Navigation Links
Bacterial walls come tumbling down

The first detailed images of an elusive drug target on the outer wall of bacteria may provide scientists with enough new information to aid design of novel antibiotics. The drugs are much needed to treat deadly infections initiated by Staphylococcus aureus and other bacterial pathogens.

The research team, led by Natalie Strynadka, a Howard Hughes Medical Institute (HHMI) international research scholar at the University of British Columbia in Vancouver, Canada, published its findings in the March 9, 2007, issue of the journal Science.

Penicillin and many newer antibiotics work by blocking a piece of the machinery bacteria use to construct their durable outer walls. Without these tough, protective coatings, bacteria die. The enzymatic machinery (known as PBP2) studied by Strynadka's group has two main parts: One end assembles long sugar fibers; the other end stitches them together with bits of protein to form a sturdy interlocking mesh shell.

Strynadka's team has provided a long-awaited look at the portion of the enzyme used in the first step of the biochemical pathway that initiates assembly of the sugar coating. The second step is targeted by penicillin and has been well studied.

Although scientists have spent many years identifying bacterial components whose structural features might have weaknesses that can be exploited by antibiotics, progress in turning up bona fide drug targets has been slow. The cell wall enzymes in particular have tantalized scientists, Strynadka said. "The cell wall has all the hallmarks of a great drug target," she explained. "It is essential to the survival of all bacteria. The enzymes that create the cell wall are unique to bacteria. And it is accessible; you don't have to get the antibiotics into the cell."

In their structural studies, the researchers focused on Staphylococcus aureus, a notorious human pathogen. An epidemic strain of the bacteria known as methicillin-resistant Staphylococc
'"/>

Source:Howard Hughes Medical Institute


Page: 1 2 3

Related biology news :

1. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
2. Bacterial genome sheds light on synthesizing cancer-fighting compounds
3. New insight into autoimmune disease: Bacterial infections promote recognition of self-glycolipids
4. Say what? Bacterial conversation stoppers
5. Bacterial protein mimics host to cripple defenses
6. Bacterial switch gene regulates how oceans emit sulfur into atmosphere
7. Bacterial protein shows promise in treating intestinal parasites
8. Bacterial response to oxidation studied as toxin barometer
9. Newly discovered protein kills anthrax bacteria by exploding their cell walls
10. No cell walls, no new cancer cells
11. Learning to fight an adversary that wont stay down
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Bacterial walls come tumbling down

(Date:8/22/2014)... available in German . ... PCFs proteins are fixated in a way so as ... the HZB and Fudan University researchers are planning on ... materials. Their findings are being published today in the ... Proteins are sensitive molecules. Everyone knows that at ...
(Date:8/22/2014)... a multifunctional enzyme that localizes to ... and cholesterol-synthesizing activities. DHCR24 overexpression confers ... β deposition. Dr. Xiuli Lu and ... constructed two recombinant adenoviruses (Ad-rSYN1-DHCR24-myc and ... in neuronal cells. They also found ...
(Date:8/21/2014)... team of scientists including researchers from the University of Georgia ... as canolain the journal Science . Their discovery paves ... used widely in farming and industry. , Canola is ... the winter crop is increasingly cultivated in Georgia. Canola oil ... of saturated fat and rich supply of omega-3 fatty acids, ...
Breaking Biology News(10 mins):Proteins: New class of materials discovered 2Canola genome sequence reveals evolutionary 'love triangle' 2
... "world summit" will bring together internationally renowned scientists from 12 ... India to address ancient microscopic fossils, from July 27 ... together the world,s best scientists in the field of ancient ... of the UCLA Institute of Geophysics and Planetary Physics, Center ...
... A University of Washington study of top-selling laundry products ... different chemicals. All six products tested gave off at ... federal laws, but none of those chemicals was listed ... in this topic because people were telling me that ...
... month remaining before the Beijing Olympics, Chinese officials have introduced ... Games. A new tool has been installed in the capital ... these efforts. Poor air quality could pose problems for ... outdoors in endurance sports, such as cycling and marathons. ...
Cached Biology News:UCLA 'world summit' to explore ancient life on Earth, and beyond 2Toxic chemicals found in common scented laundry products, air fresheners 2Toxic chemicals found in common scented laundry products, air fresheners 3Air quality forecasts for China 2
(Date:8/21/2014)... Aug. 21, 2014  Decision Resources Group finds ... and Mexico ... several newly approved agents, the anticipated label extension ... the launch of emerging biologics will substantially increase ... the emerging IL-5 inhibitors will introduce a new dynamic ...
(Date:8/21/2014)... KONG , Aug. 21, 2014  China Cord Blood ... announced its plan to release financial results for the ... 28, 2014, after market close in the US.  ... at 8:00 a.m. ET on Friday, August 29, 2014 ... overview of the Company,s recent developments, followed by a ...
(Date:8/21/2014)... Ontotext S4 , The Self Service ... Now the same enterprise hardened text mining, Linked ... data is available to start-ups and mid-size businesses at ... that do not have resources to evaluate and prototype ... since there is no need for on premise hardware ...
(Date:8/21/2014)... August 21, 2014 On Wednesday of last ... to use Redox Signaling molecules, became available for purchase in ... , "The way that RENU 28 works is, if you ... down of the rate of cellular renewal within your body. ... increasing of that rate of cellular renewal. What RENU 28 ...
Breaking Biology Technology:Asthma Agents Currently Face a Suboptimal Coverage Environment in Brazil and Mexico, and as the Treatment Armamentarium Expands, Competitiveness Will Further Intensify 2Asthma Agents Currently Face a Suboptimal Coverage Environment in Brazil and Mexico, and as the Treatment Armamentarium Expands, Competitiveness Will Further Intensify 3China Cord Blood Corporation to Report First Quarter of Fiscal 2015 Financial Results 2Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 2Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 3Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 4RENU 28 Skin Care Now Available in Australia and New Zealand 2
... up most of the tab for damage caused by invasive ... other goods imported from countries into the United States every ... financial damage of importing foreign insects into the nation and ... the journal PLoS One today. ,The ...
... Mass High Tech has selected Greenberg Traurig ... its 2011 All-Stars Award, one that recognizes 15 driven ... Camacho will be recognized for her wide ... sciences sector.  As a patent attorney, she represents pharmaceutical ...
... 9, 2011 PharmaVentures Limited, experts ... that they have been engaged by leading drug ... for an established full service CMC (chemistry, manufacturing ... The engagement will utilise PharmaVentures, asset divestment expertise ...
Cached Biology Technology:Homeowners, taxpayers pay billions to fight invasive pests 2Homeowners, taxpayers pay billions to fight invasive pests 3Greenberg Traurig Shareholder Jennifer A. Camacho Selected to Receive Mass High Tech's 2011 All-Stars Award 2