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Beyond the DNA: Chemical signatures reveal genetic switches in the genome

it is altered in disease. "The beauty of this approach is that it utilizes a chemical signature present on histones but not DNA. Existing methods to predict enhancers rely on the DNA sequence alone, but these are inadequate because we have an incomplete understanding of the sequence features that identify enhancers. The elucidation of a common histone modification signature will enable scientists to quickly identify enhancers and promoters for a gene, which will lead in turn to rapid identification of factors that control its expression." This method might also be used to identify the disruptions in gene networks that occur during cancer progression, says Dr. Ren, which might lead to novel strategies for cancer diagnosis.


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Source:Ludwig Institute for Cancer Research


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