Navigation Links
Bioactive cement scaffold may improve bone grafts

A new technology for implants that may improve construction or repair of bones in the face, skull and jaw, has been developed by researchers from the American Dental Association Foundation (ADAF) and the National Institute of Standards and Technology (NIST).

Described in recent and upcoming journal articles,* the new technology provides a method for making scaffolds for bone tissue. The scaffold is seeded with a patient's own cells and is formed with a cement paste made of minerals also found in natural bone. The paste is mixed with beads of a natural polymer (made from seaweed) filled with bone cells. The paste is shaped or injected into a bone cavity and then allowed to harden with the encapsulated cells dispersed throughout the structure. The natural polymer beads gradually dissolve when exposed to the body's fluids, creating a scaffold that is filled by the now released bone cells.

The cement, a calcium phosphate material, is strengthened by adding chitosan, a biopolymer extracted from crustacean shells. The implant is further reinforced to about the same strength as spongy natural bone by covering it with several layers of a biodegradable fiber mesh already used in clinical practice.

"Bone cells are very smart," says Hockin Xu, of the ADAF and principal investigator for the project. "They can tell the difference between materials that are bioactive compared to bioinert polymers. Our material is designed to be similar to mineral in bone so that cells readily attach to the scaffold." The researchers used mouse bone cells in their experiments, but in practice surgeons would use cells cultured from patient samples. In addition to creating pores in the hardened cement, the natural polymer beads protect the cells during the 30 minutes required for the cement to harden. Future experiments will develop methods for improving the material's mechanical properties by using smaller encapsulating beads that biodegrade at a predictable rate.

NIST and the American Dental Association Foundation have conducted cooperative research on dental and medical materials since 1928. ADAF researchers focus on development of new dental materials, while NIST specializes in the development of improved technologies and methods for measuring materials properties.


'"/>

Source:National Institute of Standards and Technology (NIST)


Related biology news :

1. Advancements In Genomics Foster Deep Sea Discoveries
2. Computer models aid understanding of antibody-dependent enhancement in spread of dengue fever
3. Findings advance use of adult stem cells for replacement bone
4. Genes may determine success of hip replacement surgery
5. Percutaneous aortic valve replacement safe, successful in high-risk patients
6. Tiny scaffolding allows stem cells to become working fat cells
7. Microscopic scaffolding offers a simple solution to treating skin injuries
8. Bedsores and bald hides: Novel roles revealed for a scaffolding protein
9. MIT creates 3-D scaffold for growing stem cells
10. Woven scaffolds could improve cartilage repair
11. Tissue engineered scaffolding allows reproduction of cartilage tissue
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/8/2017)... YORK , Feb. 7, 2017 ... Driven largely by the confluence of organizations, desires ... distaste for knowledge-based systems (password and challenge questions), ... industrial, and government systems. The market is driven ... a demarcation between consumer and enterprise uses cases, ...
(Date:2/6/2017)... 2017 According to Acuity Market Intelligence, ... authorities to continue to embrace biometric and digital ... Automated Border Control (ABC) eGates and 1436 Automated ... than 163 ports of entry across the globe. ... a combined CAGR of 37%. APC Kiosks reached ...
(Date:2/2/2017)... -- Central to its deep commitment to honor the ... Prize Foundation today announced the laureates of the ... in their respective fields of Life Sciences and ... recognized with the 2017 Japan Prize for original ... the advancement of science and technology, but also ...
Breaking Biology News(10 mins):
(Date:2/18/2017)... -- Research and Markets has announced the addition of ... their offering. ... The report provides separate comprehensive analytics for the US, ... World. Annual estimates and forecasts are provided for the period 2015 ... markets. Market data and analytics are derived from primary and secondary ...
(Date:2/17/2017)... ... 17, 2017 , ... Academy of Model Aeronautics (AMA), the ... of unmanned aircraft systems (UAS), are launching a joint program to promote safe ... support educational outreach efforts. , AMA and DJI will collaborate on other potential ...
(Date:2/16/2017)... 16, 2017  ImMAGE Biotherapeutics (OTCMKTS: IMMG), an early-stage biotechnology ... a better treatment for triple negative breast cancer (TNBC), announced ... France program. The YEi Start in ... to help entrepreneurs grow their business in France ... American companies selected to complete an intensive one week immersion ...
(Date:2/16/2017)... -- Research and Markets has announced the ... report to their offering. ... The study scope ... plasmids, chassis organisms, synthetic cells, production systems), enabling technologies ... and specialty media) and enabled technologies (biofuels, chemicals, pharmaceuticals, ...
Breaking Biology Technology: