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Biodegradable microspheres deliver time release vaccines, stimulate different immune response

A new vaccine delivery system using microspheres of a biodegradable polymer may not only reduce the need for booster shots in some cases, but also appears to stimulate an immune response that traditional vaccines do not. Researchers from Iowa State University report their findings today at the ASM Biodefense and Emerging Disease Research Meeting.

"Current vaccines are good at producing antibodies that block entry into the cell. In the case of some diseases, such as malaria or tuberculosis, antibody vaccines just aren't effective," says Jenny Wilson-Welder, a lead researcher on the study.

Wilson-Welder and her colleagues initially began their research looking for a way to eliminate the need for booster vaccinations, by developing a vaccine delivery system that released the vaccine into the system slowly over time. They chose a biodegradable polymer, called polyandydride, in a microsphere formulation. This polymer was already being used as a delivery system for a brain cancer drug designed to inhibit tumor growth.

"It's like an Everlasting Gobstopper or a bar of soap. It wears away slowly over time, delivering its payload," says Wilson-Welder.

The researchers vaccinated mice with microspheres loaded with ovalbumin, a protein from chicken eggs, and measured immune reponse. While mice exhibited the expected antibody response, the researchers also noticed something unexpected. The vaccine enhanced another type of immune response known as cellular-mediated immunity (CMI). CMI allows the immune system to identify, target and kill cells that have already become infected, something antibodies can not do.

The determine the cause of this effect, Wilson-Welder and her colleagues next incubated human dendritic cells in the presence of polyanhydride microspheres (without ovalbumin). Dendritic cells are responsible for initiating CMIs.

"We observed that the polymer microspheres were activating dendritic cells," sa
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Source:American Society for Microbiology


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