Navigation Links
Biodegradable microspheres deliver time release vaccines, stimulate different immune response

A new vaccine delivery system using microspheres of a biodegradable polymer may not only reduce the need for booster shots in some cases, but also appears to stimulate an immune response that traditional vaccines do not. Researchers from Iowa State University report their findings today at the ASM Biodefense and Emerging Disease Research Meeting.

"Current vaccines are good at producing antibodies that block entry into the cell. In the case of some diseases, such as malaria or tuberculosis, antibody vaccines just aren't effective," says Jenny Wilson-Welder, a lead researcher on the study.

Wilson-Welder and her colleagues initially began their research looking for a way to eliminate the need for booster vaccinations, by developing a vaccine delivery system that released the vaccine into the system slowly over time. They chose a biodegradable polymer, called polyandydride, in a microsphere formulation. This polymer was already being used as a delivery system for a brain cancer drug designed to inhibit tumor growth.

"It's like an Everlasting Gobstopper or a bar of soap. It wears away slowly over time, delivering its payload," says Wilson-Welder.

The researchers vaccinated mice with microspheres loaded with ovalbumin, a protein from chicken eggs, and measured immune reponse. While mice exhibited the expected antibody response, the researchers also noticed something unexpected. The vaccine enhanced another type of immune response known as cellular-mediated immunity (CMI). CMI allows the immune system to identify, target and kill cells that have already become infected, something antibodies can not do.

The determine the cause of this effect, Wilson-Welder and her colleagues next incubated human dendritic cells in the presence of polyanhydride microspheres (without ovalbumin). Dendritic cells are responsible for initiating CMIs.

"We observed that the polymer microspheres were activating dendritic cells," sa
'"/>

Source:American Society for Microbiology


Page: 1 2

Related biology news :

1. Biodegradable napkin -- featuring sensitive nanofibers -- may quickly detect biohazards
2. New methods of gene delivery using lasers
3. Recombinant DNA technology may enable oral, rather than injectable, delivery of protein drugs
4. Self-assembled DNA buckyballs for drug delivery
5. New research could help us deliver genes for new bone formation
6. Cookbook recipes would cure disease with nontoxic DNA delivery systems
7. Discarded placentas deliver researchers promising cells similar to embryonic stem cells
8. Bare metal stents deliver gene therapy to heart vessels with less inflammation in animal studies
9. Targeted drug delivery achieved with nanoparticle-aptamer bioconjugates
10. Cellular scale drug delivery from the inside out
11. Wrinkled membranes create novel drug-delivery system
Post Your Comments:
(Date:5/22/2013)... feared Legionella pneumophila bacteria is responsible for ... In order to infect us, this pathogen has developed ... go unnoticed in our cells, thus avoiding these acting ... Basque biosciences research centre, CIC bioGUNE, in which teams ... USA and the National Supercomputation Centre in Barcelona (BSC) ...
(Date:5/22/2013)... Calif., May 22, 2013 Early screening for prostate ... pregnancy testing is for women, thanks to UC Irvine ... American Chemical Society . , After more than a ... way to clearly identify clinically usable markers for prostate ... detected far sooner, with greater accuracy and at dramatically ...
(Date:5/22/2013)... additives known as phthalates (pronounced THAL-ates) are odorless, ... in flooring, plastic cups, beach balls, plastic wrap, ... Control and Preventionthe bodies of most Americans. Once ... scrutiny. A growing collection of evidence suggests dietary ... and mix with food) may cause significant metabolic ...
Breaking Biology News(10 mins):Mechanism discovered which aids Legionella to camouflage itself in the organism 2UCI chemists devise inexpensive, accurate way to detect prostate cancer 2UCI chemists devise inexpensive, accurate way to detect prostate cancer 3Study links chemicals widely found in plastics and processed food to elevated blood pressure in children and teens 2
... in the Pacific Ocean as the likely culprit for ... to rivers and streams along the West Coast of ... Northwest and Southwest Fisheries Science Centers are comparing data ... in 2005 that occurred when this years returning salmon ...
... damage to plants from a sudden freeze that occurred across ... 2007 was made worse because it had been preceded by ... in the March 2008 issue of BioScience. The authors of ... Ridge National Laboratory and collaborators at NASA, the University of ...
... , The following schedule of press conferences is ... Meeting. Press conferences may be added or dropped, their ... All updates to this schedule will be announced in ... Center). Press conferences take place in the Press Room. ...
Cached Biology News:Unfavorable ocean conditions likely cause of low 2007 salmon returns along West Coast 2Will global warming increase plant frost damage? 22008 Ocean Sciences Meeting -- media advisory 2 22008 Ocean Sciences Meeting -- media advisory 2 32008 Ocean Sciences Meeting -- media advisory 2 42008 Ocean Sciences Meeting -- media advisory 2 52008 Ocean Sciences Meeting -- media advisory 2 62008 Ocean Sciences Meeting -- media advisory 2 72008 Ocean Sciences Meeting -- media advisory 2 82008 Ocean Sciences Meeting -- media advisory 2 9
(Date:5/23/2013)... Ralph Huber, President of PHI Management Solutions ... and emergency survival kits would be on sale through ... the quarterly executive board meeting on May 22nd. , ... the Oklahoma tornado victims and used the opportunity to remind ... kits is paramount. “When disaster strikes,” he said, “Our ...
(Date:5/22/2013)... Oven Industries announces the new 5R1-1400 ... via a PC through the TTL level UART Communication ... inches square can deliver up to 15 AMPS of ... solid state relay. Operator safety is achieved with 1KV ... and sensor input. Specifications: Input Voltage 85 to ...
(Date:5/22/2013)... iLuv Creative Technology, the premier provider of ... lifestyle, announces they are now shipping MultiCharger-X, an easy ... devices efficiently. Winner of the 2013 internationally recognized iF ... MultiCharger-X is revolutionizing the way businesses, schools, and medical ... , MultiCharger-X (iAD910) combines the best of ...
(Date:5/22/2013)... York (PRWEB) May 22, 2013 ... 3rd Annual Disruptive Innovations to Advance Clinical Trials conference ... Plaza Hotel in Boston, MA. , Disruptive thinkers ... Pharmaceuticals and more share bold approaches to reduce expensive ... , “Disruptive innovation needs to be big, or novel, ...
Breaking Biology Technology:PHI Emergency Management on Announces Father's Day Specials All Emergency Survival Kits 2New AC Temperature Controller Announced by Oven Industries 2iLuv Now Shipping the All New MultiCharger-X 2iLuv Now Shipping the All New MultiCharger-X 3Disruptive Innovation Hits Clinical Trials, Dedicated Event Launches 2
... N.J., April 23 Pharmacopeia,(Nasdaq: PCOP ), an ... therapeutics, today announced that the company plans to,release its ... 2008,after the close of market on Wednesday, May 7, ... at 5:00 p.m. EDT on the same day., ...
... ANGELES, April 23 Cord Blood America,Inc. (Pink ... preservation,company ( http://www.cordblood-america.com ) focused on bringing ... nationwide and internationally,today announced that it has been ... Angeles area by The Los Angeles Business Journal., ...
... Md., April 22 EntreMed, Inc.,(Nasdaq: ENMD ... treatment of cancer and inflammatory diseases, today,announced that ... seeking,stockholder approval for a reverse stock split at ... June 5, 2008. In light of recent gains ...
Cached Biology Technology:Pharmacopeia to Host First Quarter 2008 Financial Results Webcast and Conference Call 2Pharmacopeia to Host First Quarter 2008 Financial Results Webcast and Conference Call 3Cord Blood America in Top 20 in Los Angeles Area Biotech-Biomed Companies 2EntreMed Will Not Seek Shareholder Approval for Reverse Stock Split at Annual Meeting 2EntreMed Will Not Seek Shareholder Approval for Reverse Stock Split at Annual Meeting 3
Mouse monoclonal antibody raised against a partial recombinant NEK2. NCBI Entrez Gene ID = NEK2...
... Minis 300V power supply (Cat. No. Minis ... sufficient for SDS-PAGE, and native PAGE applications. ... of terminator pairs can be used simultaneously. ... individuals to have his/her own power supply ...
... premium quality recombinant form of Thermus aquaticus ... for a wide range of PCR applications. ... performance, each preparation is extensively tested in ... DNA Polymerase possesses an integral 5′→3′ exonuclease ...
Mouse monoclonal antibody raised against a partial recombinant COG2. NCBI Entrez Gene ID = COG2...
Biology Products: