Navigation Links
Biochemists report discovery of structure of major piece of telomerase; implications for cancer

UCLA biochemists have determined the three-dimensional structure of a major domain of telomerase, the enzyme that helps maintain telomeres ?small pieces of DNA on the ends of chromosomes that act as protective caps -- allowing DNA ends to be copied completely when cells are replicated.

This is the first major piece of telomerase for which the structure is known. Telomerase plays a key role in most cancers, and this work ultimately may lead to targets for drug intervention, the scientists said. The discovery is the cover story in the March 4 issue of the journal Molecular Cell.

"Knowledge of the structure should provide insights into how telomerase works," said Juli Feigon, professor of chemistry and biochemistry at UCLA, who led the research group. "Knowing the structure also will allow the pursuit of rational, structure-based drug design, and is a critical first step. The structure provides a potential target for drug intervention."

Feigon emphasized that her laboratory conducts basic research, and is not involved in cancer treatment.

Every time a cell divides, telomeres, which act like the plastic tips on the ends of shoelaces, get shorter. In the natural aging process, the telomeres eventually get so short that cells can no longer divide, and they die. While telomerase is turned off in most types of healthy cells in our bodies, it is active in the vast majority of cancer cells, Feigon said.

Because cancer cells divide rapidly, their telomeres should get shorter more quickly than normal cells. However, because cancer cells have high levels of telomerase activity, which rebuilds the telomeres, cancer cells can maintain the length of their telomeres indefinitely. Although it is not known whether telomerase activation is just a marker for cancer cells or involved in causing it, telomerase is an attractive target for development of anti-cancer drugs by pharmaceutical companies.

The research, which was federally funded by
'"/>

Source:University of California - Los Angeles


Page: 1 2 3

Related biology news :

1. Octopuses occasionally stroll around on two arms, UC Berkeley biologists report
2. Surprising findings reported about iron overload
3. Researchers report new pro-inflammatory role for anti-inflammatory enzyme
4. Leprosy genome tells story of human migrations, French researchers report in Science
5. Novel live reporting system to track cells
6. Biased reporting found in cancer prognostic studies
7. New lead reported in tumor angiogenesis
8. Researchers report breakthrough against world’s deadliest viruses
9. UW scientists report a new method to speed bird flu vaccine production
10. Many cats unaffected by catnip, C&EN reports
11. Careless reporting on HIV could cost lives
Post Your Comments:
(Date:9/17/2014)... has received a $260,000 grant from the Andrew W. ... the Human in the Age of the Life Sciences." ... events aimed at exploring two compelling themes in the ... are exploring the boundaries of our self-definition as a ... involves the increasingly influential hypothesis that we are living ...
(Date:9/17/2014)... EC-FP5 four-year project, delivering its first release in 2004. ... in several EC projects, as a part of the ... BON), to increase the general awareness of the work ... dissemination of the Fauna Europaea results, the ... e-Publishing tools to prepare data papers for all 56 ...
(Date:9/17/2014)... cleverly, some lessons on how to create the features ... director of the Optical Technology Center at Montana State ... nanoscale, we,ll discover them." , Some of those lessons ... conference called "The Nature of Light: Light in Nature" ... of Arizona College of Optical Sciences. The conference was ...
Breaking Biology News(10 mins):Mellon Foundation awards grant for major project in the humanities and sciences 2Contributions on Fauna Europaea: Data papers as innovative model on expert involvement 2Nature's designs inspire research into new light-based technologies 2Nature's designs inspire research into new light-based technologies 3
... of birds reproduce not by rearing their own young, but ... Known as brood parasitism, this habit has been most thoroughly ... the nests of martins and swallows in Europe are rarely ... the Hainan Normal University in China and his colleagues suggests ...
... research team has identified seven new gene loci linked to obesity. ... cause extreme obesity are similar to those that cause milder forms ... people were included in the study of the links between genes ... Nature Genetics . The aim of the study was to ...
... 2013, Cleveland: A compound abundant in red meat and added ... to promote atherosclerosis or the hardening or clogging of ... this week in the journal Nature Medicine . ... digestive tract metabolize the compound carnitine, turning it into trimethylamine-N-oxide ...
Cached Biology News:Birds find ways to avoid raising cuckoos' young 2Genes behind obesity mapped in large-scale study 2Cleveland Clinic researchers discover new link between heart disease and red meat 2Cleveland Clinic researchers discover new link between heart disease and red meat 3
(Date:9/18/2014)... TX (PRWEB) September 18, 2014 ... integrated urological and interventional radiology products and services, ... known as cryotherapy and cryoablation) versus external beam ... Section of the American Urological Association (MAAUA) Annual ... , "Comparing Relative Effectiveness of Cryosurgery and External ...
(Date:9/18/2014)... , September 18, 2014 ... ( http://www.researchandmarkets.com/research/czvg3s/biocompatible ) has announced the ... - Global Strategic Business Report" ... http://photos.prnewswire.com/prnh/20130307/600769) ,This report analyzes the worldwide ... Million by the following Product Segments: ...
(Date:9/18/2014)... 2014 Research and Markets has ... Industry Report 2014" report to their offering. ... is a professional and in-depth study on the current ... The report provides a basic overview of the industry ... human albumin market analysis is provided for the international ...
(Date:9/18/2014)... Ky. , Sept. 18, 2014  Neogen Corporation ... has entered into a strategic agreement with Merck Animal ... Program. The Igenity Dairy Heifer Program ... essential information on the genetic potential of replacement dairy ... a calf is born, and is an excellent tool ...
Breaking Biology Technology:HealthTronics Announces Data Comparing Cryotherapy Versus Radiation for Treating Prostate Cancer Poster Presented at the American Urological Association Regional Meeting 2Biocompatible Materials - Global Strategic Business Report 2014 2Biocompatible Materials - Global Strategic Business Report 2014 3Global Human Albumin Industry Report 2014 2Global Human Albumin Industry Report 2014 3Merck Animal Health to market Neogen's dairy genomic program 2
... few months, 2004 delivered some promising advances in Wisconsin technology. ... has set in motion public initiatives to help entrepreneurs and ... Technology Network just turned two. To celebrate, here are some ... leading CIOs ,Wisconsins CIOs continue to push IT forward ...
... realm of content management systems (CMS) providers, Northwoods ... for clients. Forget the gearhead techno-speak. The Milwaukee area ... issues through plain talk and better Web design. , ... Web, said Pat Bieser, founder and CEO of the ...
... agencies have backed a new organization, the Wisconsin Angel ... , ,Wisconsin excels in researching and developing cutting-edge technology ... first and most critical stage, said Governor ... , ,The Wisconsin Technology Council , which advises ...
Cached Biology Technology:2004 in review: Editors picks 22004 in review: Editors picks 3Untangling the Web: Northwoods Software in profile 2Untangling the Web: Northwoods Software in profile 3Untangling the Web: Northwoods Software in profile 4Untangling the Web: Northwoods Software in profile 5
... vaccinia virus is a type I eukaryotic ... superhelical turns (also called right- and left-handed ... of the reaction is a covalently closed, ... superhelical turns. DNA Topoisomerase I does not ...
Applications include ELISA, immunochemistry, and Western blotting. Working Concentrations: ELISA: 0.005-0.05 U/ml, immunohisto/cytochemistry: 0.25-0.5 U/ml, Western blot: 0.1-0.25 U/ml....
...
Recombinant Ovine IFN Tau. Active on sheep, cow, human and mouse cells. Activity: 5.7 x 10 7 u/mg...
Biology Products: