Navigation Links
Bioactive cement scaffold may improve bone grafts

A new technology for implants that may improve construction or repair of bones in the face, skull and jaw, has been developed by researchers from the American Dental Association Foundation (ADAF) and the National Institute of Standards and Technology (NIST).

Described in recent and upcoming journal articles,* the new technology provides a method for making scaffolds for bone tissue. The scaffold is seeded with a patient's own cells and is formed with a cement paste made of minerals also found in natural bone. The paste is mixed with beads of a natural polymer (made from seaweed) filled with bone cells. The paste is shaped or injected into a bone cavity and then allowed to harden with the encapsulated cells dispersed throughout the structure. The natural polymer beads gradually dissolve when exposed to the body's fluids, creating a scaffold that is filled by the now released bone cells.

The cement, a calcium phosphate material, is strengthened by adding chitosan, a biopolymer extracted from crustacean shells. The implant is further reinforced to about the same strength as spongy natural bone by covering it with several layers of a biodegradable fiber mesh already used in clinical practice.

"Bone cells are very smart," says Hockin Xu, of the ADAF and principal investigator for the project. "They can tell the difference between materials that are bioactive compared to bioinert polymers. Our material is designed to be similar to mineral in bone so that cells readily attach to the scaffold." The researchers used mouse bone cells in their experiments, but in practice surgeons would use cells cultured from patient samples. In addition to creating pores in the hardened cement, the natural polymer beads protect the cells during the 30 minutes required for the cement to harden. Future experiments will develop methods for improving the material's mechanical properties by using smaller encapsulating beads that biodegrade at a predictable rate.

NIST and the American Dental Association Foundation have conducted cooperative research on dental and medical materials since 1928. ADAF researchers focus on development of new dental materials, while NIST specializes in the development of improved technologies and methods for measuring materials properties.


'"/>

Source:National Institute of Standards and Technology (NIST)


Related biology news :

1. Advancements In Genomics Foster Deep Sea Discoveries
2. Computer models aid understanding of antibody-dependent enhancement in spread of dengue fever
3. Findings advance use of adult stem cells for replacement bone
4. Genes may determine success of hip replacement surgery
5. Percutaneous aortic valve replacement safe, successful in high-risk patients
6. Tiny scaffolding allows stem cells to become working fat cells
7. Microscopic scaffolding offers a simple solution to treating skin injuries
8. Bedsores and bald hides: Novel roles revealed for a scaffolding protein
9. MIT creates 3-D scaffold for growing stem cells
10. Woven scaffolds could improve cartilage repair
11. Tissue engineered scaffolding allows reproduction of cartilage tissue
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/9/2016)... leader in attendance control systems is proud to announce the introduction of fingerprint attendance ... the right employees are actually signing in, and to even control the opening of ... ... ... Photo - ...
(Date:6/2/2016)... , June 2, 2016 The ... has awarded the 44 million US Dollar project, for ... Embossed Vehicle Plates including Personalization, Enrolment, and IT Infrastructure ... leader in the production and implementation of Identity Management Solutions. ... January, however Decatur was selected for ...
(Date:5/24/2016)... facilitates superior patient care by providing unparalleled technology to leaders of the medical imaging ... product recently added to the range of products distributed by Ampronix. Photo ... ... ... News ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... -- A person commits a crime, and the detective uses ... criminal down. An outbreak of foodborne illness makes ... uses DNA evidence to track down the bacteria that caused ... not. The FDA has increasingly used a complex, cutting-edge technology ... Put as simply as possible, whole genome sequencing is a ...
(Date:6/23/2016)...  The Prostate Cancer Foundation (PCF) is pleased to announce 24 ... for prostate cancer. Members of the Class of 2016 were selected from a ... Read More About the Class of 2016 PCF Young Investigators ... ... ...
(Date:6/23/2016)... (PRWEB) , ... June 23, 2016 , ... ... today announced the launch of the Supplyframe Design Lab . Located in ... to explore the future of how hardware projects are designed, built and brought ...
(Date:6/23/2016)... 2016 Apellis Pharmaceuticals, Inc. today announced ... of its complement C3 inhibitor, APL-2. The trials ... dose studies designed to assess the safety, tolerability, ... in healthy adult volunteers. Forty subjects ... single dose (ranging from 45 to 1,440mg) or ...
Breaking Biology Technology: