Navigation Links
Bacterial genome sheds light on synthesizing cancer-fighting compounds

Sea squirts around the world are breathing a sigh of relief, as they no longer run the risk of being harvested for their natural disease-fighting substances. Scientists recently discovered that the bacterium Prochloron didemnii, which lives symbiotically inside the sea squirt, actually produces the desired patellamides, compounds that may one day be used in cancer treatment.

Despite decades of attempts, scientists could not successfully cultivate Prochloron in the laboratory once the bacterium was isolated from the sea squirt. Because samples of Prochloron were easily contaminated with remnants of life inside its animal home, scientists couldn't tell if the bacterium or the sea squirt produced the sought-after patellamides, until now.

By searching for patellamide synthesis instructions in genomic sequences, scientists found the bacterium indeed has the necessary genes to produce these potentially important biochemicals, solving the source mystery. Knowing which genes Prochloron used for patellamide production also allowed researchers to synthesize the potentially important compounds in the lab using a so-called laboratory workhorse, the bacterium E. coli.

Scientists from The Institute for Genomic Research (TIGR), the University of Utah and the University of California, San Diego, report findings in this week's online edition of the Proceedings of the National Academy of Sciences.

"This project revealed detailed information about the metabolic capabilities of Prochloron, details that proved to be difficult to determine by other means, " said Patrick Dennis, manager for Prochloron genome sequencing at the National Science Foundation, which funded the study. "Furthermore, " he added, "by producing patellamides in the lab, the team demonstrated an important proof of principle for the biosynthesis of naturally occurring marine products."


'"/>

Source:National Science Foundation


Page: 1

Related biology news :

1. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
2. New insight into autoimmune disease: Bacterial infections promote recognition of self-glycolipids
3. Say what? Bacterial conversation stoppers
4. Bacterial protein mimics host to cripple defenses
5. Bacterial switch gene regulates how oceans emit sulfur into atmosphere
6. Bacterial protein shows promise in treating intestinal parasites
7. Bacterial response to oxidation studied as toxin barometer
8. Bacterial walls come tumbling down
9. Man and mouse share genome structures
10. Whole genome fine map of rice completed
11. Study finds more than one-third of human genome regulated by RNA
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/20/2017)... 2017 Delta (NYSE: DAL ) customers now can ... at Reagan Washington National Airport (DCA). ... Delta launches biometrics to board aircraft at Reagan ... Delta,s biometric boarding pass experience that ... now integrated into the boarding process to allow eligible Delta SkyMiles Members ...
(Date:6/23/2017)... and ITHACA, N.Y. , June 23, ... University, a leader in dairy research, today announced a ... to help reduce the chances that the global milk ... of this dairy project, Cornell University has become the ... the Food Supply Chain, a food safety initiative that ...
(Date:5/23/2017)... , May 23, 2017  Hunova, the first robotic gym for the ... been officially launched in Genoa, Italy . The first ... and the USA . The technology was developed ... market by the IIT spin-off Movendo Technology thanks to a 10 million ... News Release, please click: ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... 2017 , ... ComplianceOnline’s Medical Device Summit is back for its 4th year. ... San Francisco, CA. The Summit brings together current and former FDA office bearers, regulators, ... government officials from around the world to address key issues in device compliance, quality ...
(Date:10/11/2017)... ... 11, 2017 , ... A new study published in Fertility ... fresh in vitro fertilization (IVF) transfer cycles. The multi-center matched cohort ... After comparing the results from the fresh and frozen transfer cohorts, the authors ...
(Date:10/10/2017)... California (PRWEB) , ... October 10, 2017 , ... Dr. ... speaking at his local San Diego Rotary Club. The event entitled ... Diego, CA and had 300+ attendees. Dr. Harman, DVM, MPVM was joined by ...
(Date:10/9/2017)... Oct. 9, 2017  BioTech Holdings announced today ... which its ProCell stem cell therapy prevents limb ... The Company, demonstrated that treatment with ProCell resulted ... saved as compared to standard bone marrow stem ... resulted in reduction of therapeutic effect.  ...
Breaking Biology Technology: