Navigation Links
Bacteria that cause tooth decay able to survive without important biochemical pathway

suffer from tooth decay. Considered by the U.S. surgeon general to be a "silent epidemic," tooth decay is a chronic childhood disease that affects five times more children than asthma and is estimated to result in 51 million lost school hours.

In an effort to understand how best to combat the tooth-decaying properties of S. mutans, Brady and her team set out to learn how the organism was able to survive its own acid. To find out, the researchers tinkered with systematically turning off several genes, individually and in combination, to see how the bacteria responded.

"We found S. mutans can survive, with normal growth, without the SRP pathway," said Adnan Hasona, Ph.D., a research assistant professor of oral biology and the study's lead author.

The bacteria altered to lack SRP components were able to adapt and survive gradual increases in acid resulting from their own metabolism, suggesting a backup pathway was in place.

But, like goldfish dropped in new water, the altered bacteria could not contend with sudden environmental change. When artificially shocked with acid to a pH below that where tooth demineralization begins, the altered bacteria became sick and unable to grow. Shocking the bacteria with other environmental stressors, such as high salt levels or the presence of hydrogen peroxide, also caused them to weaken, Hasona said.

"So, at least in this organism, we learned the SRP pathway seems to enable it to respond rapidly to environmental stress, but it was not at all necessary for the organism's viability during non-stress conditions," Brady said.

Brady's team surmised that two other molecules, called YidC1 and YidC2, might be acting as alternate routes for protein delivery in the absence of the SRP pathway. They tested their hypothesis and found that S. mutans could continue to function in non-stress conditions without the SRP and YidC1 genes, but not without the YidC2 and SRP simultaneously.

"The fa
'"/>

Source:University of Florida


Page: 1 2 3

Related biology news :

1. Bacteria collection sheds light on urinary tract infections
2. Solution to Pollution: New Bacteria Eats Toxic Waste
3. The Bacterias guide to survival
4. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
5. Bacterial genome sheds light on synthesizing cancer-fighting compounds
6. Where Bacteria Get Their Genes
7. Bacteria feed on smelly breath (and feet)
8. New insight into autoimmune disease: Bacterial infections promote recognition of self-glycolipids
9. Bacteria use hosts immune response to their competitive advantage
10. Say what? Bacterial conversation stoppers
11. Bacteria are key to green plastics, drugs
Post Your Comments:
(Date:12/11/2014)... PAUL, Minn. , Dec. 10, 2014 /PRNewswire/ ... wireless physiologic monitoring, has released a new series ... needs of preclinical toxicology researchers. M series, part ... help toxicologists collect the best possible physiologic data ... Adding functional endpoints to toxicology studies ...
(Date:12/10/2014)...  Wake Forest Baptist Medical Center today announced plans for ... Medicine. Funding for this $50 million capital project is ... publicly launched next summer. The medical ... series R.J. Reynolds Tobacco Company complex, adjacent to 525@vine ... with plans to be ready to welcome medical students ...
(Date:12/10/2014)... , December 9, 2014 ... ITN,s BCARD Platform   ... enterprise meeting scheduling solutions for business-to-business (B2B) events, ... world leader in mobile near-field communication (NFC), Bluetooth ...      (Logo: http://photos.prnewswire.com/prnh/20140612/691055) , Jifflenow ...
Breaking Biology News(10 mins):New telemetry implants expected to change how large animal toxicology studies are conducted 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 3Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 4Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 2Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 3
... by University of Toronto Scarborough researchers gives the best ... severe mental illness called Borderline Personality Disorder (BPD), and ... work shows that brain regions that process negative emotions ... with BPD, while brain regions that would normally help ...
... since the early 1960s have fueled a sharp increase in ... consumed by the average person over the course of a ... McGill University. Between 1961 and 2007, rising meat consumption ... world,s per capita "phosphorus footprint," the researchers conclude in a ...
... organisms. They are still present today in oceans and ... and evolving into multicellular forms, they played a key ... This has, now, been demonstrated by a team of ... from the University of Zurich. According to their studies, ...
Cached Biology News:New insights into the 'borderline personality' brain 2Dietary shifts driving up phosphorus use 2Pediatric coding top tips and pediatric CPT changes 2013 2
(Date:12/24/2014)... , Dec. 24, 2014  United Therapeutics Corporation ... Medtronic, Inc. (NYSE: MDT ) has ... Food and Drug Administration (FDA) for the use ... infusion system (including a newly developed catheter) for ... Injection delivered intravenously to patients with pulmonary arterial ...
(Date:12/24/2014)... 23, 2014 GMO corn cases filed ... Syngenta, are in the process of being consolidated in ... case is In Re: Syngenta AG MIR 162 Corn ... for the District of Kansas. , Management of the ... over to U.S. District Judge John W. Lungstrum.* , ...
(Date:12/24/2014)... Dallas, Texas (PRWEB) December 23, 2014 ... on methyl mercaptan such as its definition, ... also presents product specification, manufacturing process, and ... regions, technology and applications. The analysis also ... survey, marketing channels, industry development trend and ...
(Date:12/24/2014)... Dec. 23, 2014 Vermillion, Inc. (Nasdaq: ... gynecologic disease, announced today that investors including Oracle ... Fund LLC and several Vermillion directors have agreed ... of Vermillion,s common stock and warrants to purchase ... private placement.  Under the terms ...
Breaking Biology Technology:United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 3United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 4Carey Danis & Lowe Reports on Syngenta GMO Corn Transfer Order 2Worldwide Methyl Mercaptan Market 2015-2020 Forecasts on Development & Trends Now Available at ReportsnReports.com 2Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 2Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 3Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 4Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 5
... over 60% of evaluable patients -, SEOUL, South ... today reported interim data from an ongoing phase 2 ... cell,lung cancer (NSCLC). This open-label phase 2 trial is ... NSCLC who have adenocarcinoma,histology and meet one of the ...
... Computing researchers at Houston,s Rice University and ... today announced the formation of a $2.6-million Institute ... valued at 4 million Singapore dollars, aims to ... microchips -- special-purpose computer chips that power everything ...
... Beckman Coulter,Inc. (NYSE: BEC ), a ... automate, and innovate complex biomedical testing,announced today that ... will present at the 2007 Bear Stearns Healthcare,Conference ... (EDT). (Logo: http://www.newscom.com/cgi-bin/prnh/20031202/BECLOGO ) The ...
Cached Biology Technology:Exelixis Reports Encouraging Interim Data From a Phase 2 Trial of XL647 as First-Line Therapy for Non-Small Cell Lung Cancer 2Exelixis Reports Encouraging Interim Data From a Phase 2 Trial of XL647 as First-Line Therapy for Non-Small Cell Lung Cancer 3Exelixis Reports Encouraging Interim Data From a Phase 2 Trial of XL647 as First-Line Therapy for Non-Small Cell Lung Cancer 4Rice, Nanyang Tech collaborate on sustainable nanoelectronics 2Rice, Nanyang Tech collaborate on sustainable nanoelectronics 3Beckman Coulter to Present at the Bear Stearns Healthcare Conference 2
Request Info...
Request Info...
CoverWell imaging chamber gasket with adhesive, one chamber, 20 mm diameter, 1.0 mm deep *set of 40* Cell Biology Imaging Tools and Accessories Microscope Slide Accessories...
Request Info...
Biology Products: