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Big hips, big belly? It's in your genes, Joslin-led study shows

Young adults with high levels of antibodies against the Epstein-Barr virus, the virus that most often causes mononucleosis, may be more likely to develop multiple sclerosis 15 to 20 years later, according to a study posted online today that will appear in the June 2006 print issue of Archives of Neurology, one of the JAMA/Archives journals.

Researchers have long suspected that external factors may influence the risk for multiple sclerosis (MS), a chronic autoimmune disease that affects the central nervous system, according to background information in the article. Some studies have suggested that the Epstein-Barr virus, which affects up to 96 percent of Americans by the time they reach age 35 to 40 years, may play a role.

Gerald N. DeLorenze, Ph.D., Kaiser Permanente Division of Research, Oakland, Calif., and colleagues examined the records of patients who joined a health plan between 1965 and 1974, when they were an average of 32.4 years old. The patients had undergone multiple examinations, answered questions about their health and behaviors and submitted blood samples, which were processed and stored at cold temperatures. Between 1995 and 1999, the researchers searched medical records maintained by the health plan and selected 42 individuals with MS who had blood samples in storage. Three people with blood samples but without MS were matched to each MS patient by age, sex and date of blood collection. The blood samples of all participants were then analyzed to determine the levels of antibodies against the Epstein-Barr virus. Measuring antibodies, proteins produced by the body to fight infection, is one way to determine exposure to or presence of a particular virus in a person's body.

The 36 women and six men who developed MS had their first symptoms at an average age of 45 years and an average of 15 years after their blood was collected. The average concentration of anti–Epstein-Barr virus antibodies was significantly higher among in
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Source:Joslin Diabetes Center


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