Navigation Links
Bacterial genome sheds light on synthesizing cancer-fighting compounds

Sea squirts around the world are breathing a sigh of relief, as they no longer run the risk of being harvested for their natural disease-fighting substances. Scientists recently discovered that the bacterium Prochloron didemnii, which lives symbiotically inside the sea squirt, actually produces the desired patellamides, compounds that may one day be used in cancer treatment.

Despite decades of attempts, scientists could not successfully cultivate Prochloron in the laboratory once the bacterium was isolated from the sea squirt. Because samples of Prochloron were easily contaminated with remnants of life inside its animal home, scientists couldn't tell if the bacterium or the sea squirt produced the sought-after patellamides, until now.

By searching for patellamide synthesis instructions in genomic sequences, scientists found the bacterium indeed has the necessary genes to produce these potentially important biochemicals, solving the source mystery. Knowing which genes Prochloron used for patellamide production also allowed researchers to synthesize the potentially important compounds in the lab using a so-called laboratory workhorse, the bacterium E. coli.

Scientists from The Institute for Genomic Research (TIGR), the University of Utah and the University of California, San Diego, report findings in this week's online edition of the Proceedings of the National Academy of Sciences.

"This project revealed detailed information about the metabolic capabilities of Prochloron, details that proved to be difficult to determine by other means, " said Patrick Dennis, manager for Prochloron genome sequencing at the National Science Foundation, which funded the study. "Furthermore, " he added, "by producing patellamides in the lab, the team demonstrated an important proof of principle for the biosynthesis of naturally occurring marine products."


'"/>

Source:National Science Foundation


Page: 1

Related biology news :

1. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
2. New insight into autoimmune disease: Bacterial infections promote recognition of self-glycolipids
3. Say what? Bacterial conversation stoppers
4. Bacterial protein mimics host to cripple defenses
5. Bacterial switch gene regulates how oceans emit sulfur into atmosphere
6. Bacterial protein shows promise in treating intestinal parasites
7. Bacterial response to oxidation studied as toxin barometer
8. Bacterial walls come tumbling down
9. Man and mouse share genome structures
10. Whole genome fine map of rice completed
11. Study finds more than one-third of human genome regulated by RNA
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/5/2018)... BOSTON (PRWEB) , ... October 04, 2018 , ... ... cloud-based enterprise-class unified communications and collaboration solutions, was present at Microsoft Ignite 2018, ... Office 365 communication solutions. , Microsoft issued a statement about the new direction ...
(Date:10/5/2018)... ... October 04, 2018 , ... Nothing brings a team together ... so popular. , Cooking appeals to companies because it encourages a range ... cohesion, collaboration and decision-making skills. It’s also appealing in that everyone – no ...
(Date:10/2/2018)... ... 2018 , ... Stuart is a fun-loving eight-year-old Labrador retriever. Like many labs, Stuart’s favorite ... loves playing ball so much that whenever anyone comes to our door, he grabs a ... fetch.” In early 2017, Stuart began limping and eventually could no longer play fetch. ...
Breaking Biology News(10 mins):
(Date:9/28/2018)... ... September 28, 2018 , ... GlycoMark®, Inc. ... availability of the GlycoMark test, the only FDA-cleared blood test specific to detecting ... will promote and offer the GlycoMark test to its network of physicians through ...
(Date:9/27/2018)... N.J. (PRWEB) , ... September 26, 2018 , ... ... DNA testing are way ahead of their primary care physicians, according to a ... For this study, patients and doctors were asked about consumer adoption of fitness ...
(Date:9/27/2018)... ... September 27, 2018 , ... This past weekend at ... Mobile Technology, Inc. announced they will formally merge companies and integrate their technologies ... (TB) and other diseases. These two social enterprise corporations, both of which focus ...
(Date:9/22/2018)... ... September 20, 2018 , ... ... venture. The synergistic combination of Predicine’s GeneRADAR molecular insights platform with Flagship’s ... to empower clinical trials in the immuno-oncology (IO) space. , IO therapies ...
Breaking Biology Technology: