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Biodegradable microspheres deliver time release vaccines, stimulate different immune response

ys Wilson-Welder.

The implications of these findings are two-fold, says Wilson-Welder. First, they have shown that polyanhydride microspheres can be used to deliver time-released vaccines. This could lead to the development of single-dose vaccines for diseases that currently require booster innoculations to be most effective, such as tetanus, whooping cough and chicken pox.

"The slow release mechanism of the polymers means that vaccines that currently require multiple doses might need only need a single dose in the future," says Wilson-Welder.

Secondly, the finding that vaccine adjuvants can elicit a CMI provides hope for vaccines against intracellular diseases that we currently don't have effective vaccines for, like malaria, tuberculosis and even AIDS.

"If we understand how an adjuvant activates the dendritic cells, we can start tailoring our vaccines to induce a better cellular response. If we can tailor the immune response, it holds greater promise for vaccines that we do not currently have," says Wilson-Welder.


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Source:American Society for Microbiology


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