Navigation Links
Bioelectronic ‘signatures?hold key to DNA mutations

me. Wang’s method allows for an accurate, ultra-sensitive, rapid and low-cost identification of these SNP variants.

“The novelty of the approach is the combination of the nanocrystal tagging of DNA to create electro-diverse signatures and combining them with a fast, portable, low-cost electronic detection,?Wang says.

To achieve the desired results, Wang and his researchers custom-made several individual nanocrystals, known as quantum dots, from four heavy metal salts of lead, cadmium, zinc and copper. Such nanocrystals were selected owing to their ability to yield distinct electronic signatures, with four well-resolved current peaks. Next, the nanocrystals are piggybacked onto individual DNA bases; these DNA bases ?each carrying a single nanocrystal ?bind to a DNA sample and cause minute electrical current changes in the nanocrystal that can be measured with an electrode. The individual base-conjugated nanocrystals are added sequentially to any DNA sample of interest, generating an electronic “fingerprint?that rapidly identifies all possible combinations of SNPs.

Wang’s results recently were featured as the cover story in the March issue of Analytical Chemistry and were published earlier this winter in the Journal of the American Chemical Society. The article can be found on the Web at (http://pubs3.acs.org/acs/journals/doilookup?in_doi=10.1021/ja043780a).


'"/>

Source:Arizona State University


Page: 1 2

Related biology news :

1. Novel technology detects human DNA mutations
2. Multi-species genome comparison sheds new light on evolutionary processes, cancer mutations
3. New view of cancer: Epigenetic changes come before mutations
4. ASU researchers wire DNA to identify mutations
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Bioelectronic hold key DNA mutations

(Date:4/23/2014)... release is available in French and German . ... or female? In humans and other mammals, the difference between sexes ... It is present only in males, where the two sexual chromosomes ... the Y is ultimately responsible for all the morphological and physiological ... been the case. A very long time ago, the X and ...
(Date:4/23/2014)... Huntington,s disease, most in their mid-thirties and forties, ... behavioral decline within two decades. "Mutant" protein clusters, ... disease, have been the primary focus of therapies ... new research from Prof. Gerardo Lederkremer and Dr. ... Cell Research and Immunology, in collaboration with Prof. ...
(Date:4/23/2014)... A team of researchers in Korea who ... brains of nonhuman primates and assessed cell survival ... that the hNSCs had differentiated into neurons at ... The study will be published in a future ... currently freely available on-line as an unedited early ...
Breaking Biology News(10 mins):Male or female? 2Male or female? 3On the defensive 2On the defensive 3Study finds long-term survival of human neural stem cells transplanted into primate brain 2
... Biology in the College of Arts and Science at ... 2011 Fitch Award for Excellence in Herpetology from the ... individuals who have demonstrated long-term excellence in the study ... of amphibian ecology and wetland conservation, Semlitsch is well-known ...
... When an animal gets too hot or too cold, or feels ... where it,s cooler or hotter, or to the nearest place where ... life? What can a plant do under similar circumstances? ... move to a more favorable spot. Yet they do respond ...
... TREW Marketing , a full-service firm focused on the ... for Engineers , a free guidebook for ... Available for download on TREW Marketing,s website , the ... and outlines the firm,s proven process to grow awareness ...
Cached Biology News:Ray Semlitsch receives 2011 Fitch Award for Excellence in Herpetology 2Plant biologists dissect genetic mechanism enabling plants to overcome environmental challenge 2Plant biologists dissect genetic mechanism enabling plants to overcome environmental challenge 3TREW Marketing Introduces Smart Marketing for Engineers, a Free Guidebook for Small Businesses Targeting Technical Audiences 2
(Date:1/14/2014)... provider of strategic communications services to corporations and organizations preparing for ... United States and Europe , today ... to the firm,s Washington, D.C. office. ... years of service as Associate Commissioner for the Office of External ...
(Date:1/14/2014)... Md. , Jan. 14, 2014  Organovo announced today ... the National Institutes of Health (NIH) to help scientists ... treatments to patients on a faster timeline. Organovo is ... (NCATS) and the National Eye Institute (NEI) to develop ...
(Date:1/14/2014)... Global Record Systems, LLC, (GRS), ... solutions for patients, physicians, the biopharmaceutical industry, regulators, ... the signing of a three-year Research Collaboration Agreement ... (FDA). This initiative is designed to generate ...
(Date:1/14/2014)... 2014 During the 1600’s through the 1800’s ... Doctor’s Plague.” In this time period, doctors did not know ... times, to the death of vulnerable patients. In the same ... they may be unwittingly transmitting herpes viruses to their patients. ...
Breaking Biology Technology:Former FDA Associate Commissioner Returns To 3D Communications 2Organovo Announces Collaboration with National Institutes of Health 2Organovo Announces Collaboration with National Institutes of Health 3Global Record Systems Announces Research Collaboration Agreement with FDA to Create a Novel “Big Data” Paradigm for Collection of Patient Safety and Outcomes Information 2Study: Fatigued Medical Interns Infect Their Patients with Herpes Viruses; The CBCD Sees a Parallel with “The Doctor’s Plague” 2Study: Fatigued Medical Interns Infect Their Patients with Herpes Viruses; The CBCD Sees a Parallel with “The Doctor’s Plague” 3
... MITI ) ("Micromet" or the "Company"), a ... of cancer,inflammation and autoimmune diseases, today announced that ... appointed Dr. Peter Johann, a,current member of the ... Company,s,audit committee. The appointment fills the vacancy left ...
... ALTO, Calif., Sept. 15 Varian, Inc.,(NasdaqGS: VARI) ... promoted,Sean M. Wirtjes, Vice President and Controller, to ... September 15, 2008. Wirtjes,assumes the Treasurer position from ... Vice President and Chief Financial Officer., The ...
... Inc.,(Amex: PIP ) a biodefense company ... countermeasures against chemical and,biological threats, announced today ... of Health and Human Services (DHHS) that ... anthrax vaccine,SparVax(TM), has completed a comprehensive technical ...
Cached Biology Technology:Micromet, Inc. Fills Audit Committee Vacancy and Regains Compliance With NASDAQ Marketplace Rule 2Micromet, Inc. Fills Audit Committee Vacancy and Regains Compliance With NASDAQ Marketplace Rule 3Micromet, Inc. Fills Audit Committee Vacancy and Regains Compliance With NASDAQ Marketplace Rule 4Varian, Inc. Board of Directors Makes Officer Changes 2PharmAthene Response to DHHS Request for Proposals for Recombinant Protective Antigen Anthrax Vaccine Deemed Technically Acceptable and Within Competitive Range for Procurement Consideration 2PharmAthene Response to DHHS Request for Proposals for Recombinant Protective Antigen Anthrax Vaccine Deemed Technically Acceptable and Within Competitive Range for Procurement Consideration 3PharmAthene Response to DHHS Request for Proposals for Recombinant Protective Antigen Anthrax Vaccine Deemed Technically Acceptable and Within Competitive Range for Procurement Consideration 4
The Magnetic Separation Rack is designed to be used for small-scale separations using magnetic particles. ,Capacity: 6 microcentrifuge tubes....
... contains 4 deuterium atoms at the 9, 10, ... use as an internal standard for the quantification ... is produced by the lipoxygenation of linoleic acid ... detected in atherosclerotic plaques, as an esterified component ...
5(S)-HETE-d8 is used as an internal standard for the quantification of 5(S)-HETE by stable isotope dilution mass spectrometry....
...
Biology Products: