Navigation Links
Bioengineers create stable networks of blood vessels

Yale biomedical engineers have created an implantable system that can form and stabilize a functional network of fine blood vessels critical for supporting tissues in the body, according to a report in the Proceedings of the National Academy of Sciences.

For body tissue to survive it must receive oxygen delivered through the finest of blood vessels. Led by Erin Lavik, assistant professor of Biomedical Engineering, this study shows that the fine network of blood vessels can be formed. Further, detailed microscopic studies showed that the vascular networks were stable as implants for up to six weeks and were able to connect with larger blood vessel structures.

"This expands our understanding of the neuro-vascular niche and opens up ways to address repair of severed nerves," said Joseph Madri professor of pathology at Yale School of Medicine and a co-author. "We can now study what affects the attraction and repulsion of nerve growth and drug delivery in a model system that can be used in vitro and in vivo."

The researchers used two important engineering enhancements to develop stable functional microcirculation. First, they created a "micro-scaffold" of a macroporous hydrogel polymer. The hydrogel is a three-dimensional, sponge-like material -- highly water-saturable, with a structure of connected pores for cells to grow on and through.

Second, they seeded the hydrogel scaffolds with endothelial cells that make up blood vessel structure along with nerve progenitor cells from the brain. Because there is often an association of nerve connections with vascular networks, they tested to see if a combination of the blood vessel-forming and nerve-forming cells would enhance development of the vascular networks.

"By their nature, hydrogels are well suited for the transport of soluble factors, nutrients or drugs, and waste," said Lavik. "The hydrogel scaffold materials are generally highly biocompatible and safe to implant due to the pr esence of large volumes of water."


'"/>

Source:Yale University


Related biology news :

1. Chemists create Superbowl molecule; May lead to better health
2. Deficiency of growth hormone and IGF-1 reduces cancer and kidney disease, but creates other problems
3. RNA project to create language for scientists worldwide
4. Researcher gets NSF grant to create mutant maize lines
5. Breakthrough: Scientists create worlds tiniest organic particles
6. NIH creates nationwide network of molecular libraries screening centers
7. Researchers create infectious hepatitis C virus in a test tube
8. Ants, not evil spirits, create devils gardens in the Amazon rainforest, study finds
9. Researchers create functioning artificial proteins using natures rules
10. Scientists create digital bacteria to forge advances in biomedical research
11. Student scientists create living bacterial photographs
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/15/2016)... Research and Markets has announced ... 2016-2020,"  report to their offering.  , ... global gait biometrics market is expected to grow ... 2016-2020. Gait analysis generates multiple variables ... to compute factors that are not or cannot ...
(Date:4/13/2016)... 2016  IMPOWER physicians supporting Medicaid patients in ... clinical standard in telehealth thanks to a new partnership ... platform, IMPOWER patients can routinely track key health measurements, ... index, and, when they opt in, share them with ... a local retail location at no cost. By leveraging ...
(Date:3/31/2016)... , March 31, 2016  Genomics firm Nabsys has ... CEO, Barrett Bready , M.D., who returned to ... the original technical leadership team, including Chief Technology Officer, ... Product Development, Steve Nurnberg and Vice President of Software ... the company. Dr. Bready served as CEO ...
Breaking Biology News(10 mins):
(Date:5/3/2016)... 2016 The report "Biochips ... Gene Expression) Lab-on-a-chip (IVD & POC, Proteomics), ... Centers), Fabrication Technology (Microarrays, Microfluidics) - Forecast ... is expected to reach USD 17.75 Billion ... 2015, growing at a CAGR of 18.4% ...
(Date:5/3/2016)... ... May 03, 2016 , ... Leading ... 2016 on May 31st and June 1st at The Four Seasons Hotel Boston. ... in the life sciences, offering exclusive access to key decision makers who influence ...
(Date:5/3/2016)... ... May 03, 2016 , ... ... , the sensor and data driven conferences, will take place on June 7-8, 2016, at the ... UnitedHealth's Vidya Raman-Tangella on incorporating technology -- including AR/VR, machine learning, apps, robotics and ...
(Date:5/3/2016)... ... ... According to world renowned prostate cancer surgeon, Dr. David B. Samadi ... main treatment options: surgery or radiation. Based on a patient’s goals, disease state, and ... doctors to administer higher doses of radiation to prostate cancer patients with ...
Breaking Biology Technology: