Navigation Links
Bioactive cement scaffold may improve bone grafts

A new technology for implants that may improve construction or repair of bones in the face, skull and jaw, has been developed by researchers from the American Dental Association Foundation (ADAF) and the National Institute of Standards and Technology (NIST).

Described in recent and upcoming journal articles,* the new technology provides a method for making scaffolds for bone tissue. The scaffold is seeded with a patient's own cells and is formed with a cement paste made of minerals also found in natural bone. The paste is mixed with beads of a natural polymer (made from seaweed) filled with bone cells. The paste is shaped or injected into a bone cavity and then allowed to harden with the encapsulated cells dispersed throughout the structure. The natural polymer beads gradually dissolve when exposed to the body's fluids, creating a scaffold that is filled by the now released bone cells.

The cement, a calcium phosphate material, is strengthened by adding chitosan, a biopolymer extracted from crustacean shells. The implant is further reinforced to about the same strength as spongy natural bone by covering it with several layers of a biodegradable fiber mesh already used in clinical practice.

"Bone cells are very smart," says Hockin Xu, of the ADAF and principal investigator for the project. "They can tell the difference between materials that are bioactive compared to bioinert polymers. Our material is designed to be similar to mineral in bone so that cells readily attach to the scaffold." The researchers used mouse bone cells in their experiments, but in practice surgeons would use cells cultured from patient samples. In addition to creating pores in the hardened cement, the natural polymer beads protect the cells during the 30 minutes required for the cement to harden. Future experiments will develop methods for improving the material's mechanical properties by using smaller encapsulating beads that biodegrade at a predictable rate.

NIST and the American Dental Association Foundation have conducted cooperative research on dental and medical materials since 1928. ADAF researchers focus on development of new dental materials, while NIST specializes in the development of improved technologies and methods for measuring materials properties.


'"/>

Source:National Institute of Standards and Technology (NIST)


Related biology news :

1. Advancements In Genomics Foster Deep Sea Discoveries
2. Computer models aid understanding of antibody-dependent enhancement in spread of dengue fever
3. Findings advance use of adult stem cells for replacement bone
4. Genes may determine success of hip replacement surgery
5. Percutaneous aortic valve replacement safe, successful in high-risk patients
6. Tiny scaffolding allows stem cells to become working fat cells
7. Microscopic scaffolding offers a simple solution to treating skin injuries
8. Bedsores and bald hides: Novel roles revealed for a scaffolding protein
9. MIT creates 3-D scaffold for growing stem cells
10. Woven scaffolds could improve cartilage repair
11. Tissue engineered scaffolding allows reproduction of cartilage tissue
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/31/2016)... 31, 2016  Genomics firm Nabsys has completed a ... Barrett Bready , M.D., who returned to the company ... technical leadership team, including Chief Technology Officer, John ... Steve Nurnberg and Vice President of Software and Informatics, ... Dr. Bready served as CEO of Nabsys ...
(Date:3/22/2016)... Ontario , PROVO and ... Newborn Screening Ontario (NSO), which operates the ... for molecular testing, and Tute Genomics and UNIConnect, ... management technology respectively, today announced the launch of a ... next-generation sequencing (NGS) testing panel. NSO ...
(Date:3/15/2016)... -- --> --> According ... "Digital Door Lock Systems Market - Global Industry Analysis, Size, ... digital door lock systems market in terms of revenue was ... to grow at a CAGR of 31.8% during the period ... (MSMEs) across the world and high industrial activity driving inclusive ...
Breaking Biology News(10 mins):
(Date:5/3/2016)... ... 2016 , ... Leading CEOs from biotech, pharmaceutical, and healthcare ... 1st at The Four Seasons Hotel Boston. , The Boston CEO Conference is ... access to key decision makers who influence deal making and investment. Attendees gain ...
(Date:5/3/2016)... THE WOODLANDS, Texas , May 3, 2016 /PRNewswire/ ... board certified plastic surgeon in The Woodlands, ... technology that destroys 24 percent of treated fat cells ... men and woman. Close to 90 percent of Americans ... effective treatment options. Nonsurgical fat reduction procedures are a ...
(Date:5/2/2016)... ... ... StarNet Communications Corp, ( http://www.starnet.com/ ) a leading publisher of remote Linux and ... its flagship X-Win32 PC X server. The new modules enable X-Win32 to safely ... encrypted SSH. , Traditionally, users of PC X servers deploy the XDMCP protocol to ...
(Date:4/29/2016)... , April 29, 2016 ... Transparency Market Research "Separation Systems for Commercial Biotechnology ... Trends, and Forecast 2015 - 2023", the separation ... US$ 10,665.5 Mn in 2014 and is projected ... 2015 to 2023 to reach US$ 19,227.8 Mn ...
Breaking Biology Technology: