Navigation Links
Beyond lithium for bipolar disorder

While lithium treatment has proven to be a godsend for many of the two million Americans with bipolar disorder, it is not without its downside. People on the drug may develop hypothyroidism, tremors, cognitive impairment, and excessive thirst and urination and gain weight.

However, better treatments for bipolar disorder depend on a better understanding of the still-mysterious mechanism by which lithium damps the highs and lows of the disorder. Now, researchers led by Philip Brandish of Merck & Co., Inc., and Edward Scolnick of the Broad Institute (formerly of Merck and Co., Inc.) have identified genes whose activity appears to be switched on by lithium, suggesting more direct targets for drugs to treat the disorder.

Lithium is known to inhibit the production of an important cellular switch, called inositol monophosphate, so the researchers set out to find genes that were activated by this inhibition. They treated slices of rat brain with lithium chloride as well as a chemical that depletes inositol. The also treated other slices with the two chemicals, but added inositol.

The researchers used DNA microarrays--so-called "gene chips"--to detect genes that were unequivocally activated when inositol was depleted in the brain slices.

They discovered several genes that they concluded "suggest new directions toward the treatment of bipolar disorder."

The behavior of one such activated gene, called GPR88, has been found to be associated with a rat model of mania, they said. This gene codes for a protein that is an "orphan receptor"--that is, its cellular function in sensing external chemical signals is unknown.

The researchers also found that the gene called AD-CYAP1 was upregulated in the treated brain slices. This gene codes for a signaling molecule called PACAP in the brain and is known to be close to a chromosomal region that genetic studies have shown to be associated with a higher risk of bipolar disorder.

PAC
'"/>

Source:Cell Press


Page: 1 2

Related biology news :

1. Beyond genes: Lipid helps cell wall protein fold into proper shape
2. Beyond the book: Software automates access to brain atlases
3. Beyond the DNA: Chemical signatures reveal genetic switches in the genome
4. Clock molecules sensitivity to lithium sheds light on bipolar disorder
5. New gene linked to bipolar disorder
6. Lithium builds gray matter in bipolar brains, UCLA study shows
7. Genetic roots of bipolar disorder revealed by first genome-wide study of illness
8. Mouse brain tumors mimic those in human genetic disorder
9. Iron exporter revealed that may explain common human disorder
10. Pinpointing the cause of a neurodegenerative disorder
11. Researchers track down cause of a disfiguring bone disorder
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Beyond lithium for bipolar disorder

(Date:6/16/2015)... Fingerprint Cards (FPC) raises the revenue guidance for ... at least 340 MSEK to that it will amount to ... growth and orders received the revenue guidance for 2015 is ... will exceed 1,500 MSEK to an updated guidance that revenue ... Due to receipt of orders of touch fingerprint sensors with ...
(Date:6/12/2015)... , June 12, 2015  Securus Technologies, ... technology solutions for public safety, investigation, corrections and ... its patent to electronically capture, analyze and identify ... facial recognition methods. This system can: ... by an enrollment and subsequent sign-on process is ...
(Date:6/9/2015)... -- Research and Markets  ( http://www.researchandmarkets.com/research/xsgs2s/gesture ) has ... & Touchless Sensing Market by Technology (Touch-based & ... (Biometric & Sanitary Equipment) & by Geography - ... offering. The total gesture recognition and ... 23.55 Billion by 2020 at a high CAGR ...
Breaking Biology News(10 mins):Fingerprint Cards Raises the Revenue Guidance for Q2 2015 and for the Full Year 2015 2Fingerprint Cards Raises the Revenue Guidance for Q2 2015 and for the Full Year 2015 3Securus Announces Patent Issued for Authorized Presence Verification During Video Visitation 2Global Gesture Recognition & Touchless Sensing (Technology, Application & Products) Market 2015-2020 2
... gene responsible for controlling a first key step in the ... the journal Nature tomorrow (Thursday 27 October 2005). , The ... place once a sperm enters an egg, giving it a ... animals. , The absence or mutation of this gene in ...
... to last year's groundbreaking toxicological study on water-soluble ... and Environmental Nanotechnology (CBEN) find that water-soluble carbon ... Moreover, the research finds that nanotubes, like buckyballs, ... , The findings come from the first toxicological ...
... the University of California, San Diego that appears in the ... of the species Uca crenulata may check out 100 or ... on a mate. , “As far as I know, no ... as the California fiddler crab,?said Catherine deRivera, who conducted the ...
Cached Biology News:Scientists unpick genetics of first 15 minutes of life 2Modifications render carbon nanotubes nontoxic 2Modifications render carbon nanotubes nontoxic 3Biologist Discovers What May Be World’s ‘Pickiest?Mates 2Biologist Discovers What May Be World’s ‘Pickiest?Mates 3
(Date:7/2/2015)... GLEN ELLYN, Ill. , July 2, 2015 /PRNewswire-USNewswire/ ... and Colton Eakins are gaining invaluable real-world ... Institute of Technology this summer. The students ... Dr. Jeff Wereszczynski,s research group at IIT. ... Professors Dr. Tom Carter , Physics; Dr. ...
(Date:7/1/2015)... ... July 01, 2015 , ... It is now possible to separate two common ... emission computed tomography (SPECT) according to researchers from Amen Clinics, UCLA, Thomas Jefferson ... scans and is believed to be the largest brain imaging study ever, will be ...
(Date:7/1/2015)... , July 1, 2015   Neuraltus Pharmaceuticals, ... development of groundbreaking drugs to treat neurodegenerative diseases ... that Robert G. Miller , M.D., Director of ... Health,s California Pacific Medical Center in San Francisco, has ... for $1.5 million to help fund a Phase ...
(Date:7/1/2015)... ... July 01, 2015 , ... Apex Therapeutics announced today that company CEO, ... PA. , The presentation took place on Tuesday, June 16 and provided ... development of APX3330 for the treatment of pancreatic cancer. A copy of the ...
Breaking Biology Technology:COD Students Participate in Prestigious Summer Internships 2Brain Scans Can Tell Post-Traumatic Stress Disorder and Traumatic Brain Injury Apart According to New Research by Amen Clinics 2Brain Scans Can Tell Post-Traumatic Stress Disorder and Traumatic Brain Injury Apart According to New Research by Amen Clinics 3Brain Scans Can Tell Post-Traumatic Stress Disorder and Traumatic Brain Injury Apart According to New Research by Amen Clinics 4Investigator to Receive $1.5 Million Grant from the ALS Association to Help Fund Confirmatory Phase 2 Study of Neuraltus Pharmaceuticals' NP001 2Investigator to Receive $1.5 Million Grant from the ALS Association to Help Fund Confirmatory Phase 2 Study of Neuraltus Pharmaceuticals' NP001 3Investigator to Receive $1.5 Million Grant from the ALS Association to Help Fund Confirmatory Phase 2 Study of Neuraltus Pharmaceuticals' NP001 4Apex Therapeutics Presented Company Overview at This Year’s BIO International Convention in Philadelphia, PA 2
... Canary Foundation, a,nonprofit organization that funds research in early ... Sam Gambhir, has,been elected as a new member of ... one of the highest honors in the fields of ... National Academy of,Sciences, serves as adviser to the nation ...
... MOUNTAIN VIEW, Calif., Oct. 21 An ... difficult to treat allures clinicians,to the approach of ... potential, stem cell therapies are believed to treat ... at a fast pace; however,both adult and embryonic ...
... Findings confirm that NanoBio,s nanoemulsion technology is effective when ... used in therapeutic applications and vaccines, ... announced,today that it will present compelling new data in ... preclinical development programs,in onychomycosis, herpes labialis, cystic fibrosis and ...
Cached Biology Technology:Canary Foundation's Dr. Sanjiv Sam Gambhir Elected to the National Academies Institute of Medicine 2Innovation and Strong Therapeutic Potential Seen in Adult Stem Cells, According to Frost & Sullivan 2Innovation and Strong Therapeutic Potential Seen in Adult Stem Cells, According to Frost & Sullivan 3NanoBio to Announce Key Clinical and Preclinical Data in Nine Presentations at ICAAC/IDSA 2008 2
EnzChek cellulase substrate *blue fluorescent, 339/452...
Homo sapiens 4-aminobutyrate aminotransferase Antigen: Recombinant Protein...
... 0.5-10 Kb RNA Ladder is suitable for sizing single-stranded ... glyoxal or formaldehyde agarose gels. The ladder consists of ... 3 4 6 8 and 10 kb) to simplify ... than the other bands allowing easy orientation and identification ...
Human DCIR/CLEC4A Phycoerythrin MAb (Clone 216110)...
Biology Products: