Navigation Links
Better insight into brain anatomical structures

Magnetic resonance imaging is a very effective method for revealing anatomical details of soft tissues. Contrast agents can help to make these images even clearer and allow physiological processes to be followed in real time. Conventional gadolinium complexes currently used as MRI contrast agent cannot reveal anatomic structures. As reported in the journal Angewandte Chemie, Korean researchers led by Jung Hee Lee at Samsung Medical Center and Taeghwan Hyeon at Seoul National University have now developed a new MRI contrast agent using manganese oxide nanoparticles that produces images of the anatomic structures of mouse brain which are as clear as those obtained by histological examination.

Magnetic resonance images after injection of the manganese oxide nanoparticles gave a view into different areas of the mouse brains—in excellent resolution. "We have developed the first truly biocompatible MRI contrast agent for anatomical brain imaging," Lee and Hyeon point out. "With this agent, we are able to get high-contrast views of the anatomical details of live mouse brain." The researchers hope that their new contrast agent will allow better research and diagnosis of brain diseases involving the CNS (central nervous system), such as Alzheimer's disease, Parkinson's disease, strokes, and tumors.

Furthermore, the Korean team was able to attach antibodies to the manganese oxide nanoparticles. These antibodies recognize and specifically bind to receptors on the surface of breast cancer cells. In mouse brains with breast cancer metastases, the tumors were clearly highlighted by the antibody-coupled contrast agent. The same principle should allow other disease-related changes or physiological systems to be visualized by using the appropriate antibodies.


'"/>

Source:John Wiley & Sons, Inc.


Page: 1

Related biology news :

1. Institute for Systems Biology Symposium Addresses Need for Better Computational Tools
2. Protein Discovery Could Unlock The Secret To Better TB Treatment
3. Computational Tool Predicts How Drugs Work In Cells, Advancing Efforts To Design Better Medicines
4. Opiates Better Than Sedatives For Treating Newborns In Withdrawal
5. Newly Discovered Role for Heart Response Enzyme May Yield Better Heart Failure Therapy
6. Better beetle sought for salt cedar control
7. Better sludge through metagenomics
8. Better assessment of transfusions could save blood
9. Better health twice as likely for nonsmokers who live and work with smoking restrictions
10. New insight into people who see colors in letters and numbers
11. Alaskan puzzles, monitoring provide insight about North Pacific salmon runs
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/16/2016)... Dec. 16, 2016   IdentyTechSolutions America LLC ... products and solutions and a cutting-edge manufacturer of ... it is offering seamless, integrated solutions that comprise ... products. The solutions provide IdentyTech,s customers with combined ... facilities from crime and theft. "We ...
(Date:12/16/2016)... -- The global wearable medical device market, in terms of value, ... 5.31 billion in 2016, at a CAGR of 18.0% during the ... ... medical devices, launch of a growing number of smartphone-based healthcare apps ... providers, and increasing focus on physical fitness. Furthermore, ...
(Date:12/15/2016)... Dec. 15, 2016   WaferGen Bio-systems, Inc. ... technology company, announced today that on December 13, 2016, ... of The Nasdaq Stock Market LLC which acknowledged that, ... of WaferGen,s common stock had been at $1.00 or ... regained compliance with Listing Rule 5550(a)(2) of the Nasdaq ...
Breaking Biology News(10 mins):
(Date:1/18/2017)... (PRWEB) , ... January 18, 2017 , ... ... more and more E&L expertise. Within Albany Molecular Research, Inc. (AMRI), the scientific ... the past year and is planned for further growth in 2017. Extractable & ...
(Date:1/18/2017)... ... January 18, 2017 , ... MYOLYN, which creates medical ... submitted a 510(k) to the FDA, requesting clearance of the MyoCycle Home and ... (FES) technology. , The submission marks a major milestone for the technology ...
(Date:1/18/2017)... ... January 18, 2017 , ... ... SCOPE Summit for Clinical Ops Executives (Hyatt Regency Miami, January 24-26). DrugDev will ... vital clinical research issues such as trial performance metrics, patient enrollment diversity, protocol ...
(Date:1/18/2017)... ... January 18, 2017 , ... uBiome, ... latest paper by its Science Editor, Dr. Elisabeth Bik, in the December 2016 ... Dr. Bik joined uBiome in October 2016 from her previous position at Stanford ...
Breaking Biology Technology: