Navigation Links
Basic research leads to a novel cancer therapy

Cancer researcher Professor Axel Ullrich, a director at the Max Planck Institute of Biochemistry in Martinsried, Germany, already showed at the beginning of the 1990s that blocking blood vessel development in a tumour slows down its growth, and shrinks its tissue. This fundamental principle led to the development of SUTENT®, whose active ingredient is Sunitinib. SUTENT® was recently approved for clinical use in the United States, and it is expected to be brought onto the German market this year.

When particular growth factors are bound to specific receptors on the surface of a cell, this can cause the cell to propagate itself and build certain tissue similar to blood vessels. Worldwide, research into receptors has focused on a special class of proteins, called tyrosine kinases. They are responsible for causing the received signal to be transduced through a long signalling cascade into the nucleus, triggering cell division and multiplication. Signalling cascades are absolutely necessary, if various tissues - like blood vessels, nerve tissue, and connective tissue - are to be built up during the development of an organism and in the process of tissue regeneration.

Research has focussed on these tumour cell signalling cascades, because in cancers they are often disturbed. If there were a way to block growth factors, or the receptors on the cellular surface from tumour cells, that could lead to targeted therapies against cancers. Already in the 1980s, cancer researcher Axel Ullrich, then a scientist at Genentech (USA), working with colleagues in the UK and Israel, succeeded in describing the structure and function of a receptor for epidermal growth factor (EGF). Since then, tyrosine kinases and various growth factors have been at the focus of research and development of therapies against tumours.

Also, over a decade ago, a team led by Ullrich discovered that by interrupting the oxygen and nutrient supply to tumour cells, it is possible to inhibit
'"/>

Source:Max-Planck-Gesellschaft


Page: 1 2 3 4

Related biology news :

1. Distributed Basic Local Alignment Search Toolkit (W.ND-BLAST)
2. Basic work on E. coli identifies two new keys to regulation of bacterial gene expression
3. Columbia research lifts major hurdle to gene therapy for cancer
4. U of M researcher examines newly emerging deadly disease
5. NYU researchers simulate molecular biological clock
6. First atlas of key brain genes could speed research on cancer, neurological diseases
7. New research questions basic tenet of neuron function
8. Vital step in cellular migration described by UCSD medical researchers
9. ASU researchers finds novel chemistry at work to provide parrots vibrant red colors
10. UCSD researchers maintain stem cells without contaminated animal feeder layers
11. Why do insects stop breathing? To avoid damage from too much oxygen, say researchers
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Basic research leads novel cancer therapy

(Date:5/24/2013)... After studying noise in one French Quarter neighborhood of ... exceeded municipal ordinances, Annette Hurley, PhD, Assistant Professor of ... Eric Arriaga, a third-year LSUHSC doctor of audiology student, ... own hearing health. Their case study is published online ... Practice Management ., "An important part of an audiologist,s ...
(Date:5/23/2013)... popular fruit, can be made both better-tasting and longer-lasting ... , "Working with GM tomatoes that are different to ... compound, allows us to pinpoint exactly how to breed ... John Innes Centre. , The research could also lead ... life characteristics because even higher levels of the compounds ...
(Date:5/23/2013)... discovering the new mechanism by which estrogen suppresses lipid ... a potential new approach toward treating certain liver diseases. ... colleagues believe they are changing long-held views in the ... of the journal Science Signaling . , "The ... has been that only receptors located in the nucleus ...
Breaking Biology News(10 mins):Please do try this at home 2The world's favorite fruit only better-tasting and longer-lasting 2UCI study reveals new mechanism for estrogen suppression of liver lipid synthesis 2
... WASHINGTON The U.S. Environmental Protection Agency (EPA) is ... is releasing a database, called ToxRefDB, which allows scientists ... of toxicity testing results on hundreds of chemicals. ToxRefDB ... "Tens of thousands of chemicals are in commerce ...
... Forget what you know about how diseases are diagnosednew research ... FASEB Journal ( http://www.fasebj.org ) details a noninvasive ground-breaking ... before symptoms can be seen using traditional methods. Even better, ... that they may be reversed before any permanent damage can ...
... Baltimore was hired by Carnegie,s Department of Embryology to wash ... inner city youth. Now as head technician and manager of ... from Johns Hopkins University under her belt, she has authored ... acknowledged for technical assistance on countless others. Genetics researchers in ...
Cached Biology News:US Environmental Protection Agency opens access to chemical information 2New tool helps scientists 'see' molecular signals of eye disease before symptoms arise 2From lab dishwasher to distinguished researcher 2From lab dishwasher to distinguished researcher 3
(Date:5/23/2013)... , May 23, 2013 BioTrends Research ... advisory firms for specialized biopharmaceutical issues, finds that, ... infectious disease specialists reported that in the past ... intentionally delaying treatment) in anticipation of the next ... months ago, when only 6 percent reported that ...
(Date:5/23/2013)... Ill. , May 23, 2013 Z ... providing value-added ingredients to a variety of industries, announced ... in a panel discussion at this year,s National Restaurant ... 20-21, 2013, on behalf of the Research Chefs Association.  ... for Restaurants: The Good, the Bad and the Ugly," ...
(Date:5/23/2013)... DC (PRWEB) May 23, 2013 The ... in STEM industries, Black Data Processing Associates (BDPA), is ... on June 8, 2013. This all-day event will encourage ... and learn the ins and outs from many of ... 3 p.m. at the New Jersey Institute of Technology, ...
(Date:5/23/2013)... SAN DIEGO , May 23, 2013  Verenium ... biotechnology company focused on the development and commercialization of ... , Chief Financial Officer, will present at two ... Mr. Black will present at the Second Annual ... at the Grand Hyatt Hotel in New York City.  ...
Breaking Biology Technology:The Majority of Physicians that Treat Hepatitis C Virus (HCV) Have Begun "Warehousing" and Preparing Their HCV Patients for the Next Generation of HCV Treatments 2The Majority of Physicians that Treat Hepatitis C Virus (HCV) Have Begun "Warehousing" and Preparing Their HCV Patients for the Next Generation of HCV Treatments 3Z Trim's Chef Erin Ryan sits on Expert Panel at NRA Show 2Z Trim's Chef Erin Ryan sits on Expert Panel at NRA Show 3Black Data Processing Associates (BDPA) New Jersey Hosts 10th Annual Families in Technology Day June 8, 2013 2Verenium To Present At Two Upcoming Conferences 2Verenium To Present At Two Upcoming Conferences 3
... There is an old rhetorical saying, "If a tree ... it make a sound?" That same question could be posed ... medical community at large still dismisses Morgellons as some kind ... being ignored doesn,t make their tragedy any less real. One ...
... Associates, Inc. has announced its elite class of 2011 ... Summit and Top Improver awards for clinical achievement and ... Press Ganey, the health care industry,s ... 10,000 health care organizations worldwide to create and sustain ...
... CYPRESS, Calif., Nov. 15, 2011 Quest Diagnostics Incorporated ... of diagnostic testing, information and services, today announced that ... Simplexa Cytomegalovirus (CMV) molecular test kit on the 3M™ ... Europe. The test is designed to enable hospital labs ...
Cached Biology Technology:The Foremost Expert on Morgellons Disease Highlights the Gravity of This Illness 2Nation's Best Health Care Organizations for Patient Satisfaction, Core Measures Honored by Press Ganey 2Nation's Best Health Care Organizations for Patient Satisfaction, Core Measures Honored by Press Ganey 3Quest Diagnostics CE Marks Simplexa™ Test for Cytomegalovirus for Sale in Europe 2Quest Diagnostics CE Marks Simplexa™ Test for Cytomegalovirus for Sale in Europe 3
Human IL-17D Affinity Purified Polyclonal Ab...
BBS/Glycerol/Casein Block and Diluent - 10X Concentrate, 1 L...
... Immunogen: Synthetic peptide derived from an ... mTOR (Mammalian target of rapamycin FRAP RAFT1 ... mTOR protein. On Western blots it ... Reactivity: Human (positive control: HEK293 cell ...
... to qualitatively detect EGFR ... paraffin-embedded (FFPE) tissue sections, ... cell preparations, using Chromogenic ... Fluorescent In Situ Hybridization ...
Biology Products: