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Bevacizumab Combined With Chemotherapy Improves Progression-Free Survival for Patients With Advanced Breast Cancer

* that already has been approved for metastatic colorectal cancer in combination with chemotherapy, is designed to bind to and inhibit vascular endothelial growth factor (VEGF). VEGF is a protein that plays a critical role in tumor angiogenesis.

“It is noteworthy that a previous company-sponsored trial in patients who received prior chemotherapy for advanced disease did not show a benefit with bevacizumab in combination with capecitabine, a different chemotherapy agent,?said JoAnne Zujewski, M.D., who heads breast cancer trials for NCI’s Cancer Therapy Evaluation Program. “It is fortunate that ECOG, assisted by multiple other NCI-sponsored Cooperative Groups, persisted with this trial in patients with newly diagnosed advanced breast cancer, as the agent is clearly active in this setting.?/p>

An estimated 211,240 women will be diagnosed with breast cancer in the United States in 2005. Breast cancer is the most commonly diagnosed cancer in women and the second leading cause of cancer-related death in women in this country. An estimated 40,110 deaths from female breast cancer will occur in 2005 in the United States, accounting for about 15 percent of all cancer-related deaths in women in the nation.


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Source:NIH


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