Navigation Links
Bare metal stents deliver gene therapy to heart vessels with less inflammation in animal studies

Improved materials may allow stents, tiny metal scaffolds inserted into blood vessels, to better deliver beneficial genes to patients with heart disease, by reducing the risk of inflammation that often negates initial benefits. The new technique, using a compound that binds in an extremely thin layer to bare metal surfaces, may have potential uses in other areas of medicine that make use of metallic implants.

Cardiologists frequently treat heart disease patients now by using stents to expand partially blocked blood vessels and improve blood flow. However, new obstructions may gradually form within the stents themselves and dangerously narrow the passageway. A newer generation of stents releases drugs to counteract this renarrowing process, called restenosis, but the polymer coatings that initially hold the drugs to the stents may stimulate inflammation. The inflammation in turn leads to restenosis.

Researchers at The Children's Hospital of Philadelphia have developed a novel technique to attach therapeutic genes to a stent's bare metal surface. This technique allows the genes to help heal the surrounding blood vessels, while avoiding the inflammation caused by polymer coatings.

The research team reported their proof-of-principle study, using cell culture and animal models, in the early edition of the Proceedings of the National Academy of Sciences, published online this week.

"This is the first study to demonstrate successful delivery of a gene vector from a bare metal surface," said senior author Robert J. Levy, M.D., the William J. Rashkind Chair of Pediatric Cardiology at The Children's Hospital of Philadelphia. A gene vector is a biological substance, in this case an adenovirus, capable of delivering a therapeutic gene to target cells.

Dr. Levy's team created a unique water-soluble compound, polyallylamine biphosphonate, that binds to the stent's metal alloy surface in a layer with the thickness of only a single molecule.
'"/>

Source:Children's Hospital of Philadelphia


Page: 1 2

Related biology news :

1. Defenseless plants arm themselves with metals
2. Encoded metallic nanowires reveal bioweapons
3. Particle size matters to bacteria ability to immobilize heavy metals
4. New methods of gene delivery using lasers
5. Recombinant DNA technology may enable oral, rather than injectable, delivery of protein drugs
6. Self-assembled DNA buckyballs for drug delivery
7. New research could help us deliver genes for new bone formation
8. Cookbook recipes would cure disease with nontoxic DNA delivery systems
9. Discarded placentas deliver researchers promising cells similar to embryonic stem cells
10. Targeted drug delivery achieved with nanoparticle-aptamer bioconjugates
11. Cellular scale drug delivery from the inside out
Post Your Comments:
(Date:5/22/2013)... is responsible for legionellosis, an infectious disease that can ... pathogen has developed a complex method enabling it to ... avoiding these acting against the infectious bacteria. , Research ... in which teams from the National Institute of Health ... in Barcelona (BSC) have also participated, has described for ...
(Date:5/22/2013)... additives known as phthalates (pronounced THAL-ates) are odorless, ... in flooring, plastic cups, beach balls, plastic wrap, ... Control and Preventionthe bodies of most Americans. Once ... scrutiny. A growing collection of evidence suggests dietary ... and mix with food) may cause significant metabolic ...
(Date:5/21/2013)... shows that the nation,s land and water resources could ... up to 25 billion gallons of algae-based fuel a ... yearly needs. , The findings come from an in-depth ... to grow significant amounts of algae in large, specially ... May 7 issue of Environmental Science and Technology ...
Breaking Biology News(10 mins):Mechanism discovered which aids Legionella to camouflage itself in the organism 2Study links chemicals widely found in plastics and processed food to elevated blood pressure in children and teens 2Going green: Nation equipped to grow serious amounts of pond scum for fuel 2Going green: Nation equipped to grow serious amounts of pond scum for fuel 3Going green: Nation equipped to grow serious amounts of pond scum for fuel 4
... two or more induced abortions have a reduced risk of ... what degree physical activity during pregnancy protects against pre-eclampsia, compared ... from the Norwegian Institute of Public Health (NIPH) that use ... The new results from MoBa were presented on ...
... that plants growing under unfavourable conditions are generally smaller than ... in the US, abiotic stress reduces the yield of agricultural ... the effect of stress in this case, repeated wounding ... which every aspect of their stature, including height, girth, and ...
... A team of researchers led by North Carolina State University ... devices and a host of other revolutionary medical implants. The ... material can be used to create new devices that can ... sensors for diabetics and artificial hemo-dialysis membranes that can scrub ...
Cached Biology News:Previous abortions and exercise: Do they affect pregnancy? 2Previous abortions and exercise: Do they affect pregnancy? 3The bonsai effect: Wounded plants make jasmonates, inhibiting cell division, stunting growth 2NC State finds new nanomaterial could be breakthrough for implantable medical devices 2
(Date:5/22/2013)... AudioNotch is the ... treatment. AudioNotch is pleased to announce a partnership ... in both British Columbia and Alberta, Destination Hearing ... services. AudioNotch's tinnitus treatment program is now available ... Destination Hearing clinic, patients have the detection of ...
(Date:5/22/2013)... PA (PRWEB) May 22, 2013 Envera ... as Fermentation Manager. Mr. McErlean has an extensive ... of leadership positions throughout his career. , ... are very pleased to have Mike join our team”. ... installed large scale fermentation and downstream processing ...
(Date:5/21/2013)... , May 22, 2013 ... drug-only formulation of glycopyrronium bromide designed using Prosonix, particle ... company developing a portfolio of inhaled Respiratory Medicines ... study with PSX1002 that will assess its effect on ... doses in patients with moderate to severe chronic obstructive ...
(Date:5/21/2013)... Through science fairs, workshops, kits for building optical ... organizations will continue their work to increase awareness about ... daily life with the aid of SPIE Education ... countries, are the first of two groups of recipients ... international society for optics and photonics , in 2013. ...
Breaking Biology Technology:AudioNotch Tinnitus Treatment Launches Partnership With Destination Hearing 2Envera Appoints Michael McErlean Fermentation Manager 2Prosonix Initiates Phase 2 Clinical Study with PSX1002 in Patients with Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD) 2Prosonix Initiates Phase 2 Clinical Study with PSX1002 in Patients with Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD) 3Prosonix Initiates Phase 2 Clinical Study with PSX1002 in Patients with Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD) 4Learning About Light: Education Outreach Projects Funded in 10 Countries Through First Round of SPIE Grants 2Learning About Light: Education Outreach Projects Funded in 10 Countries Through First Round of SPIE Grants 3
... film or drop of liquid and the shape of the ... mathematical formula published this week in Physical Review Letters. ... important for a number of areas, including the chemical industry ... to explain how the relationship between the liquid and the ...
... its presence in Europe ... its methodological expertise., BOSTON, April 7, 2008 The ... a Director based in the United,Kingdom. Penny will work closely ... the company,s European and global,business. Penny specializes in the provision ...
... BioSpace, the world,s,leading online bioscience job board and ... Label Career Fair for Regeneron Pharmaceuticals on,Thursday, April ... the Hanover Marriott,in Whippany, New Jersey from 1 ... ), Regeneron is looking to fill ...
Cached Biology Technology:Physicists saved from drowning in complexities of wetting theory 2Observant LLC Appoints Two New Directors to the Senior Management Team 2BioSpace to Host Regeneron Pharmaceuticals Career Fair in Whippany, New Jersey 2
Mouse monoclonal antibody raised against a partial recombinant CENTB2. NCBI Entrez Gene ID = CENTB2...
... tubing prep station, 100-120 V, is used to ... gold particles to create the source of the ... with the Helios gene gun. The station includes ... prep unit, 12 foot Nalgene nitrogen regulator hose, ...
Mouse polyclonal antibody to NR2F2 - nuclear receptor subfamily 2, group F, member 2...
The Discovery Series PDQuest 2-D analysis software is used for imaging, analyzing, and databasing two-dimensional electrophoretic gels. The 10-user network license entitles ten users to access data f...
Biology Products: