Navigation Links
Bioactive cement scaffold may improve bone grafts

A new technology for implants that may improve construction or repair of bones in the face, skull and jaw, has been developed by researchers from the American Dental Association Foundation (ADAF) and the National Institute of Standards and Technology (NIST).

Described in recent and upcoming journal articles,* the new technology provides a method for making scaffolds for bone tissue. The scaffold is seeded with a patient's own cells and is formed with a cement paste made of minerals also found in natural bone. The paste is mixed with beads of a natural polymer (made from seaweed) filled with bone cells. The paste is shaped or injected into a bone cavity and then allowed to harden with the encapsulated cells dispersed throughout the structure. The natural polymer beads gradually dissolve when exposed to the body's fluids, creating a scaffold that is filled by the now released bone cells.

The cement, a calcium phosphate material, is strengthened by adding chitosan, a biopolymer extracted from crustacean shells. The implant is further reinforced to about the same strength as spongy natural bone by covering it with several layers of a biodegradable fiber mesh already used in clinical practice.

"Bone cells are very smart," says Hockin Xu, of the ADAF and principal investigator for the project. "They can tell the difference between materials that are bioactive compared to bioinert polymers. Our material is designed to be similar to mineral in bone so that cells readily attach to the scaffold." The researchers used mouse bone cells in their experiments, but in practice surgeons would use cells cultured from patient samples. In addition to creating pores in the hardened cement, the natural polymer beads protect the cells during the 30 minutes required for the cement to harden. Future experiments will develop methods for improving the material's mechanical properties by using smaller encapsulating beads that biodegrade at a predictable rate.


'"/>

Source:National Institute of Standards and Technology (NIST)


Page: 1 2

Related biology news :

1. Advancements In Genomics Foster Deep Sea Discoveries
2. Computer models aid understanding of antibody-dependent enhancement in spread of dengue fever
3. Findings advance use of adult stem cells for replacement bone
4. Genes may determine success of hip replacement surgery
5. Percutaneous aortic valve replacement safe, successful in high-risk patients
6. Tiny scaffolding allows stem cells to become working fat cells
7. Microscopic scaffolding offers a simple solution to treating skin injuries
8. Bedsores and bald hides: Novel roles revealed for a scaffolding protein
9. MIT creates 3-D scaffold for growing stem cells
10. Woven scaffolds could improve cartilage repair
11. Tissue engineered scaffolding allows reproduction of cartilage tissue
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Bioactive cement scaffold may improve bone grafts

(Date:7/11/2014)... China Researchers from Salk Institute for Biological Studies, ... evaluated the safety and reliability of the existing ... new method, TALEN-HDAdV, which could significantly increased gene-correction ... This study published online in Cell Stell ... stem cell-based gene therapy. , The combination of ...
(Date:7/11/2014)... Researchers from Ume University, Sweden, have explored two ... the reaction sequence leading to the formation of ... been published in the scientific journal Nature ... improving present day synthetic catalysts for water oxidation, ... devices for the direct storage of solar energy ...
(Date:7/11/2014)... has demonstrated that transplantation of mesenchymal stem cells can ... mouse models of Alzheimer,s disease (AD) and improve tissue ... Few studies are reported on the therapeutic effect of ... and on the effect on oxidative injury and neurogenesis ... and her team, School of Life Sciences, Tsinghua University, ...
Breaking Biology News(10 mins):A new genome editing method brings the possibility of gene therapies closer to reality 2Molecular snapshots of oxygen formation in photosynthesis 2
... Botanists at Oregon State University have discovered that a ... at the same time it produces susceptibility to a ... has ever been observed in plants. The finding, ... of Sciences, may help scientists better understand the pathways ...
... coastal waters interfere with fish reproduction by disrupting the ... Texas at Austin Marine Science Institute has found. ... hypoxia, have increased dramatically in coastal waters throughout the ... result of increased run-off from human agricultural and industrial ...
... Saudi Arabia (August 30, 2007) Saudi Arabias King ... the Indian Institute of Technology, Bombay (IIT Bombay) ... 2, 2007, to work together to foster world-class programs that ... development in fundamental and applied chemical sciences for the benefit ...
Cached Biology News:Same gene protects from 1 disease, opens door to another 2Low oxygen in coastal waters impairs fish reproduction 2Saudi Arabia's KAUST and IIT, Bombay to Collaborate on Scientific Research 2
(Date:7/10/2014)... Ouagadougou, Burkina Faso (PRWEB) July 10, 2014 ... Burkina Faso, today have access to an additional ... to increase access to contraception at all levels ... combining a lower-dose formulation of a widely used ... injection system. , Burkina Faso is the first ...
(Date:7/10/2014)... UK (PRWEB) July 10, 2014 ... 21st Century Medicine Forum on ‘Commercialising Longevity Research’ ... and entrepreneurs to the London Bioscience Innovation Center ... Research Foundation and Aging Analytics Ltd. The meeting ... investment in translational research for age-related disease, as ...
(Date:7/10/2014)... Terascala, the industry leader in ... a former vice president of product management for Flexera ... of marketing. Terascala’s software when combined with leading compute ... highest performance and most reliable solutions for processing big ... channel expansion and broaden its product portfolio. His leadership ...
(Date:7/10/2014)... Robert Harman, DVM, Founder and CEO of Vet-Stem, Inc., ... the relaunch of his highly informative blog, now named Stem ... What are Stem Cells ?” Dr. Harman’s purpose for ... the basics of stem cell therapy so that pet owners ... treatment when considering regenerative medicine. , A veterinarian by trade, ...
Breaking Biology Technology:Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 2Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 3Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 4Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 5Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 6DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 2DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 3DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 4DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 5DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 6Terascala Expands Executive Team 2Terascala Expands Executive Team 3Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 2Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 3
... - AEterna Zentaris Inc. (NASDAQ: AEZS ... on endocrine therapy and oncology, announced today that ... offering of US$10 million of units comprised of ... certain institutional investors. AEterna Zentaris received net proceeds ...
... 24 Cancer therapies and diagnostics, including new technologies, enhanced ... testing, will be at the center of Cleveland Clinic,s 7th ... Summit will bring together more than 900 leaders from throughout ... cancer care, exchange perspectives and gain actionable insights. , ...
... & Industry Milestone of 1000 + Egg Donors , ... collaboration of egg donor agencies through out the United States, ... web-based collective of egg donors - has quickly become one ... more than one thousand diverse and multi-cultural egg donor candidates. ...
Cached Biology Technology:AEterna Zentaris Receives US$10 Million from Institutional Investors 2AEterna Zentaris Receives US$10 Million from Institutional Investors 32009 Medical Innovation Summit at Cleveland Clinic to Highlight the Latest Developments in Cancer Care 22009 Medical Innovation Summit at Cleveland Clinic to Highlight the Latest Developments in Cancer Care 3First-Ever Egg Donor Web Portal Becomes One of The Largest Resources for Aspiring Parents in the U.S. 2
... Five cells (BTI-TN-5B1-4) derived from Trichoplusia ... shown to be capable of expressing ... proteins compared to other insect cells. ... features:- -Rapid doubling time as adherent cultures- Quick ...
... offers the most comprehensive, cost-effective solution ... have incorporated unprecedented quality into both ... includes proven detection chemistries and antibodies ... TechMate protocol. It also includes our ...
...
...
Biology Products: