry,s ... with the widest V cc range from 1.7V ... and faster I 2 C bus communication speeds, and ... memory making them ideal for consumer, industrial, computer, and ...
(Date:11/18/2014)... , Nov. 17, 2014   ... EMC collaborate to develop The Partners Data Lake, ... The Partners Data Lake will allow researcher and ... diagnostics, treatment and the lives of patients ... and clinical activities across the Partners system, breaking ...
(Date:11/18/2014)... , Nov. 18, 2014   EyeLock Inc. ... solutions, and MorphoTrust USA (Safran), a ... today announced a strategic partnership to offer comprehensive ... vehicle administration (MVA), airport screening and financial services ... solutions, MorphoTrust serves consumers through a nationwide network ...
Breaking Biology News(10 mins):Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 2Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 3Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 2Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 3Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 5EyeLock, MorphoTrust Form Strategic Partnership to Pursue Commercial Enterprise Deployments 2EyeLock, MorphoTrust Form Strategic Partnership to Pursue Commercial Enterprise Deployments 3
... led by Simon Fraser University,s Gerontology Research Centre (GRC) ... (SEI) is tracking attitudes about the environment among those ... of organizations, will provide a snapshot of current attitudes ... change. The survey aims to identify difficulties ...
... of meanings. Fluid flow in the human body is ... and pathogens that travel through the air. In fact, ... plethora of biological activities. Even the motions of a basketball ... a dynamical system. For the past eight years, ...
... have already been introduced into the wild on a ... release of genetically modified animals is still at a ... Max Planck Institute for Evolutionary Biology in Pln, Germany ... of genetically modified insects in Malaysia, USA, and Cayman ...
Cached Biology News:Survey tracks '55+' attitudes about the environment 2Shane Ross garners CAREER Award to advance understanding of fluid flows from blood inside the body to oil spills in bodies of water 2Shane Ross garners CAREER Award to advance understanding of fluid flows from blood inside the body to oil spills in bodies of water 3Transgene insects: Scientists call for more open data 2Transgene insects: Scientists call for more open data 3Transgene insects: Scientists call for more open data 4
(Date:12/17/2014)... 17, 2014 Gene synthesis and ... has entered into a technology access and services ... apply DNA2.0’s proprietary protein engineering technology, known as ... “We are extremely excited that the global leader ... This proprietary bioengineering technology has now been validated ...
(Date:12/17/2014)... -- CASI Pharmaceuticals, Inc. (Nasdaq: CASI ), ... commercialization of innovative therapeutics addressing cancer and other unmet ... commercial focus on China , today ... meeting with the U.S. Food and Drug Administration (FDA) ... 2015.  During this meeting the Company will seek guidance ...
(Date:12/15/2014)... Israel , Dec. 15, 2014  BrainStorm ... leading developer of adult stem cell technologies for neurodegenerative ... Ltd. was awarded a grant of approximately $1.1 million ... Chief Scientist (OCS).  This is the eighth year that ... the Office of the Chief Scientist, which is part ...
(Date:12/15/2014)... , Dec. 15, 2014  Ascendis Pharma ... TransCon technology to address significant unmet medical needs, ... ongoing Phase 2 pediatric study to evaluate once-weekly ... deficiency, or GHD.  This interim analysis consists of ... total enrollment in the study, completing all six ...
Breaking Biology Technology:ADM and DNA2.0 Enter Into Protein Engineering Technology Access and Service Agreement 2CASI Pharmaceuticals Granted Type C Meeting With U.S. FDA For ENMD-2076 In Fibrolamellar Carcinoma 2CASI Pharmaceuticals Granted Type C Meeting With U.S. FDA For ENMD-2076 In Fibrolamellar Carcinoma 3CASI Pharmaceuticals Granted Type C Meeting With U.S. FDA For ENMD-2076 In Fibrolamellar Carcinoma 4CASI Pharmaceuticals Granted Type C Meeting With U.S. FDA For ENMD-2076 In Fibrolamellar Carcinoma 5BrainStorm Receives $1,100,000 for its 8th Annual Non-Dilutive Grant from Israel's Chief Scientist Office 2BrainStorm Receives $1,100,000 for its 8th Annual Non-Dilutive Grant from Israel's Chief Scientist Office 3Ascendis Pharma A/S Announces Positive Six-Month Interim Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 2Ascendis Pharma A/S Announces Positive Six-Month Interim Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 3Ascendis Pharma A/S Announces Positive Six-Month Interim Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 4
... , , , ... now offers new larger pack sizes,of PCR-Grade Nucleotides. These larger pack sizes,combine the best available quality ... , , Single dNTPs , ... Single dNTPs are now available in 500-mol pack sizes.,The Deoxynucleoside Triphosphate Set, containing all four ...
... , , ... , , , With the introduction of ... the robust amplification of fragments up to,3 kb, providing the highest possible fidelity ... , , , Pwo Master is a ...
... , ... , , , ... for the detection and quantitation,of mRNA species. The assay was made ... T3). These enzymes possess several properties that,make them well suited for ...
Cached Biology Technology:PCR-Grade Nucleotides,Larger Pack Sizes Now Available 2Pwo Master*:,Simplify Setup of Your Proofreading PCRs 2Pwo Master*:,Simplify Setup of Your Proofreading PCRs 3RNase Protection Assay (RPA),Using DIG-Labeled RNA Probes 2
Collected from sexually mature, mixed sex, mixed breed guinea pigs. Pricing: $120/unit for 1 - 10 units...
Active GST Protein...
Marmoset plasma and serum - various quantities available...
Porcine Serum Available Anticoagulants: N-02: Citrate N-04: Heparin (Na) N-06: K2EDTA N-08: Potassium Oxalate N-10: EDTA (Na) N-03: Alsevers N-05: ACD N-07: CPD N-09: K3EDTA N-11...
Biology Products: