Navigation Links
Bacteria research offers hope for new vaccine against meningococci

Each year 170,000 people around the world die of this type of meningitis, according to the World Health Organization, WHO. Bacterial meningitis, as the disease is called, can even spark epidemics: in Africa 250,000 people were affected in a matter of weeks in the late 1990s. Without treatment, mortality among those who contract the disease is 85-90 percent, with treatment some 10-15 percent. Patients also run a high risk of serious disability after recovery.

Only humans are susceptible to infection from meningococci. In its modeling system Ann-Beth Jonsson’s research team therefore used mice that produce the human receptor that the bacteria bind to. Marking the bacteria to emit light, the scientists used cameras to monitor their activities in the living mice during the course of the disease.

“The bacteria are almost knocked out by the immune defense system, but then they resurge, this time with alterations in the surface protein. What’s more, we discovered that the bacteria aggregate in the thyroid and can impact hormone production during the infection,?says Ann-Beth Jonsson.

The study also shows that bacteria that lack a certain adhesin (the protein that the bacteria cells use to adhere to the receptors) could not attach to mucous linings.

Thanks to the new system the research team has developed, it is now possible to rapidly and effectively monitor the function of various vaccine candidates and new drugs, obviating the numerous costly and time-consuming tests that have been necessary until now. At the same time, the system provides a clear picture of the process of infection.

“With these findings as tools, we can continue to study the course of the disease and test vaccines on living organisms. Moreover we will be able to find new strategies for improving the prognoses for those who are affected by meningococcus disorders,?says Ann-Beth Jonsson.
'"/>

Source:Public Library of Science


Page: 1

Related biology news :

1. Bacteria collection sheds light on urinary tract infections
2. Solution to Pollution: New Bacteria Eats Toxic Waste
3. The Bacterias guide to survival
4. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
5. Bacterial genome sheds light on synthesizing cancer-fighting compounds
6. Where Bacteria Get Their Genes
7. Bacteria feed on smelly breath (and feet)
8. New insight into autoimmune disease: Bacterial infections promote recognition of self-glycolipids
9. Bacteria use hosts immune response to their competitive advantage
10. Say what? Bacterial conversation stoppers
11. Bacteria are key to green plastics, drugs
Post Your Comments:
(Date:4/17/2014)... new early-warning signs of the potential loss of sight ... for the diagnosis and treatment of diabetic retinopathy, potentially ... "We had not expected to see such striking changes ... Elsner, professor and associate dean in the IU School ... set out to study the early signs, in volunteer ...
(Date:4/17/2014)... wild animals and plant life, but there,s an invisible ... in the soil, decomposing organic matter and releasing carbon ... fungi play in ecological systems, their identities have only ... generated a genetic map of more than 10,000 species ... this week in the Proceedings of the National ...
(Date:4/17/2014)... View of Domestication," a special feature of The ... ( PNAS ) published April 29, raises a ... deep history that most of us take for granted. ... in many spots around the globe shifted from hunting ... and plants. , It seems so straightforward and yet ...
Breaking Biology News(10 mins):New technique detects microscopic diabetes-related eye damage 2New technique detects microscopic diabetes-related eye damage 3Stanford biologists help solve fungal mysteries 2Stanford biologists help solve fungal mysteries 3Genetic study tackles mystery of slow plant domestications 2Genetic study tackles mystery of slow plant domestications 3Genetic study tackles mystery of slow plant domestications 4
... August 8th, 2011, Shenzhen, China BGI, the ... Shenzhen Second People,s Hospital, announced today that the study ... cell carcinoma (TCC) of the bladder was published online ... valuable genetic basis for future studies on TCC, suggesting ...
... WEST LAFAYETTE, Ind. -- A Purdue University scientist is urging ... allowed for U.S. consumption and arguing that not doing so ... William Muir, a professor of animal sciences, said that based ... Administration, AquAdvantage (AA) salmon poses little real risk to the ...
... is currently used as a component of intravenous nutrition and ... protection for patients suffering from heart attacks. Current ... of the ischemic period, when blood flow to tissues is ... blood flow. It is well known that injury to the ...
Cached Biology News:Research discovers frequent mutations of chromatin remodeling genes in TCC of the bladder 2Scientist urges government ruling on genetically engineered salmon 2Scientist urges government ruling on genetically engineered salmon 3
(Date:1/15/2014)... (PRWEB) January 15, 2014 More than ... and about 1 in 3 seniors will die with ... ). These jaw-dropping figures have shocked many Americans into ... hopefully, help prevent these tragic age-related cognitive disorders. Jonathan ...
(Date:1/15/2014)... Sunnyvale, CA (PRWEB) January 15, 2014 ... throughput research solutions, today announced that Lupin Limited, one ... of Freeslate’s CM Protégé PharmD System for ... in Mumbai, India, is focused on a wide range ...
(Date:1/14/2014)... Histogen, Inc., a regenerative medicine company developing ... simulated embryonic conditions, today announced that they have entered ... for physician-dispensed aesthetic products containing Histogen’s proprietary multipotent cell ... an amendment to the existing license between Histogen and ...
(Date:1/14/2014)... BETHESDA, Md. , Jan. 14, 2014  Organovo ... institutes from the National Institutes of Health (NIH) to ... more effective treatments to patients on a faster timeline. ... Translational Sciences (NCATS) and the National Eye Institute (NEI) ...
Breaking Biology Technology:Biohack Pure Offers 5 Tips for Increasing Memory in 2014 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 2Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 3Organovo Announces Collaboration with National Institutes of Health 2Organovo Announces Collaboration with National Institutes of Health 3
... 26 Bionovo, Inc.,(Nasdaq: BNVI ) (the "Company") today ... of common stock at a price to the public of,$2.50 ... stock,at $3.50 per share at a price of $0.10 per ... to purchase up to an additional 15% of,the offering to ...
... - International Call for Patient Group Task ... international research, including the views of bodies that,represent ... today in,Dublin, Ireland - one of the world,s ... campaigner has called for patient,groups across Europe to ...
... Sunesis,Pharmaceuticals, Inc. (Nasdaq: SNSS ), a ... that,management will hold an investor conference call on ... PT to discuss financial results for the,third quarter ... the call via (888),297-0358 (U.S. and Canada) or ...
Cached Biology Technology:Bionovo Announces the Pricing of Public Offering of Shares of Common Stock 2Bionovo Announces the Pricing of Public Offering of Shares of Common Stock 3Patients Fail to Take Fake Medicines Risk Seriously 2Patients Fail to Take Fake Medicines Risk Seriously 3
... Technology's family of light scattering instruments. The ... chromatograph and enables you to get multi-angle ... HTmD is easily installed in the oven ... 2000 device and enables you to get ...
...
... Experion HighSens reagents and supplies, for ... supplies sufficient to perform high-sensitivity RNA ... on the Experion automated electrophoresis system. ... 20 microliters RNA HighSens stain, 20 ...
MAb to Verotoxin II (SLT-2a) Verotoxin II (Shiga-like) A subunit (SLT-2a)...
Biology Products: