Navigation Links
Bioelectronic ‘signatures?hold key to DNA mutations

me. Wang’s method allows for an accurate, ultra-sensitive, rapid and low-cost identification of these SNP variants.

“The novelty of the approach is the combination of the nanocrystal tagging of DNA to create electro-diverse signatures and combining them with a fast, portable, low-cost electronic detection,?Wang says.

To achieve the desired results, Wang and his researchers custom-made several individual nanocrystals, known as quantum dots, from four heavy metal salts of lead, cadmium, zinc and copper. Such nanocrystals were selected owing to their ability to yield distinct electronic signatures, with four well-resolved current peaks. Next, the nanocrystals are piggybacked onto individual DNA bases; these DNA bases ?each carrying a single nanocrystal ?bind to a DNA sample and cause minute electrical current changes in the nanocrystal that can be measured with an electrode. The individual base-conjugated nanocrystals are added sequentially to any DNA sample of interest, generating an electronic “fingerprint?that rapidly identifies all possible combinations of SNPs.

Wang’s results recently were featured as the cover story in the March issue of Analytical Chemistry and were published earlier this winter in the Journal of the American Chemical Society. The article can be found on the Web at (http://pubs3.acs.org/acs/journals/doilookup?in_doi=10.1021/ja043780a).


'"/>

Source:Arizona State University


Page: 1 2

Related biology news :

1. Novel technology detects human DNA mutations
2. Multi-species genome comparison sheds new light on evolutionary processes, cancer mutations
3. New view of cancer: Epigenetic changes come before mutations
4. ASU researchers wire DNA to identify mutations
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Bioelectronic hold key DNA mutations

(Date:7/9/2015)... , July 07, 2015 ... the addition of the "Biometrics for Banking; ... 2015-2020" report to their offering. ... contributor to this growth and the forecast is ... in revenue for companies involved in delivering biometric ...
(Date:7/9/2015)... , July 9, 2015  Synaptics ... developer of human interface solutions, today announced ... industry,s first fully hardware encapsulated fingerprint sensor ... authentication technology is literally off the grid, ... biometric matching within the fingerprint sensor to ...
(Date:7/8/2015)... YORK , July 8, 2015  BD (Becton, ... BD & Guidepoint Mentor, a new program ... Guidepoint,s expert network services. BD is ... to improve healthcare delivery and outcomes and, with the ... entrepreneur will be able to directly engage with industry ...
Breaking Biology News(10 mins):Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 2Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 3Synaptics Announces World's First Match-in-Sensor Fingerprint Authentication Technology 2Synaptics Announces World's First Match-in-Sensor Fingerprint Authentication Technology 3BD and Guidepoint Team to Connect Healthcare Start-up Companies With Business and Scientific Experts 2BD and Guidepoint Team to Connect Healthcare Start-up Companies With Business and Scientific Experts 3
... In a study of adults aged 20 and ... acid are at much higher levels in individuals who have ... levels than in individuals who are also vitamin B12 deficient ... methylmalonic acid, compounds used by enzymes that contain vitamin B12, ...
... pass genes to the next generation. In sexually reproducing ... are vital for fertility. In a new study published ... at Cornell University knocked down the levels of 25 ... males abilities to modulate egg production, sperm storage and ...
... to remain through reporting of 2007 fiscal year, ... (Nasdaq:,AWRE), a leading supplier of broadband technology and ... the position of Chief,Financial Officer beginning in February ... 1996 until September 2003., Keith Farris, Aware,s ...
Cached Biology News:Vitamin B-12 function may be diminished by excessive folate 2Aware, Inc. Announces Richard Moberg to Return as CFO 2Aware, Inc. Announces Richard Moberg to Return as CFO 3
(Date:8/3/2015)... -- According to a new market report ... Asia to Witness Highest Growth by ... culture market was valued at US$ 586.1 Mn in 2014 ... 29.1% to account for US$ 2,717.6 Mn by 2020. ... 3D cell culture refers to a process ...
(Date:7/31/2015)... LAS VEGAS , July 31, 2015 /PRNewswire/ ... pharmacists seek resources that help them drive positive ... as a vital source of patient care in ... Pharmacy,s annual tradeshow and conference, AmerisourceBergen announced ... strengthen its Pharmacy Services Administration Organization and help ...
(Date:7/31/2015)... ... July 31, 2015 , ... R-Biopharm ... quantification of partially hydrolyzed gluten in foods, has been accepted by AOAC International ... “Partially Hydrolyzed Gluten in Fermented Cereal-Based Products by R5 Competitive ELISA,” based on ...
(Date:7/30/2015)... Mass. , July 30, 2015   ... solutions for the interpretation and analysis of genomic ... Matthew Fischer has joined the company as ... Photo - http://photos.prnewswire.com/prnh/20150730/250931 ... capabilities to integrate, interpret, analyze and explore complex ...
Breaking Biology Technology:Global 3D Cell Culture Market Will Reach US$ 2,717.6 Million by 2020: Persistence Market Research 2Global 3D Cell Culture Market Will Reach US$ 2,717.6 Million by 2020: Persistence Market Research 3Global 3D Cell Culture Market Will Reach US$ 2,717.6 Million by 2020: Persistence Market Research 4AmerisourceBergen Unveils Suite of Enhanced Capabilities for Independent Pharmacies at ThoughtSpot 2015 2AmerisourceBergen Unveils Suite of Enhanced Capabilities for Independent Pharmacies at ThoughtSpot 2015 3RIDASCREEN® Competitve Gliadin Receives AOAC Official First Action Status 2GenoSpace Introduces Matthew Fischer as Vice President of Sales and Marketing 2
... ... in a dynamic and unpredictable world at Wharton Leadership Conference. , ... Philadelphia, PA (Vocus) June 16, 2009 -- As the ... is well-positioned to deliver dynamic innovations to meet the evolving markets demand because “change is ...
... , PHILADELPHIA, June 16 The Pew Charitable Trusts ... Fellows in the Biomedical Sciences. The rigorously competitive program provides ... with leading researchers in the United States. Upon returning to ... equipment to continue their research in their home countries. ...
... SHANGHAI, June 16 /PRNewswire-Asia/ -- WuXi PharmaTech ... Edward Hu, the Company,s Chief Operating Officer and,acting Chief ... Conference in New York on Wednesday, June 17, 2009, ... (Logo: http://www.newscom.com/cgi-bin/prnh/20040705/CNM002LOGO ) , ...
Cached Biology Technology:Leading for Growth in the New Economic Reality Includes Vision and Innovation 2Leading for Growth in the New Economic Reality Includes Vision and Innovation 3Ten Top Latin American Scientists Named 2009 Pew Fellows in the Biomedical Sciences 2Ten Top Latin American Scientists Named 2009 Pew Fellows in the Biomedical Sciences 3