Navigation Links
Beyond genes: Lipid helps cell wall protein fold into proper shape

A protein that provides a vital passage through a bacterium's outer cell wall will misfold and malfunction if that wall is built of the 'wrong' material, scientists at The University of Texas Medical School at Houston report in a finding that has long-term implications for understanding diseases caused by misfolded proteins such as cystic fibrosis, Alzheimer's disease, and mad cow disease.

The paper in today's Journal of Biological Chemistry by Professor of Biochemistry and Molecular Biology William Dowhan, Ph.D., and colleagues shows that phospholipids, which make up the permeable barrier of cell membranes, play a direct role in the folding of membrane proteins ?proteins that penetrate the membrane or bind to either side of it.

"What we've demonstrated again is that it's not just a membrane protein's genetically determined sequence that dictates how it folds so that it can function properly. Its lipid environment also plays a role," Dowhan said. "People used to assume that specific lipids made no difference."

In the JBC paper, Dowhan and colleagues looked at how a protein called GabP, which transports an amino acid across the membrane of the bacterium E. coli, is affected by the presence of a phospholipid named phosphatidylethanolamine, or PE for short.

Phospholipids, unlike their fatty acid and cholesterol cousins, include a phosphate group that spurs them to form a bilayer with water-friendly outer layers sandwiching an impermeable water-unfriendly inner layer that defines the outer surface of cells. Transport of nutrients and waste material across the cell membrane is then governed by the specific proteins associated with it.

In a strain of E. coli lacking PE, the GabP protein misfolded, with two areas of the protein inverting from their normal structure. The PE-lacking protein's amino acid transfer rate plummeted to nearly zero, falling 99 percent compared to the transfer rate in unaltered E. coli with PE.

GabP is
'"/>

Source:University of Texas Health Science Center at Houston


Page: 1 2 3

Related biology news :

1. Beyond lithium for bipolar disorder
2. Beyond the book: Software automates access to brain atlases
3. Beyond the DNA: Chemical signatures reveal genetic switches in the genome
4. Its in the genes: Study opens door to new treatment of the blues
5. Lipids get new comprehensive classification system
6. Jumping gene helps explain immune systems abilities
7. Protein helps regulate the genes of embryonic stem cells
8. Scientists reveal the shape of a protein that helps retroviruses break into cells
9. Thai spice helps cut blood sugar swings
10. Chemists synthesize molecule that helps body battle cancers, malaria
11. Ancient DNA helps clarify the origins of two extinct New World horse species
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Beyond genes Lipid helps cell wall protein fold into proper shape

(Date:4/17/2015)... Increasing adoption in ... to drive biometric systems market in ... According to a recently released TechSci Research ... biometric systems market in Saudi Arabia ... CAGR of over 22% through 2020. The market ...
(Date:4/13/2015)... , April 13, 2015 ... TechSci Research, "Global Biometrics Market Forecast & Opportunities, 2020", ... a CAGR of around 14% till 2020. The ... for large scale implementation and review of biometric ... launch of new products with greater efficiency, are ...
(Date:4/9/2015)... 2015 Synaptics Inc. (NASDAQ: SYNA ), a ... it will report financial results for the third quarter ... the close of market. The company will host a ... p.m. PT (5:00 p.m. ET), during which management may ... the live call, analysts and investors should dial 888-438-5524 ...
Breaking Biology News(10 mins):Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 2Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 3Global Biometrics Market to Cross US$ 21 Billion by 2020: TechSci Research 2Synaptics to Report Third Quarter Results on April 23 2
... MA A new study by Harvard School of Public ... lipoprotein (HDL) cholesterol, the so-called "good" cholesterol, may not protect ... harmful. , This is the first study to show ... on the surface of HDL cholesterol may increase the risk ...
... ORANGE, Calif. A groundbreaking study lead by ... of American college students will be published in ... top-tier international journal in reproductive biology. It is ... undergraduate university students. In the USA, the postponement of ...
... suggests that population declines to be observed during the ... recent climate warming on mountain plants. A European team ... Conservation Biology, Vegetation and Landscape Ecology of the University ... migration of mountain plants which explicitly takes population dynamic ...
Cached Biology News:Some HDL, or 'good' cholesterol, may not protect against heart disease 2New study published on fertility awareness among American university students 2European mountain plant population shows delayed response to climate change 2
(Date:5/6/2015)... (PRWEB) May 06, 2015 ... a type of nanomaterial with diameter ranging between ... in the global nanophotonics materials market. The unique ... dots due to quantum confinement effect render the ... wide range of scientific, technological, and commercial applications. ...
(Date:5/6/2015)... May 6, 2015   University of Maryland (UM) ... today the signing of an exclusive option by Biomecite ... (UMB) to develop diagnostics to detect inflammatory bowel diseases ... (CD). Drs. Florian Fricke and James ... with the University of Maryland School of Medicine,s Institute ...
(Date:5/6/2015)... Fla. , May 6, 2015  Oxis Biotech, ... Inc. OTC: OXIS, OXI.PA, announced today that Cassian ... Division of Cancer Medicine at the University of Texas ... Dr. Yee is also Professor, Department of Immunology, Division ... Center for Cancer Immunology Research at the University of ...
(Date:5/6/2015)... , May 6, 2015 ... membrane specialist, announced today that it has signed an ... Ethanol, Inc. (Nasdaq: PEIX ) for the delivery of an industrial ... reduce the consumption of water, energy and ... output. This project is fully ...
Breaking Biology Technology:Expanding Applications & Full-Scale Commercialization to Drive the Global Quantum Dots Market, According to a New Report by Global Industry Analysts, Inc. 2Expanding Applications & Full-Scale Commercialization to Drive the Global Quantum Dots Market, According to a New Report by Global Industry Analysts, Inc. 3Biomecite Diagnostics Signs Option Agreement with UM Baltimore to Develop Tools to Detect Inflammatory Bowel Diseases 2Biomecite Diagnostics Signs Option Agreement with UM Baltimore to Develop Tools to Detect Inflammatory Bowel Diseases 3Oxis Biotech Appoints Cassian Yee, M.D. To Its Scientific Advisory Board 2Oxis Biotech Appoints Cassian Yee, M.D. To Its Scientific Advisory Board 3Whitefox Signs Agreement With Pacific Ethanol Inc. 2
... KONG, June 3, 2011 /PRNewswire-Asia-FirstCall/ -- China Cord Blood Corporation ... plan to release financial results for the fourth quarter and ... 2011, after market close in the US.   ... ET on Monday, June 13, 2011 to discuss its financial ...
... method for creating single-crystal arrays of the material graphene, ... for silicon in high-performance computers and electronics. The work ... the cover of the June issue of Nature ... that was first fabricated in 2004. Single-crystal arrays of ...
... June 2, 2011 Anthera Pharmaceuticals, Inc. (Nasdaq: ... offer and sell shares of its common stock in an ... a 30-day option to purchase up to an additional 15% ... offering to cover over-allotments, if any.  Citi and Leerink Swann ...
Cached Biology Technology:China Cord Blood Corporation to Report Fourth Quarter and Full Year Fiscal 2011 Financial Results 2University of Houston develops method for creating single-crystal arrays of graphene 2Anthera Pharmaceuticals Announces Proposed Public Offering of Common Stock 2Anthera Pharmaceuticals Announces Proposed Public Offering of Common Stock 3
karyopherin alpha2 (2G7)...
50 assays. Provides an easy system for rapid separation of cytosol and particulate fractions that are compatiable with downstream studies....
Eliminate electrical interference from any analog signal, without filtering. Ideal for electrophysiology applications like EKG, EMG, and EEGs. Removes 50/60hz noise and harmonics caused by grounding ...
... 10. *SizeSep 400 Spun Columns: For rapid ... in length. - ... distilled water containing 0.15% Kathon CG/IcP Biocide. ... pairs. *Extremely useful in the construction ...
Biology Products: