Navigation Links
Bacteria that cause tooth decay able to survive without important biochemical pathway

Leave it to the bacteria that cause tooth decay to be able to live without something all cells were thought to require.

Scientists have long believed a certain biochemical pathway involved in the folding and delivery of proteins to cell membranes is essential for survival. Now University of Florida researchers have discovered that Streptococcus mutans, the decay-causing organism that thrives in many a mouth, can do just fine without it.

The findings, reported this month in the Proceedings of the National Academy of Sciences, have rocked the cellular biology scientific community, which has long considered the pathway to be crucial. The report may also explain why strains of the bacteria can survive in the harsh acidic environment they create in the mouth.

"We were met with skepticism ?because the dogma was that this biochemical pathway is key for all living cells," said study investigator Jeannine Brady, Ph.D., an associate professor of oral biology at the UF College of Dentistry. "As far as we know, this is the first example of any bacteria that can cope without this pathway; all of the existing literature indicated it is vital."

The signal recognition particle, or SRP, pathway is a primary mechanism by which proteins are chaperoned from cellular assembly lines, where they are made, to the protective outer surface of the cells, where they are inserted. Without a steady infusion of proteins, the membrane weakens and the cell - in this case, a bacterium - becomes unable to protect itself from harsh environmental conditions.

In the human mouth, its natural environment, it is typically S. mutans that goes on the attack. When sugary foods are eaten, the S. mutans population explodes, excreting lactic acid as it digests sugar. The acid makes life difficult for other helpful bacteria and demineralizes tooth enamel, causing decay.

According to the U.S. Centers for Disease Control and Prevention, 95 percent of adult Americans
'"/>

Source:University of Florida


Page: 1 2 3

Related biology news :

1. Bacteria collection sheds light on urinary tract infections
2. Solution to Pollution: New Bacteria Eats Toxic Waste
3. The Bacterias guide to survival
4. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
5. Bacterial genome sheds light on synthesizing cancer-fighting compounds
6. Where Bacteria Get Their Genes
7. Bacteria feed on smelly breath (and feet)
8. New insight into autoimmune disease: Bacterial infections promote recognition of self-glycolipids
9. Bacteria use hosts immune response to their competitive advantage
10. Say what? Bacterial conversation stoppers
11. Bacteria are key to green plastics, drugs
Post Your Comments:
(Date:12/10/2014)... NEW YORK , Dec. 8, 2014 You,ve ... online banking account but can,t remember your password, site key ... birthday? Who was your first grade teacher? ... launches the app that will finally put an ... PINs – 1U TM . 1U leverages a ...
(Date:12/10/2014)... Forest Baptist Medical Center today announced plans for a ... Funding for this $50 million capital project is part ... launched next summer. The medical education ... R.J. Reynolds Tobacco Company complex, adjacent to 525@vine in ... plans to be ready to welcome medical students in ...
(Date:12/10/2014)... , Dec. 08, 2014 Research and Markets ... addition of the "Biometrics Market in Japan ... http://photos.prnewswire.com/prnh/20130307/600769 The ... such as rural banking and upgradation of the ... witnessed in the market. Besides the aforementioned projects, ...
Breaking Biology News(10 mins):The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 3Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 3Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 4Biometrics Market in Japan 2014-2018: Key Vendors are DDS, Fujitsu, Hitachi and NEC 2
... a unique vulnerability that can be exploited to make ... Washington University School of Medicine in St. Louis report. ... that tumors have a built-in mechanism that protects them ... benefit of hyperthermia and radiation as a combined therapy. ...
... way to rejuvenate dead nerve endings and a device ... among this years nine winners at NJITs annual provosts ... I walk through this showcase is the sophisticated array ... undergraduate students, said NJIT Provost Priscilla P. Nelson. ...
... the US, many people believe that the recent proliferation of ... people aim to significantly reduce the amount of saturated fats ... healthier, and happier. However, many leading researchers in the medical ... In FAT: ITS NOT WHAT YOU THINK (Prometheus, $15.95), technical ...
Cached Biology News:Researchers find way to make tumor cells easier to destroy 2NJIT applauds students for studies on brain injury, glaucoma and more 2Fat: Its not what you think! 2
(Date:12/24/2014)... and NEW YORK , ... from its open-label pilot study of mazindol in children ... Development and Therapy in December 2014 . ... mazindol in children with attention deficit/hyperactivity disorder" ( Konofal ... 2014 Dec 1;8:2321-2332. eCollection 2014 ) shows ...
(Date:12/22/2014)... 2014  Alternative Energy & Environmental Solutions, Inc., ... a letter of intent to acquire BioTechPharma Corporation, ... a nanotechnology-based development platform used to create drug ... on-site collection and testing to identify infectious disease, ... an immediate, non-invasive and cost-effective manner. ...
(Date:12/22/2014)... 2014 ITRA Global, one of the ... commercial real estate, has further expanded its global reach ... and Brisbane, Western Australia, reports Mylinda Vick, CCIM, Chairman ... ITRA Global / ACORPP (Australian Corporate Property and Projects) ... providing property services to a wide range of clients ...
(Date:12/19/2014)... BioPlus Specialty Pharmacy (BioPlus), one of the nation’s ... Pharm.D. to the newly created position of Vice President ... Dr. Maroulis will continue to manage the entire specialty ... pharmacies as the company expands. Dr. Maroulis has been ... has served in many different capacities in the pharmacy, ...
Breaking Biology Technology:Redefining ADHD: A New Approach & A Shift of Paradigm in ADHD Therapeutics 2Redefining ADHD: A New Approach & A Shift of Paradigm in ADHD Therapeutics 3ALNE Announces Intention To Acquire BioTechPharma 2ITRA Global Continues International Expansion in Perth and Brisbane, Australia 2BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2
... 19 The 2009 Frost & Sullivan European ... Xenometrix AG in recognition of its active role ... cytotoxicity assays. (Logo: http://www.newscom.com/cgi-bin/prnh/20081117/FSLOGO )These test ... drug discovery, improve the effectiveness of drug discovery ...
... sail to Baltic, Black and Mediterranean Seas, sampling ... local San Diego supporters Beyster Family Foundation Fund ... DIEGO, March 18, The J. Craig Venter ... new Sorcerer II Expedition--the J. Robert Beyster and ...
... Pharmatech Oncology has been selected by the Fitzsimons ... Colorado Science + Technology Park at Fitzsimons. The ... companies. The majority of the companies are in ... expanding their research on commercial products. Pharmatech Oncology ...
Cached Biology Technology:Frost & Sullivan European Drug Discovery Product Innovation Award Bestowed on Xenometrix AG 2Frost & Sullivan European Drug Discovery Product Innovation Award Bestowed on Xenometrix AG 3Venter Institute Launches the J. Robert Beyster and Life Technologies 2009-2010 Research Voyage of the Sorcerer II Expedition 2Venter Institute Launches the J. Robert Beyster and Life Technologies 2009-2010 Research Voyage of the Sorcerer II Expedition 3Venter Institute Launches the J. Robert Beyster and Life Technologies 2009-2010 Research Voyage of the Sorcerer II Expedition 4Venter Institute Launches the J. Robert Beyster and Life Technologies 2009-2010 Research Voyage of the Sorcerer II Expedition 5The Fitzsimons Redevelopment Authority Selects Pharmatech Oncology as Preferred Vendor 2
... 384 Round Well ... Thermo Labsystems wide range ... ideal for high-throughput screening ... miniaturization of assays and ...
HLA-DRbeta (DA2)...
...
Bovine Renal Artery Endothelial Cells (BRAEC) (>500,000 cells)...
Biology Products: