Navigation Links
Bacterial genome sheds light on synthesizing cancer-fighting compounds

Sea squirts around the world are breathing a sigh of relief, as they no longer run the risk of being harvested for their natural disease-fighting substances. Scientists recently discovered that the bacterium Prochloron didemnii, which lives symbiotically inside the sea squirt, actually produces the desired patellamides, compounds that may one day be used in cancer treatment.

Despite decades of attempts, scientists could not successfully cultivate Prochloron in the laboratory once the bacterium was isolated from the sea squirt. Because samples of Prochloron were easily contaminated with remnants of life inside its animal home, scientists couldn't tell if the bacterium or the sea squirt produced the sought-after patellamides, until now.

By searching for patellamide synthesis instructions in genomic sequences, scientists found the bacterium indeed has the necessary genes to produce these potentially important biochemicals, solving the source mystery. Knowing which genes Prochloron used for patellamide production also allowed researchers to synthesize the potentially important compounds in the lab using a so-called laboratory workhorse, the bacterium E. coli.

Scientists from The Institute for Genomic Research (TIGR), the University of Utah and the University of California, San Diego, report findings in this week's online edition of the Proceedings of the National Academy of Sciences.

"This project revealed detailed information about the metabolic capabilities of Prochloron, details that proved to be difficult to determine by other means, " said Patrick Dennis, manager for Prochloron genome sequencing at the National Science Foundation, which funded the study. "Furthermore, " he added, "by producing patellamides in the lab, the team demonstrated an important proof of principle for the biosynthesis of naturally occurring marine products."


Source:National Science Foundation

Page: 1

Related biology news :

1. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
2. New insight into autoimmune disease: Bacterial infections promote recognition of self-glycolipids
3. Say what? Bacterial conversation stoppers
4. Bacterial protein mimics host to cripple defenses
5. Bacterial switch gene regulates how oceans emit sulfur into atmosphere
6. Bacterial protein shows promise in treating intestinal parasites
7. Bacterial response to oxidation studied as toxin barometer
8. Bacterial walls come tumbling down
9. Man and mouse share genome structures
10. Whole genome fine map of rice completed
11. Study finds more than one-third of human genome regulated by RNA
Post Your Comments:

(Date:6/1/2016)... , June 1, 2016 ... in Election Administration and Criminal Identification to Boost Global ... a recently released TechSci Research report, " Global Biometrics ... Region, Competition Forecast and Opportunities, 2011 - 2021", the ... billion by 2021, on account of growing security concerns ...
(Date:5/16/2016)... NEW YORK , May 16, 2016   ... authentication solutions, today announced the opening of an IoT ... to strengthen and expand the development of embedded ... provides an unprecedented level of convenience and security with ... to authenticate one,s identity aside from DNA. EyeLock,s platform ...
(Date:5/3/2016)... , May 3, 2016  Neurotechnology, a ... the MegaMatcher Automated Biometric Identification System (ABIS) ... large-scale multi-biometric projects. MegaMatcher ABIS can process multiple ... using any combination of fingerprint, face or iris ... MegaMatcher SDK and MegaMatcher Accelerator , ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... , June 27, 2016  Liquid Biotech ... announced the funding of a Sponsored Research Agreement ... circulating tumor cells (CTCs) from cancer patients.  The ... in CTC levels correlate with clinical outcomes in ... These data will then be employed to support ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... While the ... such as the Cary 5000 and the 6000i models are higher end machines that ... the height of the spectrophotometer’s light beam from the bottom of the cuvette holder. ...
(Date:6/23/2016)... June 23, 2016   Boston Biomedical , ... compounds designed to target cancer stemness pathways, announced ... granted Orphan Drug Designation from the U.S. Food ... gastric cancer, including gastroesophageal junction (GEJ) cancer. Napabucasin ... to inhibit cancer stemness pathways by targeting STAT3, ...
(Date:6/23/2016)... , ... June 23, 2016 , ... ... YM (Yeast and Mold) microbial test has received AOAC Research Institute approval 061601. ... microbial tests introduced last year,” stated Bob Salter, Vice President of Regulatory and ...
Breaking Biology Technology: