Navigation Links
Bare metal stents deliver gene therapy to heart vessels with less inflammation in animal studies

Improved materials may allow stents, tiny metal scaffolds inserted into blood vessels, to better deliver beneficial genes to patients with heart disease, by reducing the risk of inflammation that often negates initial benefits. The new technique, using a compound that binds in an extremely thin layer to bare metal surfaces, may have potential uses in other areas of medicine that make use of metallic implants.

Cardiologists frequently treat heart disease patients now by using stents to expand partially blocked blood vessels and improve blood flow. However, new obstructions may gradually form within the stents themselves and dangerously narrow the passageway. A newer generation of stents releases drugs to counteract this renarrowing process, called restenosis, but the polymer coatings that initially hold the drugs to the stents may stimulate inflammation. The inflammation in turn leads to restenosis.

Researchers at The Children's Hospital of Philadelphia have developed a novel technique to attach therapeutic genes to a stent's bare metal surface. This technique allows the genes to help heal the surrounding blood vessels, while avoiding the inflammation caused by polymer coatings.

The research team reported their proof-of-principle study, using cell culture and animal models, in the early edition of the Proceedings of the National Academy of Sciences, published online this week.

"This is the first study to demonstrate successful delivery of a gene vector from a bare metal surface," said senior author Robert J. Levy, M.D., the William J. Rashkind Chair of Pediatric Cardiology at The Children's Hospital of Philadelphia. A gene vector is a biological substance, in this case an adenovirus, capable of delivering a therapeutic gene to target cells.

Dr. Levy's team created a unique water-soluble compound, polyallylamine biphosphonate, that binds to the stent's metal alloy surface in a layer with the thickness of only a single molecule.
'"/>

Source:Children's Hospital of Philadelphia


Page: 1 2

Related biology news :

1. Defenseless plants arm themselves with metals
2. Encoded metallic nanowires reveal bioweapons
3. Particle size matters to bacteria ability to immobilize heavy metals
4. New methods of gene delivery using lasers
5. Recombinant DNA technology may enable oral, rather than injectable, delivery of protein drugs
6. Self-assembled DNA buckyballs for drug delivery
7. New research could help us deliver genes for new bone formation
8. Cookbook recipes would cure disease with nontoxic DNA delivery systems
9. Discarded placentas deliver researchers promising cells similar to embryonic stem cells
10. Targeted drug delivery achieved with nanoparticle-aptamer bioconjugates
11. Cellular scale drug delivery from the inside out
Post Your Comments:
(Date:7/10/2014)... NEW YORK , June 27, 2014 /PRNewswire/ ... against Provectus Biopharmaceuticals, Inc. ("Provectus" or the "Company")(NYSE-MKT: ... action, filed in United States District Court, Middle ... Division, is on behalf of a class consisting ... otherwise acquired Provectus securities between December 17, 2013 ...
(Date:7/10/2014)... -- NXT-ID, Inc., (OTCQB: NXTD) a biometric authentication company focused on the ... was interviewed on July 1 st on the ... . Mr. Pereira discusses the company,s next generation smart wallet ... the Wocket™ aims to replace a traditional wallet with a ... tells Gino he has never heard of the Wocket ...
(Date:7/10/2014)... GOTHENBURG, Sweden , July 8, 2014 ... FPC1021 has won a new design win (DW). An Asian ... targeted date for mass production start in August 2014.   ... an Asian smartphone OEM, which has a planned date for ... received an initial ramp order of SEK 5M, for delivery ...
Breaking Biology News(10 mins):SHAREHOLDER ALERT: Pomerantz Law Firm Announces the Filing of a Class Action against Provectus Biopharmaceuticals, Inc. and Certain Officers - PVCT 2SHAREHOLDER ALERT: Pomerantz Law Firm Announces the Filing of a Class Action against Provectus Biopharmaceuticals, Inc. and Certain Officers - PVCT 3Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 2Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 3Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 4FPC Wins DW and Initial Ramp Order for FPC1021 Touch Sensor for Flagship Smartphone from Asian OEM 2
... biology textbooks, a single genetic mutation is rarely enough to ... a series of mutations that work together to trigger tumor ... that distinct cancer-causing mutations in neighboring cells can cooperate to ... Cancer biologists have long known that it takes ...
... , CARDIFF, Calif. , Jan. 13 ... Mind, Inc. was in high demand at this year,s Consumer Electronics Show ... many interviews with major media organizations during the 3 day event. Among ... Up TV , with Mark Albertson . Additionally, we have been ...
... Cold Spring Harbor, N.Y. Two scientists from ... international team that has discovered a genetic mutation that ... is a devastating inherited neurological disease that is very ... often among Ashkenazi Jews. The study was ...
Cached Biology News:Mutations in different cells cooperate to set the stage for cancer 2Mutations in different cells cooperate to set the stage for cancer 3Jedi Mind Receives Vast Media Coverage at CES in Las Vegas 2Jedi Mind Receives Vast Media Coverage at CES in Las Vegas 3CSHL scientists use next-gen sequencing to rapidly discover genetic cause of devastating disorder 2
(Date:7/10/2014)... researchers at the University of Illinois at Urbana-Champaign ... the interplay of spin and heat at the ... spintronic devices for data storage and information processing. ... as spin-angular momentum. In a typical charge current, ... spin current," explained David Cahill, a professor of ...
(Date:1/15/2014)... approach akin to assembling a club sandwich at ... (NIST) researchers have succeeded in crafting a uniform, ... of foam commonly used in upholstered furniture and ... nanotube-coated polyurethane foam was reduced 35 percent compared ...
(Date:1/15/2014)... JOLIET, Ill. , Jan. 15, 2014  Bill Jacobs Automotive, ... , is teaming up with the Heartland Blood Center ... annual blood drive. The drive takes place Saturday, Jan. 18 ... a.m. - 2 p.m. (Photo: http://photos.prnewswire.com/prnh/20140115/MN46637 )  ...
(Date:1/15/2014)... FALLS, N.Y., Jan. 15, 2014   Niagara Thermal ... been selected by Buffalo BioBlower Technologies LLC ("B3") as ... SBIR Phase 2 award from the Army Corps of ... system that kills all biological contaminants and destroys VOCs ...
Breaking Biology Technology:University of Illinois study advances limits for ultrafast nano-devices 2Layered security: Carbon nanotubes promise improved flame-resistant coating 2Join the Bill Jacobs Auto blood drive and receive a free oil change 2Niagara Thermal Products LLC Selected as Critical Supplier for Buffalo BioBlower Air Purification Systems 2
... can make a professor lose his cool more than having ... for making a mistake are endless: a DVD made specifically ... skipping around uncontrollably or even an overhead projector falling to ... duty of solving such technical issues and more falls on ...
... Madison, Wis. - If wireless keeps growing at its ... get their work done, says a wireless channel manager for ... at a recent Accelerate Madison program, saying the ... for corporations over the next few years. With costs falling ...
... Eau Claire, Wis . Faculty in the chemistry ... more than $600,000 in grant money from the National ... help them purchase state-of-the-art instrumentation and support faculty-student research. ... a department like ours and it'll have a significant ...
Cached Biology Technology:Interest drives investment of instructional technology 2Interest drives investment of instructional technology 3Interest drives investment of instructional technology 4Cisco manager touts wireless advantages 2UW-Eau Claire chemistry faculty get $600,000 in NSF grants 2UW-Eau Claire chemistry faculty get $600,000 in NSF grants 3
... Activated affinity media for spontaneous ligand immobilization can ... antibody, enzyme, antigen, or receptor to create an ... 15 supports couple ligands via primary amines. Affi-Gel ... pI from 6.5 to 11; Affi-Gel 15 gel ...
pH-dependent fluorescence; Maximum intensity observed in basic solutions....
Anti-Chicken IgY, (IgG) F(ab')2 Fragment Specific....
Presenilin 2 Immunogen: Synthetic peptide corresponding to residues 31-47 of human Presenilin 2. Storage: -20 C, Avoid Freeze/Thaw Cycles...
Biology Products: