Navigation Links
Bacteria recognize antimicrobials, respond with counter-defenses

Many living things, from fruit flies to people, naturally produce disease-fighting chemicals, called antimicrobial peptides, to kill harmful bacteria. In a counter move, some disease-causing bacteria have evolved antimicrobial detectors. The bacteria sense the presence of antimicrobial peptides as a warning signal. This alarm sets off a reaction inside the bacteria to avoid destruction.

University of Washington (UW) and McGill University researchers have revealed a molecular mechanism whereby bacteria can recognize tiny antimicrobial peptide molecules, then respond by becoming more virulent. Their studies were done on the bacterium Salmonella typhimurium. The findings were published in the Aug. 12 edition of Cell.

Salmonella typhimurium can contaminate meats such as beef, pork, chicken, as well as cereals and other foods, and cause severe intestinal illness. Certain strains of the bacteria are difficult to treat, and are behind the increase of salmonellosis in people. Some food science institutes anticipate that virulent strains of salmonella will become more common throughout the food chain. Learning how this sometimes deadly organism fights back against the immune system may lead to treatments that get around bacterial resistance.

Work in this area may also suggest ways other disease-causing, Gram-negative bacteria maintain a stronghold in the midst of the body's attempts to get rid of them.

Strangely enough, the same molecules that the body sends out to help destroy salmonella inadvertently launch bacterial defenses. It is as if missiles armed, rather than demolished, the target. The body's antimicrobial peptides bind to an enzyme, PhoQ, that acts as a watchtower and interceptor near the surface of bacteria cell membranes. The peptide binding activates PhoQ, which sets off a cascade of signals. The signals turn on a large set of bacterial genes. Some of genes are responsible for products that fortify the bacterial cell surface and
'"/>

Source:University of Washington


Page: 1 2

Related biology news :

1. Bacteria collection sheds light on urinary tract infections
2. Solution to Pollution: New Bacteria Eats Toxic Waste
3. The Bacterias guide to survival
4. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
5. Bacterial genome sheds light on synthesizing cancer-fighting compounds
6. Where Bacteria Get Their Genes
7. Bacteria feed on smelly breath (and feet)
8. New insight into autoimmune disease: Bacterial infections promote recognition of self-glycolipids
9. Bacteria use hosts immune response to their competitive advantage
10. Say what? Bacterial conversation stoppers
11. Bacteria are key to green plastics, drugs
Post Your Comments:
(Date:7/9/2014)... with traumatic injuries have identified an immune marker ... a hospital-acquired infection. The study, led by clinician-scientists ... June in the journal Shock , is ... to the clinical implementation of quick-turnaround immune function ... system damage following critical illness or injury in ...
(Date:7/9/2014)... shark species may be able to cope with the rising ... , The Arctic today is best known for its tundra ... Roughly 53 to 38 million years ago during what is ... to a huge temperate forest with brackish water, home to ... creatures, crocodiles and giant tortoises. Much of what is known ...
(Date:7/9/2014)... U.S. may be on the verge of an economy driven ... cleaner than coal and is undergoing a production boom. It ... but recent research is casting serious doubts over just how ... & Engineering News (C&EN), the weekly news magazine of ... a senior correspondent at C&EN, explains that when burned as ...
Breaking Biology News(10 mins):Immune function predicts infection risk among child trauma patients 2Immune function predicts infection risk among child trauma patients 3Shark teeth analysis provides detailed new look at Arctic climate change 2Shark teeth analysis provides detailed new look at Arctic climate change 3
... SLOVENIARidge and furrow rainwater-harvesting (RFRH) systems with mulches were ... northwest China to improve water availability and to increase ... rainwater harvesting zones, and bare or mulched furrows serve ... and are being promoted in many parts of the ...
... that can cope with sudden fluctuations in the weather could ... of plants. Scientists studying how tiny algae renew ... useful in developing crops suited to climates in which weather ... protein renewal takes place dictates how quickly they can adapt ...
... A manmade package filled with nature,s bone-building ingredients delivers ... bone injuries faster than products currently available, Cleveland researchers ... surgical elastic "implant device," essentially a wrapping that mimics ... growth factors and other natural components of the periosteum ...
Cached Biology News:Improved rainwater harvesting system promising 2It's all in the wrapping 2
(Date:1/15/2014)... Reston, VA (PRWEB) January 15, 2014 ... education have continued their sponsorship of an annual competition ... interest in, and access to, innovative STEM study. The ... , TEAMS: Tests of Engineering Aptitude, Mathematics, and ...
(Date:1/15/2014)... Toronto, ON (PRWEB) January 15, 2014 ... an experimental new therapy for the treatment of tinnitus. ... unique tinnitus frequency, and over a period of weeks to ... Notched Sound Therapy in two forms: Notched Music and Notched ...
(Date:1/14/2014)... Communications, a leading provider of strategic communications services to corporations and ... the United States and Europe ... JD, is returning to the firm,s Washington, D.C. ... more than two years of service as Associate Commissioner for the ...
(Date:1/14/2014)... iLab Solutions, the leader in core facility ... of Product Strategy. In this role, Michelle will work with ... guide in the development of iLab products. Her main goal ... benefit to the scientific community by offering the most advanced, ...
Breaking Biology Technology:Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 2Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 4Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 5Former FDA Associate Commissioner Returns To 3D Communications 2iLab Solutions Announces Michelle Detwiler as the New Director of Product Strategy 2
... - Tamiflu Remains Fully Effective ... Latest surveillance data coming through ... virologists and clinicians indicates that,the influenza A(H3N2) virus is ... on the data published by ECDC Roche confirms that ...
... Conn., Jan. 19 SurgiQuest, Inc. is pleased to ... agreement with Intuitive Surgical, Inc. (Nasdaq: ISRG ... system using AirSeal(TM) technology for use with Intuitive,s laparoscopic ... invasive surgical procedures because it allows the surgeon to ...
... Corporation,s (Amex: ETC ) ("ETC" or ... of two BARA-MED(R) XD Monoplace Hyperbaric Chambers for ... St. Luke,s Hospital - Allentown Campus is part ... a nationally recognized, regional, integrated network of non-profit ...
Cached Biology Technology:Seasonal Influenza Activity Increasing Across Europe - H3N2 Dominant Strain 2Seasonal Influenza Activity Increasing Across Europe - H3N2 Dominant Strain 3Seasonal Influenza Activity Increasing Across Europe - H3N2 Dominant Strain 4SurgiQuest Signs a Development and Supply Agreement with Intuitive Surgical for MIS Access Utilizing the AirSeal(TM) Technology 2Environmental Tectonics Corporation Announces the Sale of Two BARA-MED(R) XD Monoplace Hyperbaric Chambers 2Environmental Tectonics Corporation Announces the Sale of Two BARA-MED(R) XD Monoplace Hyperbaric Chambers 3Environmental Tectonics Corporation Announces the Sale of Two BARA-MED(R) XD Monoplace Hyperbaric Chambers 4
Goat polyclonal to Rabenosyn 5 ( Abpromise for all tested applications). Antigen: Synthetic peptide: ELKHTLAKQKGGTD, corresponding to C terminal amino acids 771-784 of Human Rabenosyn 5. Entr...
Acetyl CoA Carboxylase Antibody...
Anti-Human IFN-Gamma Receptor Chain 2 (beta chain) [CD119], Rabbit serum, NON-neutralizing polyclonal antibody...
AANAT [Arylalkylamine N-acetyltransferase; EC 2.3.1.87]...
Biology Products: