Navigation Links
Biologists probe the machinery of cellular protein factories

Proteins of all sizes and shapes do most of the work in living cells, and the DNA sequences in genes spell out the instructions for making those proteins. The crucial job of reading the genetic instructions and synthesizing the specified proteins is carried out by ribosomes, tiny protein factories humming away inside the cells of all living things.

Harry Noller, the Sinsheimer Professor of Molecular Biology at the University of California, Santa Cruz, has been studying the ribosome for more than 30 years. His main goal is to understand how the ribosome works and how it evolved, but there are also practical reasons to pursue this research. Many of the most effective antibiotics work by targeting bacterial ribosomes, and findings by Noller and others have led to the development of novel antibiotics that hold promise for use against germs that have developed resistance to current drugs. Drug-resistant staph infections, for example, are a serious problem in hospitals.

Noller's laboratory achieved breakthroughs in 1999 and 2001, producing the first high-resolution images of the molecular structure of a complete ribosome. Now, his team has made another major advance with an even higher-resolution image that enables them to construct an atom-by-atom model of the ribosome.

The new picture shows details never seen before and suggests how certain parts of the ribosome move during protein synthesis. A paper describing the new findings will be published in the September 22 issue of the journal Cell and is currently available online.

"We can now explain a lot of the results from biochemical and genetic studies carried out over the past several decades," Noller said. "This structure gives us another frame in the movie that will eventually show us the whole process of the ribosome in action."

The ribosome is a complex molecular machine made up of proteins and RNA molecules. The bacterial ribosomes studied in Noller's lab (obtained from
'"/>

Source:University of California - Santa Cruz


Page: 1 2 3

Related biology news :

1. Biologists discover why 10% of Europeans are safe from HIV
2. Biologists determine genetic blueprint of social amoeba
3. Biologists Crack Genetic Code for Specialized Spider Silk
4. Biologists discover new pathway into plant cells
5. Biologists visualize protein interaction that may initiate viral infection
6. Biologists develop genome-wide map of miRNA-mRNA interactions
7. How healthy is that marsh? Biologists count parasites
8. Biologists find regions of rice domestication
9. Biologists call for better choice of model organisms in evo-devo
10. Biologists produce global map of plant biodiversity
11. Biologists prove critical step in membrane fusion
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Biologists probe the machinery cellular protein factories

(Date:11/3/2014)... , Nov. 3, 2014 Research and ... "Cell Therapy - Technologies, Markets and Companies" to ... cell therapy technologies and methods, which have already started to ... stem cell transplantation is replacing the old fashioned bone marrow ... Cell therapy is bound to become a part of medical ...
(Date:11/3/2014)... report that low birth weight and preterm birth are ... in adulthood. Findings published in the American College of ... indicate that low birth weight and pre-term babies were ... OA as adults. , According to the ACR, ... diagnosed with clinical OA. Symptoms of OA range from ...
(Date:11/2/2014)... was fascinating to put a flashlight up to our ... Washington University in St. Louis engineers are using a ... to improve imaging of cancerous tissues and to develop ... K. Beare Distinguished Professor of Biomedical Engineering at the ... novel time-reversal technology that allows researchers to better focus ...
Breaking Biology News(10 mins):Global Cell Therapy - Technologies, Markets and Companies: 2014 Report 2Global Cell Therapy - Technologies, Markets and Companies: 2014 Report 3Preterm, low birth-weight babies may need new hips in adulthood 2Improving imaging of cancerous tissues by reversing time 2
... University of Toronto (U of T) have found that ... species opts for sexual over asexual reproduction. The ... Aneil Agrawal of the Department of Ecology & Evolutionary ... habitats characterized by uneven concentrations of its own ...
... Inc. (Nasdaq: AWRE ), a leading technology innovator ... a conference call to discuss the company,s operating results for ... 5:00 p.m. Eastern Time. President and CEO Edmund Reiter and ... This call is being webcast by Thomson and can ...
... A team of biomedical engineers from Columbia University, University ... million dollar, five-year Multi University Research Initiative (MURI) grant from ... blast waves on the neural circuitry of the brain. ... improvised explosive devices (IEDs), blast-induced traumatic brain injury (TBI) has ...
Cached Biology News:Aware, Inc. Announces Q3'10 Earnings Conference Call 2Columbia engineer part of team to receive $6.2 million DOD grant for blast research 2
(Date:11/21/2014)... Nov. 20, 2014 Polaris Group announced ... in its Phase 1 trial of ADI-PEG 20 ... treatment of malignant pleural mesothelioma (MPM) and non-squamous ... clinical trials on ADI-PEG 20, both as monotherapy ... treatment of several other indications, including breast cancer, ...
(Date:11/21/2014)... DIEGO , Nov. 20, 2014  Cytori Therapeutics (NASDAQ: ... Marc Hedrick , M.D. will present live at VirtualInvestorConferences.com on ... 2014 TIME:    11:15 am PT / 2:15 pm ... URL into your browser,s address bar: http://bit.ly/1B2KGaL ... and receive event updates. This will be ...
(Date:11/18/2014)... , Nov. 18, 2014 Cord Blood Registry® ... of the 10th Annual World Stem Cell Summit, the largest ... The 2014 World Stem Cell Summit will be held December ... Texas . The World Stem ... of lifesaving cures and therapies, convening the most prominent figures ...
(Date:11/18/2014)... November 17, 2014 Cirrascale ... architecture blade-based and rackmount computing infrastructure, today announced ... dual-GPU accelerator throughout its GPU-enabled blade server and ... the company’s latest proprietary 80-lane Gen3 PCIe switch-enabled ... NVIDIA Tesla K80 dual-GPU accelerator cards in a ...
Breaking Biology Technology:Polaris Group Announces Treatment of First Patient in Phase 1 Study of ADI-PEG 20 plus Pemetrexed and Cisplatin in Malignant Pleural Mesothelioma And Non-Squamous Non-Small Cell Lung Carcinoma 2Cytori Therapeutics to Provide Corporate Update and Investor Presentation on December 4 through a Live, Interactive Webcast 2Cytori Therapeutics to Provide Corporate Update and Investor Presentation on December 4 through a Live, Interactive Webcast 3Cytori Therapeutics to Provide Corporate Update and Investor Presentation on December 4 through a Live, Interactive Webcast 4Cord Blood Registry Sponsors 2014 World Stem Cell Summit 2Cord Blood Registry Sponsors 2014 World Stem Cell Summit 3Cirrascale® Expands Multi-GPU Peering Solutions with Support for New NVIDIA Tesla K80 Dual-GPU Accelerators 2Cirrascale® Expands Multi-GPU Peering Solutions with Support for New NVIDIA Tesla K80 Dual-GPU Accelerators 3
... Inc. (TSX: ONC, NASDAQ: ONCY ) ("Oncolytics") ... U.S. Patent, # 7,582,289, entitled "Viruses for the Treatment ... of using modified parapoxvirus orf virus to treat Ras-mediated ... portfolio regarding oncolytic viruses, in addition to reovirus, that ...
... WILMINGTON, Delaware, September 1 According ... (2009-2014),published by MarketsandMarkets ( http://www.marketsandmarkets.com ), the,global autoimmune ... 2014, with an estimated CAGR of 12.7% from 2009 ... for nearly 42% of the total revenues. , ...
... ... of continuous research, experiments and trials have given Centre for Jatropha Promotion ... alternative feedstock for biodiesel. After having a number of successful field trials ... source for Bio- Diesel industry of future and is happy to announce ...
Cached Biology Technology:Oncolytics Biotech(R) Inc. Announces Issuance of 32nd U.S. Patent 2MarketsandMarkets: Global Autoimmune Treatment Market Worth US$68.81 Billion by 2014 2MarketsandMarkets: Global Autoimmune Treatment Market Worth US$68.81 Billion by 2014 3MarketsandMarkets: Global Autoimmune Treatment Market Worth US$68.81 Billion by 2014 4Derris Indica is CJP's New Nonfood Biodiesel Crop for Profitable Sustainability 2Derris Indica is CJP's New Nonfood Biodiesel Crop for Profitable Sustainability 3
MAb to Yersinia pestis F1 Ag. Yersinia pestis F1 Antigen EB Strain...
Mouse monoclonal antibody to QDPR - quinoid dihydropteridine reductase...
... Signets FAST RED Chromogen System consists of ... RED reacts in the presence of alkaline ... background noise. The FAST RED System ... ,The System Contains: , , Vial A: ...
The BioLogic Maximizer mixer is for use with the Maximizer valve system. The mixer improves gradient quality by mixing the output of the BioLogic DuoFlow workstation pumps....
Biology Products: