Navigation Links
Better insight into brain anatomical structures

Magnetic resonance imaging is a very effective method for revealing anatomical details of soft tissues. Contrast agents can help to make these images even clearer and allow physiological processes to be followed in real time. Conventional gadolinium complexes currently used as MRI contrast agent cannot reveal anatomic structures. As reported in the journal Angewandte Chemie, Korean researchers led by Jung Hee Lee at Samsung Medical Center and Taeghwan Hyeon at Seoul National University have now developed a new MRI contrast agent using manganese oxide nanoparticles that produces images of the anatomic structures of mouse brain which are as clear as those obtained by histological examination.

Magnetic resonance images after injection of the manganese oxide nanoparticles gave a view into different areas of the mouse brains—in excellent resolution. "We have developed the first truly biocompatible MRI contrast agent for anatomical brain imaging," Lee and Hyeon point out. "With this agent, we are able to get high-contrast views of the anatomical details of live mouse brain." The researchers hope that their new contrast agent will allow better research and diagnosis of brain diseases involving the CNS (central nervous system), such as Alzheimer's disease, Parkinson's disease, strokes, and tumors.

Furthermore, the Korean team was able to attach antibodies to the manganese oxide nanoparticles. These antibodies recognize and specifically bind to receptors on the surface of breast cancer cells. In mouse brains with breast cancer metastases, the tumors were clearly highlighted by the antibody-coupled contrast agent. The same principle should allow other disease-related changes or physiological systems to be visualized by using the appropriate antibodies.


'"/>

Source:John Wiley & Sons, Inc.


Page: 1

Related biology news :

1. Institute for Systems Biology Symposium Addresses Need for Better Computational Tools
2. Protein Discovery Could Unlock The Secret To Better TB Treatment
3. Computational Tool Predicts How Drugs Work In Cells, Advancing Efforts To Design Better Medicines
4. Opiates Better Than Sedatives For Treating Newborns In Withdrawal
5. Newly Discovered Role for Heart Response Enzyme May Yield Better Heart Failure Therapy
6. Better beetle sought for salt cedar control
7. Better sludge through metagenomics
8. Better assessment of transfusions could save blood
9. Better health twice as likely for nonsmokers who live and work with smoking restrictions
10. New insight into people who see colors in letters and numbers
11. Alaskan puzzles, monitoring provide insight about North Pacific salmon runs
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/23/2017)... ITHACA, N.Y. , June 23, 2017 ... a leader in dairy research, today announced a new ... help reduce the chances that the global milk supply ... this dairy project, Cornell University has become the newest ... Food Supply Chain, a food safety initiative that includes ...
(Date:5/23/2017)... , May 23, 2017  Hunova, the first robotic gym for ... has been officially launched in Genoa, Italy . The ... and the USA . The technology was ... the market by the IIT spin-off Movendo Technology thanks to a 10 ... Multimedia News Release, please click: ...
(Date:5/16/2017)...   Bridge Patient Portal , an enterprise ... EMR Systems , an electronic medical record solutions ... established a partnership to build an interface between ... Centricity™ products, including Centricity Practice Solution (CPS), Centricity ... new integrations will allow healthcare delivery networks using ...
Breaking Biology News(10 mins):
(Date:8/15/2017)... ... August 15, 2017 , ... Kenall, a leader ... designed to stay tightly sealed and perform efficiently for years. The downlights are ... listings just aren't enough, such as: hospitals; behavioral health facilities; cleanrooms; containment areas; ...
(Date:8/15/2017)... ... August 15, 2017 , ... JULABO USA introduces its ... new website makes it easy to navigate through the site whether you’re in ... detailed product information, educational industry content and visit the company’s social media accounts, ...
(Date:8/14/2017)... , ... August 14, 2017 , ... The Conference ... event, which will take place on September 6, 2017 at the Marriott Copley ... , Head of Experimental Medicine, Informatics, and Regulatory Strategy, Pfizer Innovative Research Lab, Pfizer, ...
(Date:8/11/2017)... ... August 11, 2017 , ... Algenist continues to disrupt the skincare industry ... never before. , Collagen is the key structural element skin needs to maintain ... which include: , First to market with proprietary collagen ...
Breaking Biology Technology: