Navigation Links
Big hips, big belly? It's in your genes, Joslin-led study shows

Young adults with high levels of antibodies against the Epstein-Barr virus, the virus that most often causes mononucleosis, may be more likely to develop multiple sclerosis 15 to 20 years later, according to a study posted online today that will appear in the June 2006 print issue of Archives of Neurology, one of the JAMA/Archives journals.

Researchers have long suspected that external factors may influence the risk for multiple sclerosis (MS), a chronic autoimmune disease that affects the central nervous system, according to background information in the article. Some studies have suggested that the Epstein-Barr virus, which affects up to 96 percent of Americans by the time they reach age 35 to 40 years, may play a role.

Gerald N. DeLorenze, Ph.D., Kaiser Permanente Division of Research, Oakland, Calif., and colleagues examined the records of patients who joined a health plan between 1965 and 1974, when they were an average of 32.4 years old. The patients had undergone multiple examinations, answered questions about their health and behaviors and submitted blood samples, which were processed and stored at cold temperatures. Between 1995 and 1999, the researchers searched medical records maintained by the health plan and selected 42 individuals with MS who had blood samples in storage. Three people with blood samples but without MS were matched to each MS patient by age, sex and date of blood collection. The blood samples of all participants were then analyzed to determine the levels of antibodies against the Epstein-Barr virus. Measuring antibodies, proteins produced by the body to fight infection, is one way to determine exposure to or presence of a particular virus in a person's body.

The 36 women and six men who developed MS had their first symptoms at an average age of 45 years and an average of 15 years after their blood was collected. The average concentration of anti–Epstein-Barr virus antibodies was significantly higher among in dividuals who had developed MS than among those who hadn't--those with four times the level of antibodies were approximately twice as likely to develop MS. The elevated levels became evident between 15 and 20 years before patients first experienced the neurological symptoms of MS and remained higher afterward, the researchers reported.

Researchers don't yet understand how the Epstein-Barr virus causes the body to attack its own central nervous system, as it does in MS. "The mounting evidence that relates Epstein-Barr virus infection to other autoimmune diseases, particularly systemic lupus erythematosus (lupus), suggests that Epstein-Barr virus may have a broad role in predisposing to autoimmunity," or failure of the immune system to recognize the body's own tissues, the authors conclude. "A fine understanding of the mechanisms that connect Epstein-Barr virus infection to MS is important because it will provide the basis for the translation of this epidemiologic finding into new ways to treat and prevent MS."


'"/>

Source:Joslin Diabetes Center


Related biology news :

1. Environment, not genes, key in family relationships
2. Scientists identify 36 genes, 100 neuropeptides in honey bee brains
3. Bioartificial kidney under study at MCG
4. W.M. Keck Foundation funds study of friendly microbes
5. Yellowstone microbes fueled by hydrogen, according to U. of Colorado study
6. Genome-wide mouse study yields link to human leukemia
7. Clam embryo study shows pollutant mixture adversely affects nerve cell development
8. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
9. Same mutation aided evolution in many fish species, Stanford study finds
10. Sequencing of marine bacterium will help study of cell communication
11. Genetically modified rice in China benefits farmers health, study finds
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/22/2016)...  The American College of Medical Genetics and Genomics was ... as one of the fastest-growing trade shows during the Fastest ... in Las Vegas . ... in each of the following categories: net square feet of ... attendees. The 2015 ACMG Annual Meeting was ranked 23 out ...
(Date:6/20/2016)... -- Securus Technologies, a leading provider of civil ... investigation, corrections and monitoring announced that after exhaustive ... the final acceptance by all three (3) Department ... (MAS) installed. Furthermore, Securus will have contracts for ... October, 2016. MAS distinguishes between legitimate wireless device ...
(Date:6/9/2016)... , June 9, 2016 ... deploy Teleste,s video security solution to ensure the safety of ... during the major tournament Teleste, an ... systems and services, announced today that its video security solution ... to back up public safety across the country. The ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... Chapel Hill, N.C. (PRWEB) , ... June 27, ... ... of U.S. commercial operations for Amgen, will join the faculty of the ... will serve as adjunct professor of strategy and entrepreneurship at UNC Kenan-Flagler, with ...
(Date:6/24/2016)... 2016 Epic Sciences unveiled a liquid ... to PARP inhibitors by targeting homologous recombination deficiency ... new test has already been incorporated into numerous ... types. Over 230 clinical trials are ... including PARP, ATM, ATR, DNA-PK and WEE-1. Drugs ...
(Date:6/23/2016)... ... June 23, 2016 , ... UAS LifeSciences, one ... of their brand, UP4™ Probiotics, into Target stores nationwide. The company, which has ... add Target to its list of well-respected retailers. This list includes such fine ...
(Date:6/23/2016)... June 23, 2016 Houston Methodist Willowbrook ... Cy-Fair Sports Association to serve as their official ... Houston Methodist Willowbrook will provide sponsorship support, athletic ... with association coaches, volunteers, athletes and families. ... Cy-Fair Sports Association and to bring Houston Methodist ...
Breaking Biology Technology: