Navigation Links
Biologists discover new pathway into plant cells

Researchers at Oregon State University have made a major discovery in basic plant biology that may set the stage for profound advances in plant genetics or biotechnology.

The scientists have identified for the first time a protein that can cross plant cell membranes, where it functions as a toxin to kill the cell. It had been known that viruses and bacteria can penetrate cell wall barriers and disrupt plant cells, but never before has a protein been found that could do this by itself.

When more research is done, this may provide a new tool to penetrate plant cells and possibly manipulate their behavior in some beneficial way ?to grow faster, resist disease or increase yields.

The findings were published today in two articles in The Plant Cell, a professional journal.

Also of considerable interest is that the biological mechanism discovered here bears striking similarity to the way proteins can function in mammalian cells ?scientists say they may have found a characteristic that has been preserved for more than 600 million years, when plants and animals diverged from a common ancestor on their separate evolutionary paths.

"This is a doorway into plant cells that we never knew existed," said Lynda Ciuffetti, an OSU professor of botany and plant pathology. "Viruses and bacteria have been known to bring proteins into cells, but this is just a protein by itself crossing the cell wall barrier without disrupting its integrity. This is a significant fundamental advance in our understanding of plant biology."

The research was done with a pathogenic fungus that causes tan spot of wheat, a costly plant disease that is found around the world, and in some places can cause crop losses ranging up to 50 percent. These fungi produce multiple toxins that attack wheat plants, reducing yields and ruining wheat used as seed. In the United States, it's a particular problem in the Great Plains and Midwest. Ciuffetti has spent much of her care er studying these "host-selective" toxins.

"Until now, we didn't really know exactly how the protein produced by this fungus was causing disease, whether it was from inside or outside of the plant cells," said Viola Manning, an OSU faculty research assistant and co-author of both publications. "No one had ever shown before that a protein could move, without a pathogen's assistance, from outside a plant cell to the inside. But in this case, the protein does penetrate the cell membrane and interacts with chloroplasts, ultimately leading to cell death."

The scientists said this mechanism probably will be found in other cells besides wheat, and with other proteins. And while it may lead ultimately to some way to help address this plant disease problem in wheat, the more important discovery is the new pathway into plant cells.

"We still don't know exactly how the protein penetrates the cell, but it's clear that it does," said Andrew Karplus, an OSU professor of biochemistry and biophysics. "And with work done by a graduate student, Ganapathy Sarma, we also now have a clear understanding of what the molecular structure of the toxin looks like. With continued research, we should not only be able to determine how the protein is getting into the cell, but also remove the toxic effect associated with it.

"What that would leave us with is a type of delivery vehicle, a completely new way to deliver compounds inside of a plant cell and target specific genes. This is a new and unprecedented insight into how plants can work."

The process of proteins getting inside of cells and affecting their behavior is common in animal cells, the scientists said. For instance, that's how the AIDS virus causes its damage. But the same process had never before been shown to exist in plant cells, which have been evolving separately from animals for hundreds of millions of years.

With a new delivery mechanism such as this, applied research could be don e either to help or harm plant cells ?by increasing or controlling their growth, or introducing new characteristics.


'"/>

Source:Oregon State University


Related biology news :

1. Biologists discover why 10% of Europeans are safe from HIV
2. Biologists determine genetic blueprint of social amoeba
3. Biologists Crack Genetic Code for Specialized Spider Silk
4. Biologists visualize protein interaction that may initiate viral infection
5. Biologists develop genome-wide map of miRNA-mRNA interactions
6. How healthy is that marsh? Biologists count parasites
7. Biologists find regions of rice domestication
8. Biologists probe the machinery of cellular protein factories
9. Biologists call for better choice of model organisms in evo-devo
10. Biologists produce global map of plant biodiversity
11. Biologists prove critical step in membrane fusion
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/28/2016)... SAN JOSE, Calif., Jan. 28, 2016 Synaptics (NASDAQ: ... financial results for its second quarter ended December 31, 2015. ... the second quarter of fiscal 2016 increased 2 percent compared to ... the second quarter of fiscal 2016 was $35.0 million, or $0.93 ... Non-GAAP net income for the first quarter of fiscal 2016 ...
(Date:1/25/2016)... , Jan. 25, 2016  Glencoe Software, the ... pharma and publication industries, will provide the data management ... Centre (NPSC). ... Phenotypic analysis measures ... whole organisms, allowing comparisons between states such as health ...
(Date:1/21/2016)... , January 21, 2016 ... to a new market research report "Emotion Detection and ... Others), Software Tools (Facial Expression, Voice Recognition and ... - Global forecast to 2020", published by MarketsandMarkets, ... expected to reach USD 22.65 Billion by 2020, ...
Breaking Biology News(10 mins):
(Date:2/5/2016)... 5, 2016 On Thursday, February 11, ... for community, health and disaster services, and the ... to enhance care coordination and service delivery for the ... need and to better connect service providers to the ... San Diego has handled more than ...
(Date:2/4/2016)... ... February 04, 2016 , ... Morf ... today announced an interactive FDA compliance training course, Writing Effective ... Professional Society) accredited interactive course on Morf Playbook—now conveniently available on smartphones and ...
(Date:2/4/2016)... ... 2016 , ... Shimadzu Scientific Instruments will showcase several new ... poster sessions, and present on the analysis of mycotoxins and medical cannabis at ... 10 at the Georgia World Congress Center in Atlanta, Georgia. , Attendees ...
(Date:2/4/2016)... JUNCTION, N.J. , Feb. 4, 2016 /PRNewswire/ ... care immunotherapy leader commercializing its flagship CytoSorb® blood ... cardiac surgery patients around the world, announced that ... will present at the Source Capital Group,s 2016 ... and update on the company.  ...
Breaking Biology Technology: