Navigation Links
Bioactive cement scaffold may improve bone grafts

A new technology for implants that may improve construction or repair of bones in the face, skull and jaw, has been developed by researchers from the American Dental Association Foundation (ADAF) and the National Institute of Standards and Technology (NIST).

Described in recent and upcoming journal articles,* the new technology provides a method for making scaffolds for bone tissue. The scaffold is seeded with a patient's own cells and is formed with a cement paste made of minerals also found in natural bone. The paste is mixed with beads of a natural polymer (made from seaweed) filled with bone cells. The paste is shaped or injected into a bone cavity and then allowed to harden with the encapsulated cells dispersed throughout the structure. The natural polymer beads gradually dissolve when exposed to the body's fluids, creating a scaffold that is filled by the now released bone cells.

The cement, a calcium phosphate material, is strengthened by adding chitosan, a biopolymer extracted from crustacean shells. The implant is further reinforced to about the same strength as spongy natural bone by covering it with several layers of a biodegradable fiber mesh already used in clinical practice.

"Bone cells are very smart," says Hockin Xu, of the ADAF and principal investigator for the project. "They can tell the difference between materials that are bioactive compared to bioinert polymers. Our material is designed to be similar to mineral in bone so that cells readily attach to the scaffold." The researchers used mouse bone cells in their experiments, but in practice surgeons would use cells cultured from patient samples. In addition to creating pores in the hardened cement, the natural polymer beads protect the cells during the 30 minutes required for the cement to harden. Future experiments will develop methods for improving the material's mechanical properties by using smaller encapsulating beads that biodegrade at a predictable rate.

NIST and the American Dental Association Foundation have conducted cooperative research on dental and medical materials since 1928. ADAF researchers focus on development of new dental materials, while NIST specializes in the development of improved technologies and methods for measuring materials properties.


'"/>

Source:National Institute of Standards and Technology (NIST)


Related biology news :

1. Advancements In Genomics Foster Deep Sea Discoveries
2. Computer models aid understanding of antibody-dependent enhancement in spread of dengue fever
3. Findings advance use of adult stem cells for replacement bone
4. Genes may determine success of hip replacement surgery
5. Percutaneous aortic valve replacement safe, successful in high-risk patients
6. Tiny scaffolding allows stem cells to become working fat cells
7. Microscopic scaffolding offers a simple solution to treating skin injuries
8. Bedsores and bald hides: Novel roles revealed for a scaffolding protein
9. MIT creates 3-D scaffold for growing stem cells
10. Woven scaffolds could improve cartilage repair
11. Tissue engineered scaffolding allows reproduction of cartilage tissue
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/11/2017)... 11, 2017 No two people are ... the New York University Tandon School of Engineering ... found that partial similarities between prints are common ... mobile phones and other electronic devices can be ... vulnerability lies in the fact that fingerprint-based authentication ...
(Date:4/5/2017)... LONDON , April 4, 2017 KEY ... is anticipated to expand at a CAGR of 25.76% ... neurodegenerative diseases is the primary factor for the growth ... full report: https://www.reportbuyer.com/product/4807905/ MARKET INSIGHTS The ... of product, technology, application, and geography. The stem cell ...
(Date:3/30/2017)... NEW YORK , March 30, 2017 ... by type (physiological and behavioral), by technology (fingerprint, AFIS, ... recognition, voice recognition, and others), by end use industry ... travel and immigration, financial and banking, and others), and ... Europe , Asia Pacific ...
Breaking Biology News(10 mins):
(Date:6/19/2017)... ... June 19, 2017 , ... Tunnell Consulting has been solving the ... the biggest challenges faced by life sciences, biotech and pharmaceuticals companies today is in ... Kati Abraham , who is well known in the industry and brings significant high-level ...
(Date:6/16/2017)... ... 16, 2017 , ... Cambridge Semantics , the leading ... Smart Data Lake® (Anzo SDL) solution was named a finalist in the ... Information Industry Association (SIIA) CODiE Awards. , Finalists represent the best products, ...
(Date:6/15/2017)... , ... June 15, 2017 , ... ... has secured a Series B round of financing in the amount of $6 ... of private investors participated in the round. , The Series B funding will ...
(Date:6/15/2017)... ... June 15, 2017 , ... ... DuPont Biofuels, will be speaking at Bloomberg’s 2017 Sustainable Business Summit: Seattle ... leading environmental and sustainability officials on a panel titled “Developing a Corporate Renewables ...
Breaking Biology Technology: