Navigation Links
Bacterial protein mimics host to cripple defenses

Like a wolf in sheep's clothing, a protein from a disease-causing bacterium slips into plant cells and imitates a key host protein in order to cripple the plant's defenses. This discovery, reported in this week's Science Express by researchers at the Boyce Thompson Institute (BTI) for Plant Research, advances the understanding of a disease mechanism common to plants, animals, and people.

That mechanism, called programmed cell death (PCD), causes a cell to commit suicide. PCD helps organisms contain infections, nip potential cancers in the bud, and get rid of old or unneeded cells. However, runaway PCD leads to everything from unseemly spots on tomatoes to Parkinson's and Alzheimer's diseases.

BTI Scientist and Cornell University Professor of Plant Pathology Gregory Martin studies the interaction of Pseudomonas syringae bacteria with plants to find what determines whether a host succumbs to disease. Martin and graduate student Robert Abramovitch previously found that AvrPtoB, a protein Pseudomonas injects into plants, disables PCD in a variety of susceptible plants and in yeast (a single-celled ancestor of both plants and animals). Abramovitch and Martin compared AvrPtoB's amino acid sequence to known proteins in other microbes and in higher organisms, but found no matches that might hint at how the protein works at the molecular level.

"We had some biochemical clues to what AvrPtoB was doing, but getting the three-dimensional crystal structure was really key," Martin explained. To find that structure, Martin and Abramovitch worked with collaborators at Rockefeller University. The structure of AvrPtoB revealed that the protein looks very much like a ubiquitin ligase, an enzyme plant and animal cells use to attach the small protein ubiquitin to unneeded or defective proteins. Other enzymes then chew up and "recycle" the ubiquitin-tagged proteins.

To confirm that AvrPtoB was a molecular mimic, Martin and Abramovitch altered parts of the
'"/>

Source:Boyce Thompson Institute for Plant Research


Page: 1 2

Related biology news :

1. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
2. Bacterial genome sheds light on synthesizing cancer-fighting compounds
3. New insight into autoimmune disease: Bacterial infections promote recognition of self-glycolipids
4. Say what? Bacterial conversation stoppers
5. Bacterial switch gene regulates how oceans emit sulfur into atmosphere
6. Bacterial protein shows promise in treating intestinal parasites
7. Bacterial response to oxidation studied as toxin barometer
8. Bacterial walls come tumbling down
9. New, automated tool successfully classifies and relates proteins in unprecedented way
10. New binding target for oncogenic viral protein
11. Controversial drug shown to act on brain protein to cut alcohol use
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Bacterial protein mimics host cripple defenses

(Date:5/21/2015)... BOSTON , May 21, 2015 ... scientific potential of music for health, today announced a ... (BerkleeICE) . The partnership will center on collaboration on ...  As a first step in the collaboration, The Sync ... course on "Music as Medicine" in the 2015-2016 academic ...
(Date:5/20/2015)... 2015 NXT-ID, Inc. (NASDAQ: NXTD ) ... subsidiary, 3D-ID LLC, a company engaged in biometric identification ... biometrics technology portion of the recently awarded TIES (Technical ... of the Army. 3D-ID LLC has a ... law enforcement and security agencies. Gino ...
(Date:5/19/2015)... 19, 2015  Technology is rapidly advancing, outpacing enterprises, ... the cloud. Passwords and their management are soon to ... standards-based specifications such as those developed by the FIDO ... passwords presents for BYOD, COPE, IoT, and mobile payments, ... protocol. In response to the call ...
Breaking Biology News(10 mins):The Sync Project Announces Partnership with Berklee College of Music's Institute for Creative Entrepreneurship 2The Sync Project Announces Partnership with Berklee College of Music's Institute for Creative Entrepreneurship 3NXT-ID, Inc Announces Participation as Member of Team Battelle for TIES Contract Award 2NXT-ID, Inc Announces Participation as Member of Team Battelle for TIES Contract Award 3HYPR Corp. Biometric Security Integration Kit Shields Applications and Devices Across the Internet of Things 2HYPR Corp. Biometric Security Integration Kit Shields Applications and Devices Across the Internet of Things 3
... powerful class of antioxidants could one day be a potent ... antioxidants called synthetic triterpenoids blocked development of Parkinson,s in an ... days, said Dr. Bobby Thomas, neuroscientist at the Medical College ... of the study in the journal Antioxidants & Redox ...
... Award for Innovative Excellence, the Society,s highest award. ... Fulwyler, the inventor of the electrostatic cell sorter, and ... Dr. Terstappen received his Ph.D. in Applied Physics from ... pioneering cytometry research at Becton Dickinson. In 1994, ...
... July 23, 2012 Scientists at Joslin Diabetes ... (GLP-1), a gut hormone, protects against kidney disease, and ... findings, which are reported today online by Diabetes, may ... harness the actions of GLP-1 to prevent the harmful ...
Cached Biology News:Powerful class of antioxidants may be potent Parkinson's treatment 2The International Society for Advancement of Cytometry presented its 2012 awards at CYTO 2012 2The International Society for Advancement of Cytometry presented its 2012 awards at CYTO 2012 3Joslin researchers gain new understanding of diabetes and kidney disease 2Joslin researchers gain new understanding of diabetes and kidney disease 3
(Date:6/2/2015)... 2, 2015   Intrexon Corporation (NYSE: ... announced today the appointment of Olivier R. ... Sector.  Mr. Jarry will lead the expansion of ... applications for consumer markets.  Mr. ... experience in leading global life sciences and consumer ...
(Date:6/2/2015)... GOJO, inventors of PURELL ® Advanced ... at the White House Forum.  GOJO was among 150 ... stakeholders at the White House Forum to announce commitments ... of antibiotic-resistant bacteria, detect resistant strains, preserve the efficacy ... resistant infections. "A primary prevention approach to ...
(Date:6/1/2015)... NY (PRWEB) June 02, 2015 ... on health care, Jack Uldrich has been selected ... in New York today. He will deliver his ... , Uldrich has delivered presentations to the American ... of Audiology and Neurology, Alcetel-Lucent/Verizon Forum on Wireless ...
(Date:6/1/2015)... 1, 2015 GenomeDx Biosciences today ... platform, successfully classified various subtypes of bladder ... certain biomarkers, including one type associated with ... genomic signature has potential as a tool ... in patients with muscle-invasive bladder cancers (MIBC). ...
Breaking Biology Technology:Intrexon Announces New Sector Leader 2Intrexon Announces New Sector Leader 3GOJO Among Leaders At The White House Forum On Antibiotic Stewardship 2GOJO Among Leaders At The White House Forum On Antibiotic Stewardship 3GOJO Among Leaders At The White House Forum On Antibiotic Stewardship 4Futurist Jack Uldrich to Address the Future of Pharmaceuticals 2GenomeDx's Decipher Platform Validates Genomic Signature that may Predict Resistance to Chemotherapy in Bladder Cancer Patients in Study Presented at ASCO 2015 Annual Meeting 2GenomeDx's Decipher Platform Validates Genomic Signature that may Predict Resistance to Chemotherapy in Bladder Cancer Patients in Study Presented at ASCO 2015 Annual Meeting 3GenomeDx's Decipher Platform Validates Genomic Signature that may Predict Resistance to Chemotherapy in Bladder Cancer Patients in Study Presented at ASCO 2015 Annual Meeting 4
... , Parallel Phase 2 studies could expedite development ... Oct. 16 /PRNewswire-FirstCall/ - Resverlogix Corp. ("Resverlogix" or ... the Company,s Annual General Meeting for shareholders highlighting ... drug, RVX-208, for the treatment of cardiovascular disease. ...
... Based on its annual assessment of companies making ... Agile Therapeutics, Inc. (Agile) with the 2009 North ... Year Award for its outstanding achievements in drug ... great potential as a convenient contraceptive option. Not ...
... , - New Neuroscience Research ... and Used by the National Institutes of,Health, Will be Showcased ... Elsevier, the leading publisher of scientific, technical and ... new,features it is rolling out for its BrainNavigator research tool ...
Cached Biology Technology:Resverlogix Updates Shareholders on Accelerated Clinical Trial Plan 2Resverlogix Updates Shareholders on Accelerated Clinical Trial Plan 3Resverlogix Updates Shareholders on Accelerated Clinical Trial Plan 4Frost & Sullivan Recognizes Agile Therapeutics for Its Innovative Weekly Low-Dose Contraceptive Patch 2Frost & Sullivan Recognizes Agile Therapeutics for Its Innovative Weekly Low-Dose Contraceptive Patch 3Frost & Sullivan Recognizes Agile Therapeutics for Its Innovative Weekly Low-Dose Contraceptive Patch 4Frost & Sullivan Recognizes Agile Therapeutics for Its Innovative Weekly Low-Dose Contraceptive Patch 5Elsevier's BrainNavigator Research Tool to Launch new Features at Neuroscience 2009 Show 2Elsevier's BrainNavigator Research Tool to Launch new Features at Neuroscience 2009 Show 3Elsevier's BrainNavigator Research Tool to Launch new Features at Neuroscience 2009 Show 4Elsevier's BrainNavigator Research Tool to Launch new Features at Neuroscience 2009 Show 5
... (IC50 = 59.2 M). Formula: ... O 13 MolWeight: ... RT CAS: ... to 100 mM in DMSO IUPAC: ...
POU domain, class 2, transcription factor 2,...
NAP-2 (5C7)...
IKKbeta/IKK-2 Polyclonal Antibody 100 ug affinity purified rabbit polyclonal antibody. Reacts with human. Tested in Western blotting....
Biology Products: